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  3. Vol. 16 No. 1 (2025): Continuous Volume
  4. Review Article

Vol. 16 No. 1 (2025)

March 2025

Exploring the Regulatory Role of Long Non-Coding RNA in Breast Cancer: A Review of Current Insights

  • Hafiz Muhammad Sultan
  • Rabail Mujahid
  • Habiba Ali
  • Ali Hassan
  • Mahnoor Mazhar

Archives of Advances in Biosciences, Vol. 16 No. 1 (2025), 2 March 2025 , Page 1-18
https://doi.org/10.22037/aab.v16i1.48811 Published: 2025-08-05

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Abstract

Context: The cancer epidemic is getting worse every day. Breast cancer is one of the leading causes of mortality worldwide, including in Pakistan. This condition is progressing due to a number of variables. According to recent investigations, lncRNAs play a major role in cancer development.

Evidence Acquisition: The post-surgical breast tissue samples were acquired by contacting different hospitals. The analysis of lncRNA expression profiles of publicly available breast cancer datasets will be done using overlapping Bioinformatics tools. To support the suggested mechanisms of lncRNA regulation in breast cancer, the experimental data will be compared.

Results: Almost 1900 lncRNA gene annotated in human genome so far (Gencode 41), which is almost equal to the number of genes that code for proteins. The effective characterization of lncRNAs remains a significant challenge in molecular biology, prompting numerous high-throughput initiatives and is a critical scientific priority. The great clinical potential that these molecules hold has sparked lncRNA research, which has been founded on the characterization of their expression and functional mechanisms.

Conclusion: This review depicted lncRNA role in breast cancer. Protein-coding genes and lncRNA are related to the development of breast cancer.

Keywords:
  • LncRNAs
  • Breast Cancer
  • gene expression
  • cancer biology
  • functional mechanism
  • molecular biology
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How to Cite

Sultan, H. M., Mujahid, R., Ali, H., Hassan, A., & Mazhar, M. M. (2025). Exploring the Regulatory Role of Long Non-Coding RNA in Breast Cancer: A Review of Current Insights. Archives of Advances in Biosciences, 16(1), 1–18. https://doi.org/10.22037/aab.v16i1.48811
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