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  3. Vol. 13 No. 1 (2025): Continuous 2025
  4. Original Research Papers

Vol. 13 No. 1 (2025)

May 2026

The Comparison Of Prevalence Of Muscle Weakness And Hypotonia Between Children With And Without Vesicoureteral Reflux

  • Amirirfan Malik

Journal of Pediatric Nephrology, Vol. 13 No. 1 (2025), 12 May 2026
https://doi.org/10.22037/jpn.v13i1.50758 Published: 2026-05-12

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Abstract

Background and Aim:

Vesicoureteral reflux is the abnormal return of urine from the bladder to the urethra and kidney. Muscle weakness means the decrease in muscle force. Due to witnessing uremic myopathy in patients with kidney diseases we will study the relation between muscle weakness and reflux nephropathy in this article.

Methods:

In this case control study, a total number of 118 patients referred to Amirkabir hospital in the city of Arak were divided into two groups. The first group, patients with reflux disease(N=59) and the second group, healthy patients(N=59) based on VCUG results approved by urologists. The two groups were then examined by a neurologist for hypotonia and muscle weakness. The information obtained was recorded in the checklist

 

Results:

There was a significant difference in regards to the gender of the case and control groups, however no significant difference was observed regarding their age, birth weight, birth rate and neonatal situation. None of the patients had a history of hypotonia or muscle weakness. Out of the patients who had reflux, 16(22.7%) had right side reflux, 13(22.4%) had left side reflux and 29(50%) had double sided reflux.

 

 

Conclusion:

No patient from either group had signs of hypotonia or muscle weakness.

Keywords:
  • Vesicoureteral reflux, muscle weakness, hypotonia

How to Cite

1.
Malik A. The Comparison Of Prevalence Of Muscle Weakness And Hypotonia Between Children With And Without Vesicoureteral Reflux. J Ped Nephrol [Internet]. 2026 May 12 [cited 2026 Jul. 8];13(1). Available from: https://journals.sbmu.ac.ir/jpn/article/view/50758
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References

1. Evengard B, Schacterle RS, Komaroff AL. Chronic fatigue syndrome: new insights and old ignorance. J Intern Med. 1999;246(5):455-69.

2. Tekgul S, Riedmiller H, Hoebeke P, Kocvara R, Nijman RJ, Radmayr C, et al. EAU guidelines on vesicoureteral reflux in children. Eur Urol. 2012;62(3):534-42.

3. Skoog SJ, Peters CA, Arant BS, Jr., Copp HL, Elder JS, Hudson RG, et al. Pediatric Vesicoureteral Reflux Guidelines Panel Summary Report: Clinical Practice Guidelines for Screening Siblings of Children With Vesicoureteral Reflux and Neonates/Infants With Prenatal Hydronephrosis. J Urol. 2010;184(3):1145-51.

4. Bocquet N, Sergent Alaoui A, Jais JP, Gajdos V, Guigonis V, Lacour B, Cheron G. Randomized trial of oral versus sequential IV/oral antibiotic for acute pyelonephritis in children. Pediatrics. 2012;129(2):e269-75.

5. Atala A, Cima LG, Kim W, Paige KT, Vacanti JP, Retik AB, Vacanti CA. Injectable alginate seeded with chondrocytes as a potential treatment for vesicoureteral reflux. J Urol. 1993;150(2 Pt 2):745-7.

6. Levey AS, de Jong PE, Coresh J, El Nahas M, Astor BC, Matsushita K, et al. The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report. Kidney Int. 2011;80(1):17-28.

7. Ford CE, Hamerton JL. A colchicine, hypotonic citrate, squash sequence for mammalian chromosomes. Stain Technol. 1956;31(6):247-51.

8. Hungerford DA. Leukocytes cultured from small inocula of whole blood and the preparation of metaphase chromosomes by treatment with hypotonic KCl. Stain Technol. 1965;40(6):333-8.

9. m KJM. nelson essentials of pediatrics. 7 ed2015.

10. Sargent MA. What is the normal prevalence of vesicoureteral reflux? Pediatr Radiol. 2000;30(9):587-93.

11. Lebowitz RL. The detection and characterization of vesicoureteral reflux in the child. J Urol. 1992;148(5 Pt 2):1640-2.

12. Wingen AM, Koskimies O, Olbing H, Seppanen J, Tamminen-Mobius T. Growth and weight gain in children with vesicoureteral reflux receiving medical versus surgical treatment: 10-year results of a prospective, randomized study. International Reflux Study in Children (European Branch). Acta Paediatr. 1999;88(1):56-61.

13. Menon P, Rao KL, Bhattacharya A, Mahajan JK, Samujh R. Primary vesicoureteral reflux: progress of disease, somatic growth and renal parameters. Indian Pediatr. 2004;41(10):1025-30.

14. Yousefi P, Cyrus A, Dorreh F, Ahmadi M. Comparing the sacral ratio in children with various degrees of vesicoureteral reflux with children without reflux. Journal of Arak University of Medical Sciences. 2007;10(3):94-100.

15. W d. radiology review manual: Wolters kluwer Health/Lippincott Williams Wilkins2011.

16. Lebowitz RL, Olbing H, Parkkulainen KV, Smellie JM, Tamminen-Mobius TE. International system of radiographic grading of vesicoureteric reflux. International Reflux Study in Children. Pediatr Radiol. 1985;15(2):105-9.

17. M r. Nelson textbook of pediatrics2011.

18. chronic kidney disease in children medscape [Available from: https://emedicine.medscape.com/article/984358-overview?form=fpf.

19. chronic kidney disease [Available from: https://emedicine.medscape.com/article/238798-overview?form=fpf.

20. marx j. rosen's emergency medicine: concepts and clinical practice. philadelphia PA: Mosby/Elsevier; 2010.

21. SD ER. Neurobiology of muscle fatigue.: J Appl physiol; 1992.

22. Swaiman KF As, Ferreiro DM. pediatric neurology: principles and practice: Mosby/Elsevier; 2006.

23. H. o. orthopedics made rediculously simple(mesdmaster rediculously simple): medmaster inc; 2008.

24. Serratrice G, Toga M, Roux H, Murisasco A, de Bisschop G. [Neuropathies, myopathies and neuromyopathies in chronic uremic patients]. Presse Med (1893). 1967;75(37):1835-8.

25. Campistol JM. Uremic myopathy. Kidney Int. 2002;62(5):1901-13.

26. Fahal IH. Uraemic sarcopenia: aetiology and implications. Nephrol Dial Transplant. 2014;29(9):1655-65.

27. Visser M, Kritchevsky SB, Goodpaster BH, Newman AB, Nevitt M, Stamm E, Harris TB. Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study. J Am Geriatr Soc. 2002;50(5):897-904.

28. Rantanen T. Muscle strength, disability and mortality. Scand J Med Sci Sports. 2003;13(1):3-8.

29. Pournasiri Z, Madani A, Zandi H, Salehpour S, Abdollah Gorji F, Ahmadzahe A. Relationship of generalized joint hypermobility with vesicoureteral reflux and urinary tract infection. Iran J Kidney Dis. 2014;8(3):189-93.

30. Beiraghdar F, Rostami Z, Panahi Y, Einollahi B, Teimoori M. Vesicourethral reflux in pediatrics with hypermobility syndrome. Nephrourol Mon. 2013;5(4):924-7.

31. Pooli AH, Aran S, Farhoud AR, Saidian L, Kajbafzadeh AM. Concomitant vesicoureteral reflux and gastroesophageal reflux: an analytic cross-sectional study. Int Urol Nephrol. 2012;44(2):327-34.

32. Chang YT, Wu HL, Guo HR, Cheng YY, Tseng CC, Wang MC, et al. Handgrip strength is an independent predictor of renal outcomes in patients with chronic kidney diseases. Nephrol Dial Transplant. 2011;26(11):3588-95.

33. Flisinski M, Brymora A, Elminowska-Wenda G, Bogucka J, Walasik K, Stefanska A, et al. Morphometric analysis of muscle fibre types in rat locomotor and postural skeletal muscles in different stages of chronic kidney disease. J Physiol Pharmacol. 2014;65(4):567-76.

34. Pellizzaro CO, Thome FS, Veronese FV. Effect of peripheral and respiratory muscle training on the functional capacity of hemodialysis patients. Ren Fail. 2013;35(2):189-97.

35. Tavana S, Hashemian SM, Jahromi FK. Effect of Dialysis on Maximum Inspiratory and Expiratory Pressures in End Stage Renal Disease Patients. Tanaffos. 2015;14(2):128-33.

36. Rocha CB, Araujo S. Evaluation of maximum respiratory pressures in chronic renal patients at the pre and post hemodialysis moment. J Bras Nefrol. 2010;32(1):105-11.

37. Berretta JS, Holbrook CT, 3rd, Haller JS. Chronic renal failure presenting as proximal muscle weakness in a child. J Child Neurol. 1986;1(1):50-2.

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