Background: C3 Glomerulopathy (C3G) is a rare clinical entity caused by Alternate complement pathway dysregulation. Limited published literature is available regarding clinical picture and outcome in Indian children. This study aims to Retrospectively analyze the clinicopathological spectrum and response to Mycophenolate Sodium (MPA) in the treatment of C3G.

Methods: Records of all patients ≤ 18 years diagnosed as C3G between Jan 2017 and Dec 2020 were retrieved after ethical approval. C3 GN and dense deposit disease (DDD) were diagnosed based on EM. Clinical features at presentation and outcomes in terms of response to MPA and death/kidney failure were evaluated. Improvement in  (eGFR) by 50% and spot urine protein creatinine ratio (UPCR) < 0.5g/g defined complete remission (CR). Remission was partial (PR) if eGFR improved by 50-25% and spot UPCR was 0.5-3.5g/g. No response was defined as improvement in eGFR by ≤25% and spot UPCR>3.5g/g.

Results:  22 children (9 boys) were diagnosed as C3 Glomerulopathy: C3 GN n=15 (68%) and DDD) n=7 (32%). Age at presentation (median, range) was 7.66,10 years and 9.28,7 years in C3GNand DDD respectively (P = 0.24). Acute nephritic syndrome was the commonest presentation in C3GN (8/15, 53%). Whereas rapidly progressive renal failure was more common in DDD (4/7, 57%). Nephrotic range proteinuria was more common in DDD (85%). All children received prednisolone. Eighteen children received MPA, 3 cyclophosphamide and 1 received cyclosporine. On MPA Ten (55%) had CR and 4 (22.3%) had PR. Four (22.2%) had no response. Out of 4 with no response 3 progressed to kidney failure, 1 expired. Response to treatment was poorer (NR 3, 75%) in children who did not receive MPA(p<0.05).

Conclusion:Children with DDD had more severe presentation and poorer outcome. MMF was useful in treating C3G patients with a higher probability of remission and lower probability of kidney failure.

Background and Aim: A renal length discrepancy (RLD) of more than 10 mm by ultrasound
(US) is accepted as a potential indicator of an underlying renal pathology. This study aimed to
determine the predictive value of RLD detected by US for identifying abnormal findings on
kidney radioisotope scans, specifically dimercaptosuccinic acid (DMSA) scans, in children.
Methods: The study involved a prospective data analysis of children who underwent renal
US and DMSA scans. The positive and negative predictive values for renal RLD were
calculated for values ranging from 6 to >10 mm.
Results: The left kidney was longer in 51.4% of cases, whereas the right kidney was longer in
35.7%; their lengths were equal in 12.9%. The results indicated that a specific degree of RLD
in the US could predict abnormalities on DMSA scans with varying degrees of accuracy,
depending on the age group. The cutoff ultrasound RLDs that resulted in the best specificity
and sensitivity for an abnormality on DMSA scan were ≥5 mm in children whose right kidney
was longer than the left, and ≥6 mm for children whose left kidney was longer than the right
(specificity of 88% and 84%, respectively).
Conclusion: Renal length discrepancy observed via ultrasound can be a valuable, noninvasive
tool in predicting renal abnormalities detectable by DMSA scan in children, aiding
clinical decision-making and potentially reducing the need for more invasive procedures.
However, ultrasound has moderate sensitivity and reasonable specificity for predicting
positive DMSA scan results and detecting high-grade vesicoureteral reflux (VUR).

Background and Aim: Children with end-stage chronic kidney disease on maintenance
hemodialysis (HD) are highly susceptible to infections (catheter-related, urinary tract, and
upper respiratory) and disturbances in calcium–phosphate (Ca×P) metabolism. Intradialytic
exercise has been proposed as a safe non-pharmacologic strategy to improve physical function
and reduce inflammation; however, data in pediatric populations remain scarce. This pilot
study aimed to evaluate the feasibility of an 8-week combined intradialytic exercise program
and explore its effects on the infection rate and the Ca×P product.
Methods: This quasi-experimental single-group pre–post pilot study was conducted in five
children (aged 8–18 years) with maintenance HD ≥2 months and a stable central venous
catheter. The intervention comprised supervised upper-limb resistance and supine cycling
exercise three times per week during HD sessions for 8 weeks. Infection events were recorded
using standardized clinical and laboratory criteria. Serum calcium and phosphate were
measured pre- and post-intervention; Ca×P product was calculated. Prepost Ca×P changes
were analyzed with a paired t-test; infection rates during exercise versus non-exercise months
were compared using the Mann–Whitney U test (P<0.05).
Results: All five participants completed the program. The mean Ca×P increased nonsignificantly
from 52.7±17.71 to 59.43±8.43 mg²/dL² (P=0.36). Mean monthly infection rate
was 10% during exercise months versus 16% during non-exercise months (P=0.673). The
exercise protocol was feasible and well-tolerated.
Conclusion: An 8-week combined intradialytic exercise program was feasible and safe in
pediatric patients with HD. It did not significantly alter infection rates or Ca×P product in this
small, underpowered pilot study. Larger randomized controlled trials are needed.

Background and Aim: Wide variations exist regarding different histopathological types
and treatment outcomes of idiopathic steroid-resistant nephrotic syndrome (iSRNS) in
children. This study has been conducted to evaluate clinicopathological profile and shortterm
outcomes of iSRNS in children and to analyze predictive factors for outcomes.
Methods: This cross-sectional observational study was conducted at a tertiary care hospital
in eastern India over a period of 18 months. Children with iSRNS aged 2–12 years, with
an available renal biopsy report, for whom treatment was started within six months, were
included. Data were collected at baseline and at 6 and 12-24 months.
Results: Of the 40 children with iSRNS (mean age: 1 year and 4 months; male: female
ratio: 1:1), 30% and 70% respectively had hematuria and hypertension at the onset of
nephrotic syndrome. Late SRNS was more common (55%) than initial SRNS (45%).
Before the development of late SRNS, the percentages of steroid-dependent, infrequent
relapsing and frequent relapsing nephrotic syndrome were 45.4%, 41% and 13.6%,
respectively. Focal segmental glomerulosclerosis (62.5%), minimal change nephrotic
syndrome (32.5%), and IgM nephropathy (5%) were the prevalent renal biopsy findings,
with no association to the clinical features or renal parameters. 75% of participants
received cyclosporine, and the rest received tacrolimus. The percentages of complete
remission, partial remission and no response at 6 months were 70%, 12.5% and 17.5%,
respectively; and at the end of 12–24 months they were 80%, 0% and 20%, respectively.
No predictive factors for outcome were found.
Conclusion: The present study explored the complex nature of iSRNS in children.
Development of SRNS cannot be predicted by any clinicopathological factors. Early age at
onset of NS and the presence of hypertension are likely indicators of subsequent development
of SRNS. A large percentage of iSRNS achieved complete remission with effective therapies
available in the era of modern medicine.

Background and Aim: Childhood idiopathic nephrotic syndrome (INS) needs long-term
treatment as well as frequent hospitalization. This study aimed to assess the economic impact
on families with childhood INS.
Methods: This cross‐sectional study was conducted on children aged 1–17 years with INS
in the Department of Pediatric Nephrology from January 2021 to December 2021. Baseline
demographic characteristics including age, gender, type of nephrotic syndrome, duration
of disease and treatment, number of hospitalizations, treatment costs, educational status of
parents, and socio-economic status using modified Kuppuswamy’s socio-economic status
scale 2021 were recorded. The economic impact of nephrotic syndrome on families was
assessed during parental interviews. Data were analyzed using SPSS software, version 19.
Results: Among the 63 families, most were in the upper-lower economic class (55.6%),
91.8% had to disrupt work, 61.9% had to bear expenses from more than one source, 65.6% in
which one family member needed to take on an additional job, 87.3% had to travel to another
district, 76.2% needed to spend money on accommodation for the accompanying person,
41% of families had to face moderate financial hardship and 14.8% had to face great financial
hardship, 28.15% had to take out a loan. There was no significant difference in the economic
impact on families among various INS subtypes.
Conclusion: Most families disrupted work, spent money from more than one source, had
family members take on additional jobs, faced moderate to great financial hardship, and
needed to take out loans.

Abstract:

Introduction:

Nephrotic syndrome is a disease requiring long duration of steroids as  treatment. In this study we are analysing various factors, in children with this condition, which would predict delayed remission, hence requiring longer courses of steroids.

Methods:

This is a retrospective study, in children under 18 years, with nephrotic syndrome. Two hundred and three admissions were analysed. Age, course of nephrotic syndrome, presence of hypertension, cholesterol levels >400mg/dl, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, hyponatraemia and hypoalbuminemia were considered. Correlation of these parameters to delay in achieving remission (> 7 days) were done, followed by multinomial logistic regression. The score formulated from the resulting coefficients, was then tested on 63 separate cases using Receiver Operator Curve (ROC), and Area Under Receiver Operator Curve (AUROC) .

Results:

Significant spearman correlation (rho) were seen with - presence of hypertension (0.347), course of nephrotic syndrome being frequently relapsing or steroid resistant (0.319) , neutrophil to lymphocyte ratio >1.5 (0.312), cholesterol levels > 400mg/dl (0.201) and  age > 10 years (0.201.

The multinomial logistic regression model showed coefficients of 2.81, 2.81, 1.98, 1.198, 1.063 for presence of hypertension, course of nephrotic syndrome, cholesterol level, Neutrophil to lymphocyte ratio and age, respectively.

A score of more than or equal to 4  predicted delayed remission, with a sensitivity and specificity of 85.6% and 83.7%. The AUROC of this score on a separate group of 63 children showed to be 0.835

Conclusion:

This score helps us to predict the cases of nephrotic syndrome, where delayed remissions occur, requiring prolonged courses of steroids, and hence leading to the ill effects of steroids.

Background and Aim: Vesicoureteral reflux (VUR) is the abnormal return of urine from the
bladder to the urethra and kidney. Muscle weakness means the decrease in muscle force. This
study aimed to evaluate the presence of clinically detectable muscle weakness and hypotonia
in children with VUR compared with children without reflux.
Methods: This research was a case-control study conducted at Amirkabir Hospital in Arak
City, Iran. A total of 117 children were enrolled and divided into two groups. The first group,
children with VUR confirmed by voiding cystourethrogram (VCUG) (N=58) and the second
group, children with normal VCUG findings (N=59) approved by urologists. The two groups
were then examined by a neurologist for hypotonia and muscle weakness. The information
obtained was recorded in the checklist.
Results: There was a significant difference in regards to the gender of the case and control
groups; however, no significant difference was observed regarding their age, birth weight,
birth order, and neonatal situation. None of the patients had a history of hypotonia or muscle
weakness. Out of the patients who had reflux, 16(27.58%) had right side reflux, 13(22.41%)
had left side reflux, and 29(50%) had double sided reflux.
Conclusion: No patient from either group had signs of hypotonia or muscle weakness.

Introduction:Common cold is a common disease among children. For symptomatic treatment of this disease, children should use drugs that have the least side effects. Since diphenhydramine is widely used in symptomatic treatment of these children, we have tried to examine the effect of this drug on the blood pressure of children with common colds .

Materials and Methods:This is a clinical trial that was performed on 110 children aged 2 to 18 years old who referred to Amir Kabir Hospital in Arak. Before and 24 to 72 hours after diphenhydramine administration at a dose of 1-5mg.kg , in these children, the blood pressure of children was measured with Citizen Digital Device (CH-456) and compared to existing standards. Data were analyzed by SPSS-23 software .

Results: The mean age of these children was 7.13 years and the standard deviation was 2.57. In this study, 50.9% were male children and 49.1% were girls. In the study of the systolic and diastolic blood pressure of these children, it was observed that the children's blood pressure increased in some of them, but this increase was not statistically significant .

Conclusion:According to the results of the recent study, it is concluded that despite the increase in blood pressure in children suffering from common colds using diphenhydramine, its use in children with colds is not obstructed .

Keywords: Blood pressure, Cold, Diphenhydramine

Background and Aim: Gastroenteritis is a common illness in the pediatric population
and can lead to dehydration and several related complications. Vitamin E is a fatsoluble
vitamin recognized for its antioxidant effects and its role in protecting cells from oxidative
damage. Because oxidative stress and inflammation may contribute to the progression of
gastrointestinal infections, vitamin E could potentially support recovery and improve clinical
outcomes. Therefore, this study aimed to assess whether vitamin E supplementation can
reduce the duration of treatment in children diagnosed with gastroenteritis.
Methods: In this randomized interventional study, 60 children aged 12 months to 13 years
with gastroenteritis were assigned to intervention or control groups using block randomization
with eight blocks. The intervention group received vitamin E for 10 days in addition to
standard therapy, while the control group received standard treatment alone. Blinding was
not possible due to the inability to prepare a suitable placebo and the involvement of the
researcher in the randomization process. Clinical outcomes—including diarrhea, vomiting,
abdominal pain, fever, and dehydration—were defined using standard clinical criteria and
assessed at baseline and after the treatment period using a structured checklist. Data were
analyzed using the SPSS software (version 23).
Results: The mean age of children in the vitamin E and control groups was 5.2 and 5.67
years, respectively. No significant differences were observed between the two groups in terms
of age or sex (P=0.106 and P=0.437, respectively). The duration of diarrhea, abdominal pain,
and anorexia were significantly shorter in the vitamin E group than in the control group
(P<0.0001). By contrast, the duration of fever, dehydration, and vomiting did not differ
significantly between the groups (P=0.810, P=0.536, and P=0.685, respectively).
Conclusion: Overall, the findings indicate that vitamin E reduces the duration of diarrhea,
abdominal pain, and anorexia in children with gastroenteritis but has no effect on the duration
of fever, dehydration, and vomiting.

Background and Aim: Pediatric acute kidney injury (AKI)’s incidence, etiology, and
outcomes are very diverse and influenced by factors, such as age, location, and clinical
situation. Emphasizing regional epidemiology and its underlying causes is crucial for
improving the identification and management of this insidious issue.
Methods: This retrospective study was done at the Pediatric Nephrology Department
of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, a
developing country in South Asia. It included AKI patients aged 28 days to 18 years who
attended outpatient and inpatient departments between July 1, 2022, and August 31, 2024.
Results: In a 24-month span, 356(27.05%) instances of AKI were detected, with 5 to 15
years (55.06%) being the most prevalent age range. The etiology of AKI was identified to be
prerenal in 154 cases (46.26%), renal in 170 instances (47.75%), and postrenal in 32 cases
(8.98%). Of the total number of patients, 290(81.46%) were managed with conservative
treatment, while 20(5.62%) required hemodialysis and 46(12.92%) required peritoneal
dialysis. Over a three-month period, 302 children (84.83%) remained alive, with 17(4.78%)
developing CKD, 22(6.18%) developing end-stage renal disease (ESRD), and 15(4.21%)
passed away (P<0.0001). The presence of anuria, volume overload, and primary renal
disease were identified as significant risk factors for beginning renal replacement therapy
(hemodialysis and peritoneal dialysis).
Conclusion: Pediatric AKI is mainly caused by gastroenteritis, sepsis, and rapidly progressive
glomerulonephritis (RPGN), which recover well at a single tertiary care center. Oliguria/
anuria, anemia, volume overload, failure (pRIFLE category) at presentation, and dialysis
necessity were correlated with unfavorable renal outcomes.

Background: Nephrotic syndrome (NS) affects 1.5 to 16.9% of children, with idiopathic cases categorized into minimal change and other types. Elevated serum immunoglobulin E (IgE) levels have been linked to frequent relapses and steroid dependency in both children and adults with minimal change NS.

Materials and Methods: This prospective cohort study included patients with NS. Serum samples for IgE levels were collected prior to initiating steroid therapy (2 mg/kg/day). Patients were discharged after achieving remission, following institutional protocols and ISPN guidelines. They were then categorized into high IgE and normal IgE groups, with characteristics compared. The number of relapses, complications, and any additional medications used during the study period were recorded.

Results: A total of 72 patients were included in the study. The mean serum IgE level was higher in the frequent relapser, steroid resistant, steroid dependent group as compared to the infrequent relapser and non-relapser group. All patients with poor response to steroid therapy and needing second line drugs had high serum IgE. In patients with a higher serum immunoglobulin E level the mean hospital stay duration was higher than in patients with a normal serum immunoglobulin E level (P=0.046). Patients with a higher serum IgE level had a higher incidence of infections, complications, poor response to therapy and use of second-line drugs (immunosuppressants), took longer time for remission. We got a significant correlation between the serum IgE levels and outcome (P<0.05)

Conclusion: Serum IgE levels were shown to be associated with disease activity and outcome in children with  primary NS.

Background and Aim: Chronic kidney disease (CKD) in children poses significant
psychological challenges for parents, potentially leading to elevated levels of stress, anxiety,
and depression. This study aimed to compare levels of stress, anxiety, health anxiety, and
depression between parents of children diagnosed with CKD and parents of healthy children.
Methods: This cross-sectional comparative study included 70 parents (35 parents of
children with chronic kidney disease and 35 parents of healthy children) recruited from Amir
Kabir Children’s Hospital in Arak, Iran. Psychological outcomes, including stress, anxiety,
depression, and health anxiety were assessed using the depression, anxiety, and stress scale
(DASS-21) and the 18-item health anxiety inventory (HAI-18). Statistical analyses was
performed using SPSS software, version 26.
Results: Parents of children with CKD reported significantly higher levels of anxiety
(P=0.044) and stress (P=0.047) compared to the control group. However, there were no
statistically significant differences in depression levels (P=0.117) or health anxiety (P=0.840).
Demographic variables showed no significant correlation with psychological outcomes.
Conclusion: Parents of children with CKD experience elevated levels of stress and anxiety,
underscoring the need for targeted psychological interventions to support their mental health.

Background and Aim: Urinary tract infections (UTIs) are among the most common
bacterial infections in children and adolescents. Despite standard antibiotic therapy, symptom
resolution can be delayed due to ongoing inflammation. Melatonin, a neurohormone with
known antioxidant and immunomodulatory properties, may offer therapeutic benefits in this
context. This study aimed to evaluate the clinical efficacy of adjunctive melatonin therapy in
pediatric patients with UTIs, focusing on symptom resolution and potential anti-inflammatory
effects.
Methods: In this double-blind, randomized, placebo-controlled trial, 100 children aged
4–18 years with confirmed UTI and concurrent sleep disturbances were assigned to receive
either melatonin (3 mg/day) plus antibiotics (intervention group) or antibiotics plus placebo
(control group) for 10 days. Primary outcomes included time to resolution of fever, dysuria,
abdominal pain, urinary frequency, and incontinence.
Results: Baseline characteristics were similar between groups. The melatonin group showed
significantly faster resolution of fever (1.3±0.49 vs 3.7±0.69 days, P=0.001), abdominal pain
(1.2±0.54 vs 3.62±0.67 days, P=0.001), and dysuria (1.5±0.57 vs 3.6±0.67 days, P=0.001).
No significant differences were observed in urinary frequency or incontinence outcomes. No
adverse effects related to melatonin were reported.
Conclusion: Adjunctive melatonin therapy appears to accelerate the resolution of key UTI
symptoms in children when combined with antibiotics, likely due to its anti-inflammatory
and antioxidant properties. These findings suggest a potential role for melatonin in pediatric
UTI management and warrant further investigation in larger, multicenter trials.

Background and Aim: Hypercalciuria, hyperoxaluria, hereditary renal tubular disorders,
and drug intoxication are the etiologies of nephrocalcinosis (NC) in children. This study
aimed to determine the etiologies and short-term outcomes (resolution rate) of NC.
Methods: Children aged ≤18 years with NC who were referred to the nephrology clinic of
an academic center from March 2003 to 2019 were considered for the study. The inclusion
criteria were measurement of serum creatinine, sodium, potassium, calcium, and phosphorus;
blood gas analysis; and random or 24-hour urine samples for creatinine and calcium levels.
Results: A total of 43 patients met the inclusion criteria. There were 21 girls (48.8%). The
median age of patients was two years (10 months to 8 years). They were followed up for
a median of 9 months (1-34 months). Most cases had medullary NC grade I (76.8%). The
most common etiologies of NC were unknown (41.8%), idiopathic hypercalciuria (34.9%),
and idiopathic hyperoxaluria (18.6%), respectively. Seven cases (16.3%) had mixed
abnormalities. Resolution of NC at a follow-up of ≥ one year was uncommon (20%).
Conclusion: Idiopathic hypercalciuria and idiopathic hyperoxaluria were the most common
identified etiologies. Hereditary tubular disorders accounted for 16.3% of the cases.
Resolution of NC was uncommon, even in NC grade I, at a follow-up of ≥ one year.

Background and Aim: Renal Angina Index (RAI), which combines risk strata and clinical
injury signs of acute kidney injury (AKI) helps identify sick paediatrics at risk of developing
severe AKI. This study aimed to estimate the proportion of critically ill children with a
positive RAI score at admission who develop severe AKI on day 3 of paediatric intensive
care unit (PICU) admission.
Methods: This prospective follow-up study was done among 100 children without
preexisting kidney disease and with at least 3 days of stay in the pediatric intensive care unit
of a tertiary care teaching hospital in South India. The RAI score was calculated at admission.
The KDIGO score was applied on day 3 of admission. The proportion of children with a
positive RAI score (8 or more) who developed severe AKI (the kidney disease: Improving
global outcomes [KDIGO] stages 2 and 3) was calculated. Short-term outcomes in terms of
duration of hospital stay and mortality were also studied.
Results: A total of 100 children aged 29 days to 12 years were included in the study. Fifty-one
percent of them were found to be RAI-positive at admission. Also, 41.2% of RAI-positive
children developed severe AKI on day 3 of admission. Among the 31% of children who were
diagnosed with severe AKI by day 3 of admission, 67.7% had a positive RAI score at the
time of admission (P<0.05). AKI was found to be associated with increased median duration
of hospital stay.
Conclusion: The RAI score can predict AKI in critically ill children.

Pediatric chronic kidney disease (CKD) represents a complex and evolving clinical entity with
profound implications for long-term morbidity and quality of life. Unlike adult CKD, where
the therapeutic focus often centers on dialysis adequacy and cardiovascular comorbidities,
pediatric CKD care necessitates a developmentally sensitive and growth-oriented approach.
One of the most critical, yet under-recognized, metabolic complications in this population is
persistent hyperphosphatemia—a state of phosphate overload that exerts pathophysiological
effects across skeletal, cardiovascular, endocrine, and neurological systems.
Phosphate is essential for multiple physiological processes, including skeletal mineralization,
energy metabolism via ATP synthesis, cellular signaling pathways, and the regulation
of acid-base balance. These specialized formulas
are designed to meet growing children’s full caloric, protein, and micronutrient needs while
minimizing the intake of inorganic and highly absorbable phosphate. This systematic review
explored the biochemical basis and clinical relevance of phosphate dysregulation in pediatric
CKD, delineated its systemic complications with an emphasis on growth and bone health,
and critically appraised the emerging role of hypophosphatemic formulas as a cornerstone therapeutic intervention. It synthesized findings from the current international clinical
guidelines—including KDIGO, KDOQI, and ESPEN—while identifying critical gaps in
pediatric-specific evidence. Moreover, it discussed the practical aspects of implementing
hypophosphatemic strategies, such as regional availability, cultural adaptability, formulation
palatability, and caregiver education.

Background and Aim: Nephrotic syndrome ranks as a prevalent chronic renal disorder
among children, leading to various challenges, including low blood albumin levels, swelling,
heightened infection risks, and dietary issues. The pivotal role of nursing interventions in
mitigating and managing these complications is undeniable. This research evaluated the
impact of nursing practices on managing nephrotic syndrome-related complications in
pediatric patients.
Methods: For this narrative review, studies from 2013 to 2025 were examined, utilizing
databases, such as Web of Science, PubMed, Scopus, SID, Magiran, and Google Scholar with
appropriate search terms.
Results: The findings indicated that critical nursing measures, such as educating parents,
consistent monitoring of fluid and electrolyte balance, skin care, dietary modifications, and
ongoing psychosocial support significantly contribute to lessening complication severity and
enhancing life quality for affected children.
Conclusion: The study underscores the critical importance of nurses in the holistic
management of nephrotic syndrome in children.

Background and Aim: Chronic kidney disease (CKD) is one of the most important problems
in children, sometimes associated with many co-morbid problems, such as intractable pain.
The pharmacokinetics of almost all analgesics are very different in CKD patients compared
to the normal population. Because of the accumulation of toxic metabolites, many of the
commonly used pain medications have more adverse effects and increased potential for
central nervous system toxicity.
Case Presentation: We reported an eleven-year-old girl affected by end-stage renal disease
(ESRD) due to focal segmental glomerolosclerosis (FSGS) nephrotic syndrome who
presented with decreased level of consciousness, behavioral dysfunction, and neurological
complications following a small dose of codeine consumption.
Conclusion: Even small doses of codeine can lead to severe, prolonged neurotoxicity in
pediatric ESRD. Appropriate drug selection and dosing in patients with CKD is necessary
to ensure optimal outcomes and avoid unwanted complications. Prescribing a standard dose
of analgesics without consideration of the patient’s renal function state may cause serious
complications.

Background and Aim: Membrane attack complex deficiency accounts for 10-15% of cases
of complement dysregulation-associated hemolytic uremic syndrome (HUS).
Case Presentation: We report a case involving a 7-year-old girl who presented with HUS.
Assessment of the complement pathway revealed persistently low levels of CD46. Initially,
she required kidney replacement therapy, but following partial recovery of renal function, she
was able to discontinue therapy for several years. During this period, she was admitted multiple
times for pneumonia, hypertensive crises, and relapses of her underlying condition, which
were managed accordingly. Whole-exome sequencing revealed a mutation in the membrane
cofactor protein (MCP; CD46). At the age of 12.5 years, she was readmitted with fever and
dyspnea, during which a coronary artery aneurysm was detected via echocardiography.
Treatment with intravenous immunoglobulin, corticosteroids, and aspirin was initiated
to prevent thrombosis. Unfortunately, she passed away after three years of irregular and
inconsistent follow-up. To the best of our knowledge, the occurrence of a coronary artery
aneurysm has not been previously reported in association with CD46 deficiency.
Conclusion: In conclusion, the integration of cardiac markers and echocardiography into the
routine assessment of patients with cHUS is essential for monitoring potential cardiovascular
complications.

Background and Aim: Kidney biopsies are seldom performed these days in neonates,
especially after the advent of advanced antenatal imaging and the widespread availability of
genetic studies.
Case Presentation: We described a newborn with kidney failure, for whom a biopsy was
conducted, leading to a diagnosis of glomerulo cystic kidney disease.
Conclusion: Sporadic glomerulocystic kidney disease can manifest as renal failure during
the newborn period. Renal biopsy may be used to diagnose glomerulocystic kidney disease
in this setting.

Background and Aim: Hematuria in an infant is not very uncommon. Nephrocalcinosis
and renal stones frequently cause hematuria and urinary tract infections in early infancy.
Furthermore, xanthinuria is a rare metabolic disorder that can lead to the abnormal
accumulation of xanthine, resulting in nephrocalcinosis and the subsequent formation
of renal stones. It is an autosomal recessive genetic disorder caused by a lack of xanthine
dehydrogenase, which breaks down hypoxanthine and xanthine into uric acid in the final two
steps of the purine degradation process. Only a few instances have been noted worldwide.
Furthermore, pediatric xanthinuria has never been reported from Bangladesh.
Case Presentation: Herein, we discussed a 2-month-old male infant who had symptoms of
excessive crying during micturition and microscopic hematuria, later diagnosed as a case of
xanthinuria type 1.
Conclusion: Hereditary xanthinuria may present with hematuria and nephrocalcinosis.
Confirmation by genetic testing is useful for identifying the type of hereditary xanthinuria
and predicting the outcomes.

Background and Aim: Multisystem inflammatory syndrome in children (MIS-C) is a
serious condition in which a patient (typically infected with severe acute respiratory syndrome
coronavirus 2 [SARS-CoV-2]) manifests symptoms of multiorgan failure a few weeks after
exposure due to broad adaptive and innate immune activation. This case report demonstrates
that MIS-C can occur in the context of a postoperative surgical site infection (SSI) following
orthopedic surgery.
Case Presentation: A 13-year-old boy with a history of multiple trauma and subsequent
lower limb fracture followed by orthopedic surgery presented to the emergency department
with SSI. After 6 days of admission, the patient developed symptoms of multisystem
inflammatory syndrome, including renal shutdown and elevated blood creatinine (Cr) levels.
As a result, hemodialysis was performed. The patient’s blood culture was negative, and
similar clinical situations (such as sepsis and toxic shock) were ruled out during orthopedic
surgery and infectious disease specialties’ consultations.
Conclusion: MIS-C can emerge not only secondary to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection but also can be triggered by SSI secondary to
orthopedic surgeries. Regular organ function monitoring in patients with SSI complications
can be very beneficial in early diagnosis and preventing complications.

This letter aims to bring focus to the important
connection between vitamin D
deficiency and nephrotic syndrome (NS)
in children, an area deserving greater clinical
and investigative priority [1]. Pediatric
NS, characterized by significant proteinuria, hypoalbuminemia,
and edema, continues to be a major contributor
to illness among children. Although corticosteroid
therapy is the primary treatment, frequent disease flares
and steroid dependence often worsen long-term prognosis,
highlighting the importance of managing associated
treatable conditions.

I hope this message finds you in good
health. I would like to express my sincere
appreciation for your continued efforts to
maintain the scientific quality and integrity
of the journal and for your dedication to advancing
pediatric nephrology research and academic discourse.
I read with great interest the article entitled "The Relationship
Between Serum Vitamin D3 Levels and Recurrent
Urinary Tract Infection in Children." This study
addresses an important clinical question and contributes
meaningfully to the existing literature on pediatric urinary
tract infections and vitamin D status.
However, I would like to raise two methodological
points that may require clarification.