Archives of Advances in Biosciences

Abstract

Currently cancer is considered as one of the main factors of mortality globally. Many chemicals in our environment can cause genetic mutations and are potentially responsible for millions of cancer-related deaths. Nowadays the scientists are looking for food materials which can potenthially prevent the cancer occurrence. The purpose of this research is to examine antimutagenicity and anticancer effect of Citrus nobilis . The Citrus nobilis  was subsequenthy evaluated in terms of antimutagenicity properties by a standard reverse mutation assay (Ames Test). This was performed with histidine auxotroph strain of Salmonella typhimurium(TA100) .Thus, it requires histidine from a foreign supply to ensure its growth.The aforementioned strain gives rise to reverted colonies when expose to carcinogen substance (Sodium Azide). In Ames Test the Citrus nobilis prevented the reverted mutations and the hindrance percent of Citrus nobilis was 72.46% . This is the first study that have revealed antimutagenicity effect of Citrus nobilis.