• Register
  • Login
  • English
    • فارسی

Tārīkh-i pizishkī i.e., Medical History

  • Home
  • About
    • About the Journal
    • Editorial Team
    • Indexing & Abstracting
  • Authors Guide
    • Commitment Form
    • Articles format
    • Orcid Code
  • Reviewing
  • COPE
    • Cope practices
  • Submission
  • Copyright Statement
  • Current
  • Archives
  • Contact
  • Announcements
Advanced Search
  1. Home
  2. Archives
  3. Vol. 12 No. 44 (1399): Medical History Journal: Autumn 2020; 12(44): e2
  4. Review Article

Vol. 12 No. 44 (1399)

November 2020

Doubts about the Effectiveness of Baking Soda Inhalation on Improving Respiratory Symptoms in COVID-19 Patients: A Review Article

  • Marzieh Beygom Siahpoosh
  • Aliakbar Habibi
  • Alireza Nikbakht Nasrabadi

Tārīkh-i pizishkī i.e., Medical History, Vol. 12 No. 44 (1399), 10 November 2020 , Page 1-15
https://doi.org/10.22037/mhj.v12i44.32194 Published: 2020-11-21

  • View Article
  • Download
  • Cite
  • References
  • Statastics
  • Share

Abstract

Background and Aim: Inhalation of nebulized baking soda (NaHco3) has been effective for reducing from inflammation intensity in some respiratory disorders. COVID-19 infection may result in ARDS through activation of inflammatory factors and has no certain treatment. Some time in cyberspace, inhalation of baking soda vapor has been recommended in order to prevent the development of COVID-19. The present study intends to answer this question that may inhalation of baking soda vapor be effective to control respiratory symptoms in COVID-19 patients?

Material and Methods: This is a review study. Searching key words in valid scientific databases and collecting contents related to the topic and finally qualitative analysis was the method of this study.

Findings: Through using nebulized drugs, aerosols enter to respiratory tract. According to particle size, some other physical characters and also respiratory tract factors, particles deposition in respiratory tract is different. In traditional (homemade) steam inhalation, aerosols are not produced and water vapor and vapor of other soluble substances, if they have the ability to evaporate in thus situation, enter to the respiratory tract. According to some studies, nebulized baking soda inhalation, not vapor of its solution in water, has reduced respiratory tract inflammation through elevating airway pH, increasing airway blood flow and reducing sputum viscosity, successfully. Evaporating of baking soda solution during traditional steam inhalation, result in producing carbon dioxide and water and there is no NaHco3 molecule in vapor.

Conclusion: No Sodium Bicarbonate molecule is produced from evaporating of NaHco3 solution through traditional (homemade) steam inhalation of baking soda; so, despite of nebulized baking soda which has NaHco3 molecule, evaporated baking soda solution could not show anti-inflammatory effects; so, theoretically, steam inhalation of baking soda could not be effective in COVID-19 infection. On the other hand, using inhaled drugs in COVID-19 infection may lead to further spread of the disease. So, using inhaled nebulized baking soda in COVID-19 patients should be studied for both its efficacy and its safety. 

 

Cite this article as: Siahpoosh MB, Habibi AA, Nikbakht Nasrabadi AR. Doubts about the Effectiveness of Baking Soda Inhalation on Improving Respiratory Symptoms in COVID-19 Patients: A Review Article. Medical History Journal 2020; 12(44): e3.

Keywords:
  • COVID-19 Baking; Soda Steam; Inhalation Sodium; Bicarbonate Aerosol; Respiratory Inflammation; Vapor
  • pdf (فارسی)

How to Cite

Siahpoosh, M. B., Habibi, A., & Nikbakht Nasrabadi, A. (2020). Doubts about the Effectiveness of Baking Soda Inhalation on Improving Respiratory Symptoms in COVID-19 Patients: A Review Article. Tārīkh-I Pizishkī i.E., Medical History, 12(44), 1–15. https://doi.org/10.22037/mhj.v12i44.32194
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

References

Sanders M. Inhalation therapy: an historical review. Prim Care Respir J 2007; 16(2): 71-81.

Rajabnejad MR, Pakzad AR, Pakzad P. Pharmacology and Therapies in Ancient Egypt. Med Hist J 2019; 11(39): 89-95. [Persian]

Pedersen S. Inhalers and nebulizers: which to choose and why. Respir Med 1996; 90: 69-77.

Dhanani J, Fraser JF, Chan HK, Rello J, Cohen J, Roberts JA. Fundamentals of aerosol therapy in critical care. Crit Care 2016; 20(1): 269.

Rubin BK. Air and Soul: The Science and Application of Aerosol Therapy. 36th Donald F Egan Scientific Memorial Lecture. Respir Care 2010; 55(7): 911-921.

Gaurav S, Pherwani MJ, Sandeep L. Herbal Nebulizer: A New Approach of Drug Administration. IAMJ 2015; 3(5): 1325-1331.

World Health Organization. WHO Director-General's opening remarks at the Mission briefing on COVID-19. Available at: https://www.who.int/dg/ speeches/detail/who-director-general-s-opening-rema rks-at-the-mission-briefing-on-covid-19. Accessed March 12, 2020.

Centers for Disease Control and Prevention. Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Disease (COVID-19). Available at: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-management-patients.html. Accessed April 3, 2020.

Aghili Khorasani M. Makhzn al advieh (collection of drugs). 1st ed. Tehran: Bavardaran; 2006. p.54. [Persian]

Sahai D. Evidence Brief: Humidifier use in health care. Ontario Agency for Health Protection and Promotion (Public Health Ontario). Toronto, ON: Queen’s Printer for Ontario; 2017. Available at: https://www.publichealthontario.ca/-/media/document s/eb-humidifier-hc.pdf?la=en. Accessed April, 2017.

Colbeck I, Lazaridis M. Aerosol Science: Technology and Applications. Wiley; 2013. Available at: https://www.wiley.com/en-us/Aerosol+Science%3A +Technology+and+Applications-p-9781119977926. Accessed Febuary, 2014.

Hess DR. Nebulizers: Principles and Performance. Respir Care 2000; 45(6): 609-622.

Ali M. Engineered Aerosol Medicine and Drug Delivery Methods for Optimal Respiratory Therapy. Respir Care 2014; 59(10): 1608-1610.

Thomas RJ. Particle size and pathogenicity in the respiratory tract. Virulence 2013; 4(8): 847-858.

Outbreak notice: Sodium Bicarbonate. Commercial. Available at: http://www.dcwltd.com/ PDF/Sahupuram/Sodium_Bicarbonate.pdf.

Clancy D, Patel-Jones J, Hutton G. Accelerated Stability Modeling: Investigation of Disintegration Time of a Drug Product with Sodium Bicarbonate. In: Qiu F, Scrivens G. Accelerated Predictive Stability. Academic Press; 2018. Available at: https://www. sciencedirect.com/topics/neuroscience/sodium-bicarb onate. Accessed May 18, 2018.

Keener TC, Frazier GC, Davis WT. Thermal Decomposition of Sodium Bicarbonate. Chemical Engineering Communications 1985; 33(1-4): 93-105.

Vinsel PJ. Treatment of acute chlorine gas inhalation with nebulized sodium bicarbonate. J Emerg Med 1990; 8(3): 327-329.

Bosse GM. Nebulized sodium bicarbonate in the treatment of chlorine gas inhalation. J Toxicol Clin Toxicol 1994; 32(3): 233-241.

Aslan S, Kandiş H, Akgun M, Cakir Z, Inandi T, Görgüner M. The effect of nebulized NaHCO3 treatment on "RADS" due to chlorine gas inhalation. Inhal Toxicol 2006; 18(11): 895-900.

Dobay O, Laub K, Stercz B, Kéri A, Balázs B, Tóthpál A, et al. Bicarbonate Inhibits Bacterial Growth and Biofilm Formation of Prevalent Cystic Fibrosis Pathogens. Front Microbiol 2018; 19(9): 2245.

Souza GCC, Francisco PPL, Jan CK, Mauch RM, Pessine FBT, Levy CE, et al. Safety, Tolerability and Effects of Sodium Bicarbonate Inhalation in Cystic Fibrosis. Clinical Drug Investigation 2020; 40: 105-117

El Badrawy MK, Elela MA, Yousef AM, Abou El-Khier NT, Abdelgawad TT, Abdalla DA, Moawad A. Effect of sodium bicarbonate 8.4% on respiratory tract pathogens. Chest Lung Res 2018; 1(1): 3-7.

El-Badrawya MK, Arram EO, Abdalla DA, Al-Sagheer D, Zahran A, AboElEla MA, et al. Effect of adding inhalation of sodium bicarbonate 8.4% to the usual treatment on smear-positive pulmonary tuberculosis: a prospective controlled study. Egypt J Bronchol 2019; 13(4): 531-538.

Kis A, Toth LA, Kunos L, Vasas S, Losonczy G, Mendes E, et al. The effect of airway alkalization by nebulized sodium bicarbonate on airway blood flow. European Respiratory Journal 2012; 40(suppl 56): 2143.

Outbreak notice: Iranian Association of Clinical Laboratory Doctors. Introduction and application of laboratory tests in Evaluation and management of Covid 19 disease. Available at: http://www.iacld.com/ Show/Page/4152. Accessed April 7, 2020. [Persian]

Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, Function and Antigenicity of the SARSCoV-2 Spike Glycoprotein. Cell 2020; 181(2): 281-292.

World Health Organization. COVID-19 virus persistence: Implications for transmission and precaution recommendations. Available at: https://www.who.int/docs/default-source/coronaviruse/ situation-reports/20200326-sitrep-66-covid-19.pdf?sfv rsn=9e5b8b48_2. Accessed Mar 26, 2020.

Outbreak notice: How Long Can COVID-19 Live on Surfaces? Available at: https://www.hub.jhu.edu/ 2020/03/20/sars-cov-2-survive-on-surfaces. Accessed Mar 20, 2020.

Doremalen NV, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med 2020; 382: 1564-1567.

Rezaeetalab F, Mozdourian M, Amini M, Javidarabsjahi Z, Akbari F. COVID-19: A New Virus as a Potential Rapidly Spreading in the Worldwide. J Cardiothorac Med 2020; 8(1): 563-564.

Wu J, Liu J, Zhao X, Liu C, Wang W, Wang D, et al. Clinical Characteristics of Imported Cases of COVID-19 in Jiangsu Province: A Multicenter Descriptive Study. Clin Infect Dis 2020; 71(15): 706-712.

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395: 507-513.

Gostic K, Gomez AC, Mummah RO, Kucharski AJ, Lloyd-Smith JO. Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19. eLife 2020; 9: e55570. Accessed Feb 24, 2020.

Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. Features, Evaluation and Treatment Coronavirus (COVID-19). In: StatPearls. StatPearls Publishing, Treasure Island (FL); 2020. Available at: http://www.creativecommons.org/licenses/by/4.0/. Accessed Apr 6, 2020.

Shi H, Han X, Jiang N, Cao Y, Alwalid O, Gu J, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: A descriptive study. Lancet Infect Dis 2020; 20(4): 425-434.

Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020; 8(4): 420-422.

Rabby I. Current Drugs with Potential for Treatment of COVID-19: A Literature Review. J Pharm Pharm Sci 2020; 23: 58-64.

Guo YR, Cao QD, Hong AS, Tan YY, Chen SD, Jin HJ, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res 2020; 7(1): 11.

Siahpoosh MB. How Can Persian Medicine (Traditional Iranian Medicine) Be Effective to Control COVID-19? Trad Integr Med 2020; 5(2): 46-48.

Siahpoosh MB. Clinical Improvement in a Case of COVID-19 with gastrointestinal manifestations through using Natural therapy based on Persian Medicine: A Case Report. Trad Integr Med 2020; 5(3): 114-118.

Niktabe Z, Masoudi N, Sharifi-Olounabadi A. Investigation the Pathogenesis of COVID-19 Virus Based on the Principles of Traditional Persian (Iranian) Medicine and Providing Proposed Contrivances for Prevention and Treatment. Med Hist J 2020; 12(42): 25-36. [Persian]

Bhootra BL, Kitinya J. Deaths from accidental steam inhalation during traditional therapy. J Clin Forensic Med 2005; 12(4): 214-217.

Baartmans M, Erkhof EK, Vloemans J, Dokter J, Nijman S, Tibboel D, Nieuwenhuis M. Nieuwenhuis. Steaminhalation therapy: Severe scalds as an adverse side effect. Br J Gen Pract 2012: e473-e477.

Murphy SM, Murray D, Smith S, Orr DJA. Burns caused by steam inhalation for respiratory tract infections in children. BMJ 2004; 328 (7442): 757.

Bierwirth P. Carbon dioxide toxicity and climate change: A major unapprehended risk for human health. Available at: https://www.researchgate.net/publication/ 311844520. Accessed May 14, 2020.

Outbreak notice: Overview of the acute health effects associated with carbon dioxide. Available at: https://www.epa.gov/sites/production/files/2015-06/ documents/co2appendixb.pdf.

Azumaa K, Kagi N, Yanagi U, Osawa H. Effects of low-level inhalation exposure to carbon dioxide in indoor environments: A short review on human health and psychomotor performance. Environment International 2018; 121(1): 51-56.

Rubin BK. Aerosol Medications for Treatment of Mucus Clearance Disorders. Respir Care 2015; 60(6): 825-832.

Vries LD, Griffiths A, Armstrong D, Robinson PJ. Cytokine gene polymorphisms and severity of CF lung disease. J Cyst Fibros 2014; 13: 699-705.

Ong EZ, Chan YFZ, Leong WY, Lee NMY, Kalimuddin S, Mohideen SMH, et al. A dynamic immune response shapes COVID-19 progression. Cell Host & Microbe 2020; 27: 1-4. Accessed April 30, 2020.

Shi Y, Wang Y, Shao C, Uang J, Gan J, Huang X, et al. COVID-19 infection: the perspectives on immune responses. Cell Death Differ 2020; 27: 1451-1454.

Wardeh A, Conklin J, Ko M. Case reports of observed significant improvement in patients with ARDS due to COVID-19 and maximum ventilatory support after inhalation of sodium bicarbonate. J Clin Intensive Care Med 2020; 5: 016-019.

Kallstrom TJ. Aarc Guideline: Bland Aerosol Administration. Respir Care 2003; 48(5): 529-533.

Outbreak notice: Inhalation Therapy for Suspected COVID-19 Patients. Available at: https://www.munson healthcare.org/media/file/Physician%20Services/COVID19/Communications/Inhalation%20Therapy%20for%20Suspected%20COVID-19%20Patients.pdf. Accessed March 17, 2020.

Whittle JS, Pavlov I, Sacchetti AD, Atwood C, Rosenberg MS. Respiratory support for adult patientswith COVID-19. JACEP Open 2020; 1(2): 95-101. Available at: https://www.researchgate.net/ publication/340407966. Accessed April 5, 2020.

Guzman MI. Bioaerosol Size Effect in COVID-19 Transmission. Preprints.org 2020. DOI: 10.20944/preprints202004.0093.v1. Available at: https://www.researchgate.net/publication/340492230. Accessed Apr 22, 2020.

Amirav I, Newhouse MT. Transmission of coronavirus by nebulizer: a serious, underappreciated risk. CMAJ 2020; 192(13): E346. Accessed March 30, 2020.

Liu Y, Ning Z, Chen Y, Guo M, Liu Y, Gali NK, et al. Aerodynamic Characteristics and RNA Concentration of SARS-CoV-2 Aerosol in Wuhan Hospitals. Nature 2020; 582: 557-560.

Tomoda Y, Murakami S, Kawaguchi K, Orihashi T, Tanaka K. Humidifier lung. QJM 2019; 112(5): 367-368.

Shimoda M, Morimoto K, Nakamoto K, Furuuchi K, Shirai T, Tanaka Y, et al. Humidifier lung: Characterization of features and comparison to other hypersensitivity pneumonitis phenotypes. Respirology 2018; 23(Suppl 2): 279.

  • Abstract Viewed: 156627 times
  • pdf (فارسی) Downloaded: 457 times

Download Statastics

  • Linkedin
  • Twitter
  • Facebook
  • Google Plus
  • Telegram

Information

  • For Readers
  • For Authors
  • For Librarians

Language

  • فارسی
  • English
  • Home
  • Archives
  • Submissions
  • About the Journal
  • Editorial Team
  • Contact

This magazine is an electronic magazine that is published in Persian along with an English abstract with open access.

Powered by OJSPlus