Serum Immunoglobulin E levels as a prognostic marker in children with primary nephrotic syndrome Prognostic value of serum IgE in pediatric primary NS
Journal of Pediatric Nephrology,
Vol. 13 No. 1 (2025),
12 Ordibehesht 2026
https://doi.org/10.22037/jpn.v13i1.48749
Abstract
Background: Nephrotic syndrome (NS) affects 1.5 to 16.9% of children, with idiopathic cases categorized into minimal change and other types. Elevated serum immunoglobulin E (IgE) levels have been linked to frequent relapses and steroid dependency in both children and adults with minimal change NS.
Materials and Methods: This prospective cohort study included patients with NS. Serum samples for IgE levels were collected prior to initiating steroid therapy (2 mg/kg/day). Patients were discharged after achieving remission, following institutional protocols and ISPN guidelines. They were then categorized into high IgE and normal IgE groups, with characteristics compared. The number of relapses, complications, and any additional medications used during the study period were recorded.
Results: A total of 72 patients were included in the study. The mean serum IgE level was higher in the frequent relapser, steroid resistant, steroid dependent group as compared to the infrequent relapser and non-relapser group. All patients with poor response to steroid therapy and needing second line drugs had high serum IgE. In patients with a higher serum immunoglobulin E level the mean hospital stay duration was higher than in patients with a normal serum immunoglobulin E level (P=0.046). Patients with a higher serum IgE level had a higher incidence of infections, complications, poor response to therapy and use of second-line drugs (immunosuppressants), took longer time for remission. We got a significant correlation between the serum IgE levels and outcome (P<0.05)
Conclusion: Serum IgE levels were shown to be associated with disease activity and outcome in children with primary NS.
- Serum IgE
- Nephrotic Syndrome
- Relapse
- Children
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References
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