The Effect of Wet Cupping on Transforming Growth Factor-β1 in Patients with Migraine
Tārīkh-i pizishkī i.e., Medical History,
Vol. 10 No. 34 (1397),
25 November 2019
,
Page 85-94
https://doi.org/10.22037/mhj.v10i34.24839
Abstract
Background and Aim: Bleeding and cupping or 'wet cupping' have been used in medicine since ancient times in the treatment of inflammatory disorders. Recent studies show its useful effects on migraine and sciatica. Some researches show TGF-β1 involvement in immuno-regulation of inflammatory diseases. Aim of this study was to show if wet cupping have any effect on serum TGF-β1 concentration of patients with migraine and sciatica.
Materials and Methods: To measure serum TGF-β1 concentration, serum of thirty two (6 male and 26 female) patients and twenty two (4 male 18 female) healthy controls was taken and frozen before and one week after the 3rd treatment. The TGF-β1 concentration was measured by ELISA method.
Findings: TGF-β1 levels decreased significantly in the serum of patients after wet cupping (p<0.001). TGF-β1 levels in healthy subjects did not change significantly after wet cupping (p=0.776). The rate of TGF-β1 in patients was higher than healthy subjects (p<0.05).
Conclusion: This study shows wet cupping has a significant effect on TGF-β1 secretion in migraine patients. Given the key role of this cytokine in regulating inflammation in the central nervous system, it seems that wet cupping may help to relieve the disease.
Please cite this article as: Sheikhi AK, Raoofinezhad M, Ghotb SM, Karimi H, Sheikhi M, Sheikhi R, Moosavinasab SN. The Effect of Wet Cupping on Transforming Growth Factor-β1 in Patients with Migraine. Med Hist J 2018; 10(34): 85-94.
- Wet Cupping, Migraine, Cytokine, Inflammation, Iranian Traditional Medicine, TGF-β1
How to Cite
References
Kerridge IH, Lowe M. Bloodletting: the story of a therapeutic technique. Med J Aust 1995; 163(11-12): 631-633.
Arend WP. Inhibiting the effects of cytokines in human diseases. Adv Intern Med 1995, 40: 365-694.
Cavaillon JM. Contribution of cytokines to inflammatory mechanisms. Pathol Biol 1993; 41(8 Pt 2): 799-811.
Kaki A, Sawsan R, Samiha M, Al-Jaouni S, Elalah MA, Ibrahim N. Wet Cupping Reduces Pain and Improves Health-related Quality of Life Among Patients with Migraine: A Prospective Observational Study. Oman Med J 2019; 34(2): 105-109.
Longoni M, Ferrarese C. Inflammation and excitotoxicity: Role in migraine pathogenesis. Neurol Sci 2006; 27(Suppl 2): 107-110.
Goadsby PJ. The vascular theory of migraine a great story wrecked by the facts. Brain 2009; 132(Pt 1): 6-7.
Theoharides TC, Donelan J, Kandere-Grzybowska K, Konstantinidou A. The role of mast cells in migraine pathophysiology. Brain Res Brain Res Rev 2005; 49(1): 65-76.
Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, Moskowitz MA. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 2002; 8(2): 136-142.
Waeber C, Moskowitz MA. Migraine as an inflammatory disorder. Neurology 2005; 64(10 Suppl 2): 9-15.
Kemper RH, Meijler WJ, Korf J, Ter Horst GJ. Migraine and function of the immune system: A meta-analysis of clinical literature published between 1966 and 1999. Cephalalgia 2001; 21(5): 549-557.
Cseh A, Farkas KM, Derzbach L, Muller K, Vasarhelyi B, Szalay B, et al. Lymphocyte subsets in pediatric migraine. Neurol Sci 2013; 34(7): 1151-1155.
Sheikhi A, Giti H, Heibor MR, Jafarzadeh A, Shakerian M, Baharifar N, et al. Lactobacilus Delbrueckii subsp. Bulgaricus Modulates the Secretion of Th1/Th2 and Treg Cell-Related Cytokines by PBMCs from Patients with Atopic Dermatitis. Drug Res (Stuttg) 2017; 67(12): 724-729.
Sheikhi A, Shakerian M, Giti H, Baghaeifar M, Jafarzadeh A, Ghaed V, et al. Probiotic Yogurt Culture Bifidobacterium Animalis Subsp. Lactis BB-12 and Lactobacillus Acidophilus LA-5 Modulate the Cytokine Secretion by Peripheral Blood Mononuclear Cells from Patients with Ulcerative Colitis. Drug Res (Stuttg) 2016; 66(6): 300-305.
Sheikhi A, Azarbeig M, Karimi H. Autohemotherapy in chronic urticaria: what could be the autoreactive factors and curative mechanisms? Ann Dermatol 2014; 26(4): 526-527.
Yilmaz IA, Ozge A, Erdal ME, Edgünlü TG, Cakmak SE, Yalin OO. Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation. Pain Med 2010; 11(4): 492-497.
Lu Y, Boer J, Barsova RM, Favorova O, Goel A, Müller M, et al. Procardis Cardiogram Consortium. TGFB1 genetic polymorphisms and coronary heart disease risk: A meta-analysis. BMC Med Genet 2012; 13(2012): 39.
Yan X, Liu Z, Chen Y. Regulation of TGF-beta signaling by Smad7. Acta Biochim Biophys Sin (Shanghai) 2009; 41(4): 263-272.
Sheikhi A, Saadati K, Salmani R, Yahaghi N, Sheikhi A, Siemens DR. In vitro modulation of natural killer activity of human peripheral blood mononuclear cells against prostate tumor cell line. Immunopharmacol Immunotoxicol 2011; 33(4): 700-708.
Sharifi F, Sheikhi A, Behdad M, Mousavinasab N. Effect of garlic on serum adiponectin and interleukin levels in women with metabolic syndrome. Int J Endocrinol Metab 2010; 8(2): 68-72.
Sheikhi A, Nazarian M, Khadem Al-Melleh A, Nasab NM, Esmaeilzadeh A, Yahaghi N, et al. In-vitro effects of Mycobacterium bovis BCG-lysate and its derived heat shock proteins on cytokines secretion by blood mononuclear cells of rheumatoid arthritis patients in comparison with healthy controls. Int Immunopharmacol 2008; 8(6): 887-892.
Sheikhi AK, Tayade C, Paffaro VA, Croy BA. Are nutural killer cells distributed in relationship to nerve fibers in the pregnant mouse uterus? Pak J Biol Sci 2007; 10(17): 2885-2889.
Sheikhi AK, Yahya Jaberi Y, Khani M, Moosaeefard M, Shafaqatian M. The effect of cardiovascular drugs on pro-inflammatory cytokine secretion and natural killer activity of peripheral blood mononuclear cells of patients with chronic heart failure in vitro. Pak J Biol Sci 2007; 10(10): 1580-1587.
Benli AR, Sunay D. Changing Efficacy of Wet Cupping Therapy in Migraine with Lunar Phase: A Self-Controlled Interventional Study. Med Sci Monit 2017; 23): 6162-6167.
Inoue K, Yamazaki H, Manabe Y, Fukuda C, Hanai K, Fushiki T. Transforming growth factor-beta activated during exercise in brain depresses spontaneous motor activity of animals. Relevance to central fatigue. Brain Res 1999; 846(2): 145153.
Ishizaki K, Takeshima T, Fukuhara Y, Araki H, Nakaso K, Kusumi M, et al. Increased plasma transforming growth factor-beta1 in migraine. Headache 2005; 45(9): 1224-1228.
Bruno PP, Carpino F, Carpino G, Zicari A. An overview on immune system and migraine. Eur Rev Med Pharmacol Sci 2007; 11(4): 245-248.
- Abstract Viewed: 331 times
- PDF (فارسی) Downloaded: 229 times