Evaluation of Response Inhibition in the Face of Cognitive and Emotional Stimuli in Patients with Frontal Lobe Tumors before and after Surgery
Archives of Advances in Biosciences,
Vol. 14 No. 1 (2023),
19 February 2023
,
Page 1-11
https://doi.org/10.22037/aab.v14i1.40381
Abstract
Introduction: The functions of specialized brain parts undoubtedly influence emotional inhibition. Numerous studies have considered the prefrontal cortex of the brain’s two hemispheres to be responsible for this behavior. However, few studies have addressed the question of to what degree a change in this brain unit can affect response inhibition and reaction time in the face of emotional stimuli. Therefore, the current study aimed to investigate emotional behavior in patients with frontal lobe gliomas.
Materials and Methods: In this quasi-experimental research, the Integrated Visual and Auditory (IVA) test and affective Go/No-Go task in the areas of happiness and anger, focusing on response accuracy and reaction time were performed for 16 patients with frontal lobe lesions and 20 healthy individuals. These tests were repeated three months after surgery. The t-test, Wilcoxon signed rank test, Mann-Whitney, and their related equivalence test were applied for statistical analysis.
Results: The results revealed that following surgery, there was an improvement in the patients’ reaction times and response accuracy to both emotional stimuli especially against the stimulus of anger exist. The IVA results showed the significant improvement in neurocognitive condition of all patients following surgery.
Conclusion: Toward improving the emotional conditions, lesion resection surgery could significantly help these patients regain their normal cognitive function. However, a difference was seen between patients and healthy individuals.
- Emotion
- Emotion inhibition
- Frontal
- Glioma
- Neurosurgery
How to Cite
References
Domínguez Duque JF, Turner R, Lewis ED, Egan G. Neuroanthropology: A humanistic science for the study of the culture–brain nexus. Soc Cogn Affect Neurosci. 2010; 5(2-3):138-47. [DOI:10.1093/scan/nsp024] [PMID] [PMCID]
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, et al. Glioma. Nat Rev Dis Primers. 2015; 1(1):1-18. [DOI:10.1038/nrdp.2015.17] [PMID]
Johnston BR, Colson E, Falk D, St John G, Bodley JH, McCay BJ, et al. On happiness. Am Anthropol. 2012; 114(1):6-18. [DOI:10.1111/j.1548-1433.2011.01393]
Tăbăcaru B-A. Evaluation of emotional influence on EEG activity in the frontal lobes. 2013 E-Health and Bioengineering Conference (EHB); 2013. [DOI:10.1109/EHB.2013.6707291]
Carl JR, Soskin DP, Kerns C, Barlow DH. Positive emotion regulation in emotional disorders: A theoretical review. Clin Psychol Rev. 2013; 33(3):343-60. [DOI:10.1016/j.cpr.2013.01.003] [PMID]
Oatley K, Johnson-Laird PN. Basic emotions in social relationships, reasoning, and psychological illnesses. Emot Rev. 2011; 3(4):424-33. [DOI:10.1177/1754073911410738]
Juszkiewicz A, Lachowicz-Tabaczek K, Wróbel M. Self-esteem, gender, and emotional contagion: What predicts people’s proneness to “catch” the feelings of others? Pers Individ Differ. 2020; 157:109803. [DOI:10.1016/j.paid.2019.109803]
Lang PJ, Bradley MM. Emotion and the
motivational brain. Biol Psychol. 2010; 84(3):437-50. [DOI:10.1016/j.biopsycho.2009.10.007] [PMID] [PMCID]
Macmillan M, Lena ML. Rehabilitating Phineas
Gage. Neuropsychol Rehabil. 2010; 20(5):641-58. [DOI:10.1080/09602011003760527] [PMID]
Stuss DT. Traumatic brain injury: relation to executive dysfunction and the frontal lobes. Curr Opin Neurol. 2011; 24(6):584-9. [DOI:10.1097/WCO.0b013e32834c7eb9] [PMID]
Brown BK, Murrell J, Karne H, Anand A. The effects of DAT1 genotype on fMRI activation in an emotional go/no-go task. Brain Imaging Behav. 2017; 11(1):185-93. [DOI:10.1007/s11682-016-9516-7] [PMID] [PMCID]
Shin YB, Kim H, Kim SJ, Kim JJ. A neural mechanism of the relationship between impulsivity and
emotion dysregulation in patients with Internet gaming disorder. Addict Biol. 2021; 26(3):e12916. [DOI:10.1111/adb.12916] [PMID]
Egashira K, Matsuo K, Nakashima M, Watanuki T, Harada K, Nakano M, et al. Blunted brain activation in patients with schizophrenia in response to emotional cognitive inhibition: a functional near-infrared spectroscopy study. Schizophr Res. 2015; 162(1-3):196-204. [DOI:10.1016/j.schres.2014.12.038] [PMID]
Fishburn FA, Hlutkowsky CO, Bemis LM, Huppert TJ, Wakschlag LS, Perlman SB. Irritability uniquely predicts prefrontal cortex activation during preschool
inhibitory control among all temperament domains: A LASSO approach. Neuroimage. 2019; 184:68-77. [DOI:10.1016/j.neuroimage.2018.09.023]
Arbula S, Pacella V, De Pellegrin S, Rossetto M, Denaro L, D’Avella D, et al. Addressing the selective role of distinct prefrontal areas in response suppression: A study with brain tumor patients. Neuropsychologia. 2017; 100:120-30. [DOI:10.1016/j.neuropsychologia.2017.04.018] [PMID] [PMCID]
Corell A, Carstam L, Smits A, Henriksson R, Jakola A. Age and surgical outcome of low‐grade glioma in Sweden. Acta Neurol Scand. 2018; 138(4):359-68. [DOI:10.1111/ane.12973] [PMID]
Tinius TP. The integrated visual and auditory continuous performance test as a neuropsychological measure. Arch Clin Neuropsychol. 2003; 18(5):439-54. [DOI:10.1093/arclin/18.5.439] [PMID]
Moreno-García I, Delgado-Pardo G, Roldán-Blasco C. Attention and response control in ADHD. Evaluation through integrated visual and auditory continuous performance test. Span J Psychol. 2015; 18:E1. [DOI:10.1017/sjp.2015.2] [PMID]
Gutiérrez-Cobo MJ, Cabello R, Fernández-Berrocal P. The three models of emotional intelligence and performance in a hot and cool go/no-go task in undergraduate students. Front Behav Neurosci. 2017; 11:33. [DOI:10.3389/fnbeh.2017.00033] [PMID] [PMCID]
Iria C, Barbosa F, Paixão R. The identification of negative emotions through a go/no-go task: Comparative research in criminal and non-criminal psychopaths. Eur Psychol. 2012; 17(4):291. [DOI:10.1027/1016-9040/a000101]
Walker E, Nowacki AS. Understanding equivalence and noninferiority testing. J Gen Intern Med. 2011; 26:192-6. [DOI:10.1007/s11606-010-1513-8]
Bauer P, Kieser M. A unifying approach for
confidence intervals and testing of equivalence
and difference. Biometrika. 1996; 83(4):934-7. [DOI:10.1093/biomet/83.4.934]
Arble E, Kuentzel J, Barnett D. Convergent validity of the Integrated Visual and Auditory Continuous Performance Test (IVA+ Plus): Associations with working memory, processing speed, and behavioral ratings. Arch Clin Neuropsychol. 2014; 29(3):300-12. [DOI:10.1093/arclin/acu006] [PMID]
Valk JMd, Wijnen JG, Kret ME. Anger fosters action. Fast responses in a motor task involving approach movements toward angry faces and bodies. Front Psychol. 2015; 6:1240. [DOI:10.3389/fpsyg.2015.01240] [PMID] [PMCID]
Mu YG, Huang LJ, Li SY, Ke C, Chen Y, Jin Y, et al. Working memory and the identification of facial expression in patients with left frontal glioma. Neuro Oncol. 2012; 14(4):81-9. [DOI:10.1093/neuonc/nos215] [PMID]
Fang S, Wang Y, Jiang T. The influence of frontal lobe tumors and surgical treatment on advanced cognitive functions. World Neurosurg. 2016; 91:340-6. [DOI:10.1016/j.wneu.2016.04.006] [PMID]
Jenkins RB, Xiao Y, Sicotte H, Decker PA, Kollmeyer TM, Hansen HM, et al. A low-frequency variant at 8q24. 21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation. Nat Genet. 2012; 44(10):1122-5. [DOI:10.1038/ng.2388] [PMID]
Santini B, Talacchi A, Squintani G, Casagrande F, Capasso R, Miceli G. Cognitive outcome after awake surgery for tumors in language areas. J Neurooncol. 2012; 108(2):319-26. [DOI:10.1007/s11060-012-0817-4] [PMID]
Campanella F, Shallice T, Ius T, Fabbro F, Skrap M. Impact of brain tumour location on emotion and personality: a voxel-based lesion–symptom mapping study on mentalization processes. Brain. 2014; 137(9):2532-45. [DOI:10.1093/brain/awu183] [PMID]
Llamas-Alonso LA, Barrios FA, González-Garrido AA, Ramos-Loyo J. Emotional faces interfere with
saccadic inhibition and attention re-orientation: An fMRI study. Neuropsychologia. 2022; 173:108300. [DOI:10.1016/j.neuropsychologia.2022.108300] [PMID]
Siep N, Tonnaer F, van de Ven V, Arntz A, Raine A, Cima M. Anger provocation increases limbic and decreases medial prefrontal cortex connectivity with the left amygdala in reactive aggressive violent offenders. Brain Imaging Behav. 2019; 13(5):1311-23. [DOI:10.1007/s11682-018-9945-6] [PMID] [PMCID]
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