Chemotherapeutic Potential of Methanol Leaf Extract of Telfairia occidentalis on Oxidative Stress, Hepatic, Hematological, and Biochemical Alterations in DMBA-Induced Breast Cancer in Wistar Rats
Archives of Advances in Biosciences,
Vol. 16 No. 1 (2025),
2 March 2025
,
Page 1-7
https://doi.org/10.22037/aab.v16i1.49245
Abstract
Introduction: Telfairia occidentalis is a tropical plant widely grown in West Africa, traditionally used for treating several health issues. This study examined the effects of methanol and water extracts of T. occidentalis leaves on oxidative stress markers, liver function, blood parameters, and biochemical indices in Wistar rats with breast cancer induced by 7,12-dimethylbenz[a]anthracene.
Materials and Method: A randomized design was used with five groups of rats (10 per group), treated with T. occidentalis extracts at 100, 200, and 400 mg/kg doses. The methanol extract was prepared using Soxhlet extraction (1:8 plant: solvent ratio). DMBA (30 mg/kg in corn oil) was administered orally once weekly for 4 weeks. Standard techniques were applied for phytochemical screening and toxicity testing. Antioxidant enzymes, liver markers, blood cells, glucose, and cholesterol were analyzed.
Results: Phytochemical screening showed varied levels of bioactive compounds. No toxicity was noted up to 400 mg/kg. Results showed significant (p < 0.05) dose-dependent improvement: MDA, liver enzymes, WBC, glucose, and cholesterol levels decreased significantly, while SOD, CAT, and Hb levels increased in extract-treated rats compared to the cancer group.
Conclusion: The findings suggest that T. occidentalis leaves are rich in antioxidants and have liver-protective potential, making them a promising option for managing oxidative stress. The extract’s safety also supports its possible use in future clinical trials.
Introduction: Telfairia occidentalis is a tropical plant widely grown in West Africa, traditionally used for treating several health issues. This study examined the effects of methanol and water extracts of T. occidentalis leaves on oxidative stress markers, liver function, blood parameters, and biochemical indices in Wistar rats with breast cancer induced by 7,12-dimethylbenz[a]anthracene.
Materials and Method: A randomized design was used with five groups of rats (10 per group), treated with T. occidentalis extracts at 100, 200, and 400 mg/kg doses. The methanol extract was prepared using Soxhlet extraction (1:8 plant: solvent ratio). DMBA (30 mg/kg in corn oil) was administered orally once weekly for 4 weeks. Standard techniques were applied for phytochemical screening and toxicity testing. Antioxidant enzymes, liver markers, blood cells, glucose, and cholesterol were analyzed.
Results: Phytochemical screening showed varied levels of bioactive compounds. No toxicity was noted up to 400 mg/kg. Results showed significant (p < 0.05) dose-dependent improvement: MDA, liver enzymes, WBC, glucose, and cholesterol levels decreased significantly, while SOD, CAT, and Hb levels increased in extract-treated rats compared to the cancer group.
Conclusion: The findings suggest that T. occidentalis leaves are rich in antioxidants and have liver-protective potential, making them a promising option for managing oxidative stress. The extract’s safety also supports its possible use in future clinical trials.
- Telfairia occidentalis
- phytochemicals
- oxidative stress
- Liver Enzymes
- Toxicity
How to Cite
References
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