Estimation of human absorbed dose of 99mTc-MAA using MIRD method based on animal data and comparison with MCNP simulation code Estimation of absorbed dose of 99mTc-MAA using MIRD and MCNP method
Archives of Advances in Biosciences,
Vol. 12 No. 1 (2021),
23 February 2021
,
Page 1-6
https://doi.org/10.22037/aab.v12i1.31788
Abstract
Introduction: 99mTc-Macro Aggregated-Albumin (99mTc-MAA) has been evaluated as a useful perfusion study agent. In this study, the human absorbed dose of 99mTc-MAA was estimated with MIRD and MCNP methods based on animal biodistribution data and finally compared with ICRP publication data.
Materials and Methods: In this study, for investigating the biodistribution of 99mTc-MAA, after radiolabeling of MAA with Technetium-99m, it was injected to mice via the tail vein. After 1-120 min post injection, the mice were sacrificed and some of their tissues dissected and counted for calculating the percentage of the injected dose per gram (% ID/g) and the absorbed dose. Then, the obtained data was converted to equivalent data in human for each tissue.
Results: Dose prediction shows that the highest absorbed dose is observed in the lungs (MIRD: 6.8E-2 mGy/MBq, MCNP: 6.32E-2 mGy/MBq). There is good agreement between the results obtained from MIRD and MCNP simulation for lungs.
Conclusion: According to the present results and comparison with ICRP publication data, animal dissection model and simulation MCNP code can be useful tools for internally-absorbed dose estimation of pulmonary radiopharmaceuticals.
- 99mTc, Macro aggregated albumin (MAA), MCNP simulation code, MIRD method, absorbed dose
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References
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