Relationship between β-globin gene mutations and blood factors in Beta- Thalassemia carriers
Journal of Behdasht dar Arseh (i.e., Health in the Field),
Vol. 3 No. 2,
21 June 2015
,
Page 1-6
https://doi.org/10.22037/jhf.v3i2.8882
Abstract
Background: Iran, located in Eastern Mediterranean region, is one of the noteworthy centers for the prevalence of Beta-Thalassemia genetic disorder. The aim of this study was to investigate the relationship between Beta-globin gene mutations and blood factors in the carriers of Beta-Thalassemia. Materials and Methods: This descriptive study was to investigate the relationship between beta-globin gene mutations and the average volume of red blood cells in Beta-Thalassemia carriers referred to the health network. The study was conducted in Pakdasht and Varamin from 1997 to 2013. Ethical issues such as confidentiality of studied community were all considered. Results: In the present study, the relationship between some blood parameters of red blood cells, such as the mean volume of red blood cells (MCV), and the type of mutation in the beta-globin was analyzed. MCV was statistically related to the type of mutation (p=0.05). The mean and standard deviation values of MCV were 62.1 and 3.9, respectively.
Conclusion: The amount of MCV can be used as a guide for quick access to genetic mutations in Beta-Thalassemia carrier couples referred to Genetic centers before and during the pregnancy. Keywords: Thalassemia, Genetic disease, Mutation, Blood factors, Iran Iran, located in Eastern Mediterranean region, is one of the noteworthy centers for the prevalence of Beta-Thalassemia genetic disorder. The aim of this study was to investigate the relationship between Beta-globin gene mutations and blood factors in the carriers of Beta-Thalassemia.
Materials and Methods: This descriptive study was to investigate the relationship between beta-globin gene mutations and the average volume of red blood cells in Beta-Thalassemia carriers referred to the health network. The study was conducted in Pakdasht and Varamin from 1997 to 2013. Ethical issues such as confidentiality of studied community were all considered.
Results: In the present study, the relationship between some blood parameters of red blood cells, such as the mean volume of red blood cells (MCV), and the type of mutation in the beta-globin was analyzed. MCV was statistically related to the type of mutation (p=0.05). The mean and standard deviation values of MCV were 62.1 and 3.9, respectively.
Conclusion: The amount of MCV can be used as a guide for quick access to genetic mutations in Beta-Thalassemia carrier couples referred to Genetic centers before and during the pregnancy.
- Thalassemia, Genetic disease, Mutation, Blood factors, Iran
How to Cite
References
Relationship between β-globin gene mutations and blood factors in Beta- Thalassemia carriers
Hossein Hatami1, Soheila Khodakarim2, Fereydoon Faghani*3, Sedigheh Rastgar4
- MD-MPH, Department of Public Health, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- PhD, Department of Public Health, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- MSPH-MPH, Department of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- MD-MPH, Department of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
ABSTRACT
Background: Iran, located in Eastern Mediterranean region, is one of the noteworthy centers for the prevalence of
Beta-Thalassemia genetic disorder. The aim of this study was to investigate the relationship between Beta-globin
gene mutations and blood factors in the carriers of Beta-Thalassemia.
Materials and Methods: This descriptive study was to investigate the relationship between beta-globin gene
mutations and the average volume of red blood cells in Beta-Thalassemia carriers referred to the health network.
The study was conducted in Pakdasht and Varamin from 1997 to 2013. Ethical issues such as confidentiality of
studied community were all considered.
Results: In the present study, the relationship between some blood parameters of red blood cells, such as the mean
volume of red blood cells (MCV), and the type of mutation in the beta-globin was analyzed. MCV was statistically
related to the type of mutation (p=0.05). The mean and standard deviation values of MCV were 62.1 and 3.9,
respectively.
Conclusion: The amount of MCV can be used as a guide for quick access to genetic mutations in Beta-Thalassemia
carrier couples referred to Genetic centers before and during the pregnancy.
Keywords: Thalassemia, Genetic disease, Mutation, Blood factors, Iran
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