Mechanochemical destruction of fluoxetine in the presence of ammonium persulfate and magnesium oxide
Journal of Behdasht dar Arseh (i.e., Health in the Field),
Vol. 13 No. 2 (1404),
4 January 2026,
Page 1-13
https://doi.org/10.22037/jhf.v13i2.46145
Background and Aims: Fluoxetine is widely used as a pharmaceutical agent, and its residues, whether present as solid waste or dissolved in wastewater, pose a significant environmental concern due to its distinct chemical structure. While most studies have focused on the removal of pharmaceuticals in their dissolved form, this study investigates the effectiveness of a combined mechanochemical process integrated with an advanced oxidation to degrade fluoxetine in its solid state.
Materials and Methods: Powdered fluoxetine was subjected to planetary ball milling in the presence of magnesium oxide and ammonium persulfate under various experimental conditions, including reaction time, rotational speed, ball-to-material ratio, and mass ratios of the reactants. The extent of fluoxetine degradation and mineralization was subsequently quantified. All procedures adhered strictly to relevant ethical guidelines.
Results: The results demonstrated that the enhanced mechanochemical process achieved near-complete (99.66%) degradation of fluoxetine. Under optimized conditions, mineralization reached 80.85%. The simultaneous use of magnesium oxide and ammonium persulfate significantly improved the process efficiency, exhibiting a pronounced synergistic effect in both the degradation and mineralization of fluoxetine.
Conclusion: The surface characteristics of magnesium oxide and its ability to generate reactive sulfate radicals contributed substantially to the enhanced degradation of the drug. Therefore, the integrated mechanochemical and advanced oxidation process can be considered an innovative and effective approach for the safe treatment of solid pharmaceutical waste.