Efficacy of Antimicrobial Agents in Orthodontic Adhesive Systems and Brackets: A Narrative Review
Journal of Dental School,
Vol. 37 No. 4 (2019),
10 October 2020
,
Page 112-117
https://doi.org/10.22037/jds.v37i4.31940
Abstract
Objectives: Development of white spot lesions (WSLs) in the course of orthodontic treatment would compromise the satisfaction of patients and clinicians. One suggested preventive strategy is to incorporate antimicrobial agents into orthodontic adhesive systems or to coat brackets with them. Several clinical and experimental studies have evaluated the effect of antimicrobial agents, but no consensus has been reached on the best preventive approach. Thus, the aim of this narrative review was to assess the clinical and experimental studies on the effect of incorporation of antimicrobial agents in orthodontic adhesives and brackets.
Methods: PubMed (Medline), Scopus, and Google Scholar were searched for related articles published from 1990 to 2020. Both clinical and experimental studies were included in this review.
Results: Different antimicrobial agents can be added to adhesive systems to control the formation of WSLs, and also preserve the bond strength of adhesives. Same as adhesive systems, coating of brackets with antibacterial agents can be performed to control bacterial proliferation and demineralization of enamel.
Conclusion: Antimicrobial agents incorporated in bonding systems or used for coating of brackets can confer antimicrobial properties with no significant negative effect on bonding properties. However, clinical and long-term studies are required to confirm their effectiveness and absence of side effects.
- antimicrobial
- orthodontics
- adhesive
- bracket
How to Cite
References
Ogaard B, Bishara S, Duschner H. Enamel effects during bonding-debonding and treatment with fixed appliances. Risk management in orthodontics: experts' guide to malpractice. Quintessence Chicago 2004:19-46.
Aykut-Yetkiner A, Kara N, Ateş M, Ersin N, Ertuğrul F. Does casein phosphopeptide amorphous calcium phosphate provide remineralization on white spot lesions and inhibition of Streptococcus mutans? J Clin Pediatr Dent 2014 Summer ;38(4):302-6.
Livas C, Kuijpers-Jagtman AM, Bronkhorst E, Derks A, Katsaros C. Quantification of white spot lesions around orthodontic brackets with image analysis. Angle Orthod 2008 Jul;78(4):585-90.
Arora V, Kundabala M, Parolia A, Thomas MS, Pai V. Comparison of the shear bond strength of RMGIC to a resin composite using different adhesive systems: An in vitro study. J Conserv Dent 2010 Apr;13(2):80-3.
Lippitz SJ, Staley RN, Jakobsen JR. In vitro study of 24-hour and 30-day shear bond strengths of three resin–glass ionomer cements used to bond orthodontic brackets. Am J Orthod Dentofacial Orthop 1998 Jun;113(6):620-4.
Meehan MP, Foley TF, Mamandras AH. A comparison of the shear bond strengths of two glass ionomer cements. Am J Orthod Dentofacial Orthop 1999 Feb;115(2):125-32.
Rogers S, Chadwick B, Treasure E. Fluoride-containing orthodontic adhesives and decalcification in patients with fixed appliances: a systematic review. Am J Orthod Dentofacial Orthop 2010 Oct;138(4):390. e1-8.
Uysal T, Amasyali M, Ozcan S, Koyuturk AE, Sagdic D. Effect of antibacterial monomer-containing adhesive on enamel demineralization around orthodontic brackets: An in-vivo study. Am J Orthod Dentofacial Orthop 2011 May;139(5):650-6.
Wang X, Wang B, Wang Y. Antibacterial orthodontic cement to combat biofilm and white spot lesions. Am J Orthod Dentofacial Orthop 2015 Dec;148(6):974-81.
Metin-Gürsoy G, Taner L, Akca G. Nanosilver coated orthodontic brackets: in vivo antibacterial properties and ion release. Eur J Orthod 2017 Feb;39(1):9-16.
Sharon E, Sharabi R, Eden A, Zabrovsky A, Ben-Gal G, Sharon E, et al. Antibacterial activity of orthodontic cement containing quaternary ammonium polyethylenimine nanoparticles adjacent to orthodontic brackets. Int J Environ Res Public Health. 2018 Mar ;15(4):606.
Liu Y, Zhang L, Niu LN, Yu T, Xu HHK, Weir MD, et al. Antibacterial and remineralizing orthodontic adhesive containing quaternary ammonium resin monomer and amorphous calcium phosphate nanoparticles. J Dent 2018 May;72:53-63.
Sodagar A, Bahador A, Pourhajibagher M, Ahmadi B, Baghaeian P. Effect of addition of curcumin nanoparticles on antimicrobial property and shear bond strength of orthodontic composite to bovine enamel. J Dent (Tehran) 2016 Sep;13(5):373-382.
Salehi P, Babanouri N, Roein-Peikar M, Zare F. Long-term antimicrobial assessment of orthodontic brackets coated with nitrogen-doped titanium dioxide against Streptococcus mutans. Prog Orthod 2018 Sep;19(1):35.
Ramazanzadeh B, Jahanbin A, Yaghoubi M, Shahtahmassbi N, Ghazvini K, Shakeri M, et al. Comparison of antibacterial effects of ZnO and CuO nanoparticles coated brackets against Streptococcus mutans. J Dent (Shiraz) 2015 Sep;16(3):200-5.
Altmann ASP, Collares FM, Ogliari FA, Samuel SMW. Effect of methacrylated-based antibacterial monomer on orthodontic adhesive system properties. Am J Orthod Dentofacial Orthop 2015 Apr;147(4 Suppl):S82-S7.
Oz AZ, Oz AA, Yazıcıoglu S. In vivo effect of antibacterial and fluoride-releasing adhesives on enamel demineralization around brackets: A micro-CT study. Angle Orthod 2017 Nov;87(6):841-6.
Swapna G, Sharma S, Soni VP, Tamgadge S. Demineralization adjacent to orthodontic brackets with fluoride releasing and conventional bonding agents. Indian J Dent Res 2016 Jul-Aug;27(4):426-32.
Yu F, Dong Y, Yu HH, Lin PT, Zhang L, Sun X, et al. Antibacterial activity and bonding ability of an orthodontic adhesive containing the antibacterial monomer 2-methacryloxylethyl hexadecyl methyl ammonium bromide. Sci Rep 2017 Feb ;7:41787.
Ma Y, Zhang N, Weir MD, Bai Y, Xu HHK. Novel multifunctional dental cement to prevent enamel demineralization near orthodontic brackets. J Dent 2017 Sep;64:58-67.
Eslamian L, Borzabadi-Farahani A, Karimi S, Saadat S, Badiee MR. Evaluation of the shear bond strength and antibacterial activity of orthodontic adhesive containing silver nanoparticle, an in-vitro study. Nanomaterials (Basel) 2020 Jul ;10(8):1466.
Yassaei S, Nasr A, Zandi H, Motallaei MN. Comparison of antibacterial effects of orthodontic composites containing different nanoparticles on Streptococcus mutans at different times. Dental Press J Orthod 2020 Mar-Apr;;25(2):52-60.
Yaseen SN, Taqa AA, Al-Khatib AR. The effect of incorporation Nano Cinnamon powder on the shear bond of the orthodontic composite (an in vitro study). J Oral Biol Craniofac Res 2020 Apr ;10(2):128-134.
Andriani A, Purwanegara MK. Effect of titanium dioxide nanoparticle addition into orthodontic adhesive resin on enamel microhardness. J Phys Conf Ser. 2017 Agu;884(1):012115.
Degrazia FW, Altmann ASP, Ferreira CJ, Arthur RA, Leitune VCB, Samuel SMW, et al. Evaluation of an antibacterial orthodontic adhesive incorporated with niobium-based bioglass: an in situ study. Braz Oral Res 2019 Jan;33:e010.
Jasso-Ruiz I, Velazquez-Enriquez U, Scougall-Vilchis RJ, Lara-Carrillo E, Toral-Rizo VH, López-Castañares R, et al. Synthesis and Characterization of Silver Nanoparticles on Orthodontic Brackets: A New Alternative in the Prevention of White Spots. Coatings. 2019 Jul;9(8):480.
Sonesson M, Bergstrand F, Gizani S, Twetman S. Management of post-orthodontic white spot lesions: an updated systematic review. Eur J Orthod 2017 Apr;39(2):116-21.
Norevall LI, Marcusson A, Persson M. A clinical evaluation of a glass ionomer cement as an orthodontic bonding adhesive compared with an acrylic resin. Eur J Orthod 1996 Aug;18(4):373-84.
Mattousch TJH, Van Der Veen MH, Zentner A. Caries lesions after orthodontic treatment followed by quantitative light-induced fluorescence: a 2-year follow-up. Eur J Orthod 2007 Jun;29(3):294-8.
Shungin D, Olsson AI, Persson M. Orthodontic treatment-related white spot lesions: a 14-year prospective quantitative follow-up, including bonding material assessment. Am J Orthod Dentofacial Orthop 2010 Aug;138(2):136. e1-8; discussion 136-7.
Khoroushi M, Kachuie M. Prevention and treatment of white spot lesions in orthodontic patients. Contemp Clin Dent 2017 Jan-Mar;8(1):11-9.
Turner PJ. The clinical evaluation of a fluoride-containing orthodontic bonding material. Br J Orthod 1993 Nov;20(4):307-13.
Banks PA, Burn A, O'Brien K. A clinical evaluation of the effectiveness of including fluoride into an orthodontic bonding adhesive. Eur J Orthod. 1997 Aug;19(4):391-5.
Millett DT, McCluskey LA, McAuley F, Creanor SL, Newell J, Love J. A comparative clinical trial of a compomer and a resin adhesive for orthodontic bonding. Angle Orthod. 2000 Jun;70(3):233-40.
Vahid-Dastjerdi E, Borzabadi-Farahani A, Pourmofidi-Neistanak H, Amini N. An in-vitro assessment of weekly cumulative fluoride release from three glass ionomer cements used for orthodontic banding. Prog Orthod. 2012 May;13(1):49-56.
Mattick CR, Mitchell L, Chadwick SM, Wright J. Fluoride-releasing elastomeric modules reduce decalcification: a randomized controlled trial. J Orthod. 2001 Sep;28(3):217-9.
Bishara SE, Ostby AW. White spot lesions: formation, prevention, and treatment. Semin Orthod 2008 Sep;14(3):174-82.
de Almeida CM, da Rosa WLO, Meereis CTW, de Almeida SM, Ribeiro JS, da Silva AF, et al. Efficacy of antimicrobial agents incorporated in orthodontic bonding systems: a systematic review and meta-analysis. J Orthod 2018 Jun;45(2):79-93.
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