Anti-inflammatory Activities of Nannorrhops ritchieana (Griff.) Aitch Inflorescence Extract in an Animal Model
Archives of Advances in Biosciences,
Vol. 14 No. 1 (2023),
19 February 2023
,
Page 1-9
https://doi.org/10.22037/aab.v14i1.41620
Abstract
Materials and Methods: The carrageenan-induced paw edema method was used to evaluate the acute anti-inflammatory effects of the NRE extract (50,100, and 200mg/kg, i.p.). The postive and negative control groups received mefenamic acid and normal saline, respectively. Then, the rats’ paw tissues were removed and collected for studying tumor necrosis factor (TNF-α) level. In addition, the cotton pellet-induced granuloma method was utilized to assess the chronic anti-inflammatory effects of the extract (100 and 200 mg/kg daily for 8 days, i.p.). The postive and negative control groups received indomethacin and saline, respectively. On the last day of the cotton pellet test, the rat’s serum was collected for interleukin-1 beta (IL-1β) determination.
Results: In the carrageenan test, the extract significantly reduced the paw edema compared to that of the control (p<0.05). The anti-inflammatory activity (100 and 200 mg/kg) of the extract was similar to that of the mefenamic acid group (P<0.05). TNF-α levels demonstrated significant anti-inflammatory effects just at the dose of 200 mg/kg. In granuloma induced by cotton pellets, NRE was also effective based on the granuloma formation and the transudate amount. The anti-inflammatory activity of the inflorescence extract was found to be the same as the indomethacin group, whereas IL-1β did not represent significant changes.
- Inflorescence
- Nannorrhops ritchieana
- Rat
- Anti inflammatory
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References
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