Serum Level of 25-Hydroxy Vitamin D in an Iranian Subpopulation with Oral Squamous Cell Carcinoma with Different Histopathological Grades
Journal of Dental School,
Vol. 44 No. 1 (2026),
29 December 2025
,
Page e20
https://doi.org/10.22037/jds.v44i1.47175
Abstract
Objective(s): Emerging research indicates that vitamin D may exert antioxidant properties and potentially contribute to reducing the likelihood of cancer development. Multiple studies have indicated that inadequate vitamin D status is linked to a higher incidence of certain cancers, including colorectal and breast malignancies. This study aimed to investigate serum vitamin D concentrations in patients diagnosed with oral squamous cell carcinoma (OSCC) across different histopathological grades and to compare these levels with those of healthy subjects. Methods: The present case–control study consisted of 40 individuals with OSCC and 40 age- and sex-matched healthy participants. Serum samples of all participants were analyzed for vitamin D concentration using the enzyme-linked immunosorbent assay (ELISA) method. The collected data were evaluated using the independent t-test and Chi-square test at p<0.05. Results: Serum vitamin D concentrations were markedly lower among patients with OSCC compared with the control group. Moreover, elevated concentrations of vitamin D were associated with a lower risk of OSCC occurrence. This inverse association reached statistical significance in patients with grade I tumors, whereas no significant relationship was observed in grades II and III. In addition, tumor site showed no significant association with histopathological grade. Conclusion: These findings suggest that adequate serum vitamin D levels may contribute to reducing the risk of OSCC.
- Squamous Cell Carcinoma of Head and Neck
- Cancer
- Histopathology
- Oral
- Vitamin D
- Iran
How to Cite
References
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