Journal of Dental School

Vol. 44 No. 1 (2026)

Low-Fat Spindle Cell Lipoma of Oral Cavity: Report of a Rare Case

Journal of Dental School, Vol. 44 No. 1 (2026), 29 December 2025 , Page e14
https://doi.org/10.22037/jds.v44i1.50268

Abstract

Objective(s): Spindle cell lipoma (SCL) is a rare variant of lipoma that is uncommon in oral cavity which displays as a slow-growing, painless mass. The histopathologic diagnosis is challenging especially in low-fat/fat-free subtypes, and immunohistochemical staining is of great help in differential diagnosis. The current study aimed to report a rare case of low-fat SCL. Case: A 38-year-old male with a relatively large lesion on buccal mucosa was referred. The interventions included excisional biopsy, H&E staining, and immunohistochemical examinations. H&E study showed a peripheral soft tissue tumor. The underlying connective tissue showed collections of fatty tissue intermixed with spindle cell proliferations. In IHC study, Spindle cells were stained strongly and diffusely for CD34, and no S100 staining was detected in neoplastic spindle cells. Toluidine blue staining showed mast cells that were detected throughout the connective tissue. These findings confirmed the diagnosis of low-fat SCL. Conclusion: Oral pathologists should be familiar with the clinicopathologic characteristics of this rare lesion in order to avoid misdiagnosis.

Keywords:
  • Spindle Cell Lipoma
  • Oral cavity
  • Lipoma
  • Low-Fat

How to Cite

Atarbashi-Moghadam, S., Lotfi, A., Eftekhari-Moghadam, P., & Hassanizadeh, R. (2026). Low-Fat Spindle Cell Lipoma of Oral Cavity: Report of a Rare Case. Journal of Dental School, 44(1), e14. https://doi.org/10.22037/jds.v44i1.50268

References

1. Pires FR, Souza L, Arruda R, Cantisano MH, Picciani BL, Dos Santos TC. Intraoral soft tissue lipomas: clinicopathological features from 91 cases diagnosed in a single Oral pathology service. Med Oral Patol Oral Cir Bucal. 2021; 26 (1): e90-6. doi: 10.4317/medoral.24023

2. Rocha AFL, Miotto LN, Ferrisse TM, Silveira HA, Almeida LY, Bufalino A, et al. Low-fat and fat-free spindle cell lipomas in the oral cavity: Immunohistochemical analysis and review of the literature. J Cutan Pathol. 2019; 46(10):778-83. doi: 10.1111/cup.13512

3. Naruse T, Yanamoto S, Yamada S, Rokutanda S, Kawakita A, Takahashi H, et al. Lipomas of the oral cavity: clinicopathological and immunohistochemical study of 24 cases and review of the literature. Indian J Otolaryngol Head Neck Surg. 2015; 67(Suppl 1):67-73. doi: 10.1007/s12070-014-0765-8

4. Mousa AH, Nukaly HY, Mohamed REA, AlShehabi N, Daoud RM, Alsayed AW, et al. Spindle cell lipoma of the tongue: First case report from the Gulf region and review of the literature. Clin Case Rep. 2023;11(10): e8080. doi: 10.1002/ccr3.8080

5. Enzinger FM, Harvey DA: Spindle cell lipoma. Cancer. 1975; 36: 1852–59. doi: 10.1002/1097-0142(197511)36:5<1852::aid-ncr2820360542>3.0.co;2-u

6. Ali Hamouda S, Raouf Amin N, Ahmad Kotat H. Spindle Cell Lipoma: A Case Report and Review. Advanced Dental Journal. 2024;6(3): 445-9. doi: 10.21608/adjc.2023.239340.1399

7. Stojanov IJ, Mariño-Enriquez A, Bahri N, Jo VY, Woo SB. Lipomas of the Oral Cavity: Utility of MDM2 and CDK4 in Avoiding Overdiagnosis as Atypical Lipomatous Tumor. Head Neck Pathol. 2019; 13(2):169-76. doi: 10.1007/s12105-018-0928-0

8. Billings SD, Folpe AL. Diagnostically challenging spindle cell lipomas: a report of 34 ‘‘low-fat’’ and ‘‘fat-free’’ variants. Am J Dermatopathol. 2007;29:437–42. doi: 10.1097/DAD.0b013e31813735df

9. Dos Santos JL, Ocamoto EA, Almeida LY, Teixeira LR, Ribeiro-Silva A, León JE. Low-fat plexiform spindle cell lipoma with prominent myxoid stroma: an unusual oral presentation and immunohistochemical analysis. J Craniofac Surg. 2017;28:e158–60. doi: 10.1097/SCS.0000000000003348

10. Forcucci JA, Sugianto JZ,Wolff DJ, Maize Sr JC, Ralston JS. ‘‘Low-fat’’ pseudoangiomatous spindle cell lipoma: a rare variant with loss of 13q14 region. Am J Dermatopathol. 2015;37:920–3. doi: 10.1097/DAD.0000000000000286

11. Biagiotti J, Khan K, Ayrapetyan M, Wood J, Bhatt N. Fat-free spindle cell lipoma of the scalp: lipoma without a lipogenic component. J Craniofac Surg. 2022;33(4):e429-31. doi: 10.1097/SCS.0000000000008359

12. Lemos IZ, Cabral LR, de Souza NS, Medeiros PA, Pires FR. Large intraoral spindle cell lipoma. J Clin Exp Dent. 2021 1; 13(8): e845-e848. doi: 10.4317/jced.58405

13. Yanai Y, Kubota Y, Kitsuki T, Yanai R, Yamada T. Spindle cell lipoma of the floor of mouth. Radiol Case Rep. 2023;18(5):1662-5. doi: 10.1016/j.radcr.2023.01.091

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