Introduction: Clinical trials have long been vital to advancing how to prevent, diagnose, and treat diseases. However, traditional clinical trials can be difficult and slow. With application to precision medicine, new concepts in clinical trial design increase the speed and flexibility of clinical trials, increasing the likelihood that a trial will benefit the most people who participate.
Methods: In today's world, with the change in lifestyle, we are facing the spread of various diseases. and doctors make many treatment decisions in different stages of the disease. In practice, these multiple treatment decisions are how doctors treat, but statistically, this is a dynamic treatment regimen (DTR ). Effective DTRs can be developed and studied in clinical trials called sequential multiple Assignment randomized trials (SMART).
Results: A total of 29 studies were extracted from reliable databases and websites, and we reviewed research related to SMART.
Discussion: In this research, we first introduced SMART and then compared SMART and several RCT plans. By doing these comparisons, we showed more the unique features of SMART in the family of RCT designs and we also examined the researches related to the topic of SMART.
Conclusion: Considering that most experiments are done in one step and ignore the intermediate events and focus on the final event. Introducing SMART plans and the concept of DTRs is important for researchers and clinical colleagues, as treatment guidelines must encompass entire treatment regimens to be useful to clinicians and patients.