Multisystem Inflammatory Syndrome in Children Secondary to Surgical Site Infection: A Case Report Multisystem Inflammatory Syndrome in Children Secondary to Surgery
Journal of Pediatric Nephrology,
Vol. 13 (2025),
12 May 2026
https://doi.org/10.22037/jpn.v13i1.50713
Abstract
Background and Aim: Multisystem inflammatory syndrome in children (MIS-C) is a
serious condition in which a patient (typically infected with severe acute respiratory syndrome
coronavirus 2 [SARS-CoV-2]) manifests symptoms of multiorgan failure a few weeks after
exposure due to broad adaptive and innate immune activation. This case report demonstrates
that MIS-C can occur in the context of a postoperative surgical site infection (SSI) following
orthopedic surgery.
Case Presentation: A 13-year-old boy with a history of multiple trauma and subsequent
lower limb fracture followed by orthopedic surgery presented to the emergency department
with SSI. After 6 days of admission, the patient developed symptoms of multisystem
inflammatory syndrome, including renal shutdown and elevated blood creatinine (Cr) levels.
As a result, hemodialysis was performed. The patient’s blood culture was negative, and
similar clinical situations (such as sepsis and toxic shock) were ruled out during orthopedic
surgery and infectious disease specialties’ consultations.
Conclusion: MIS-C can emerge not only secondary to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection but also can be triggered by SSI secondary to
orthopedic surgeries. Regular organ function monitoring in patients with SSI complications
can be very beneficial in early diagnosis and preventing complications.
- Multisystem inflammatory syndrome in children (MIS-C)
- Surgical wound infection
- Multiple trauma
- Limb fracture
How to Cite
References
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