Publisher: Shahid Beheshti University of Medical Sciences
  • Submission
  • Register
  • Login

Journal of Dental School

  • Home
  • About
    • About the Journal
    • Journal Metrics
    • Editorial Team
    • Aims & Scope
    • Indexing & Abstracting
    • Open Access
    • Publication Fees
    • Privacy Statement
  • Articles & Issues
    • Current
    • Archive
    • Accepted Manuscripts
  • Policies & Process
    • Peer Review Process
    • Complaints And Appeals
    • Conflicts of Interest
    • Data and Reproducibility
    • Plagiarism
    • Post Publication
    • Misconducts
    • Preprint
    • Archiving
    • Editorial Independence
    • Copyright
  • For Authors
    • Authorship
    • Forms
    • Ethical Guidelines and Considerations
    • Reporting Guidelines
  • Submission
    • Submit a New Manuscript
    • Track Your Submission
    • Instructions for Authors
    • Download Original Article Template
    • Download Title Page Form
    • Download Publishing Agreement Form
  • Register
  • Contact
Advanced Search
  1. Home
  2. Archives
  3. Vol. 33 No. 1 (2015): Winter
  4. Original Article

Vol. 33 No. 1 (2015)

March 2015

Comparison Study on Casein Phosphopeptide-Amorphous Calcium Phosphate Paste and Fluoride Gel on Remineralization of Demineralized Enamel Lesions

  • Leila Pishehvar
  • Romina Mazaheri
  • Mahboobeh Mirzakhani
  • Mohammad Hassan Nazari
  • Fatemeh sadat Ranjbaran

Journal of Dental School, Vol. 33 No. 1 (2015), 7 March 2015 , Page 80-87
https://doi.org/10.22037/jds.v33i1.24756 Published: 2019-03-11

  • View Article
  • Download
  • Cite
  • References
  • Statastics
  • Share

Abstract

Objective: Tooth surface undergoes continuous remineralization and demineralization. The aim of this study was to compare the effect of Caseinphosphopeptide-amorphous calcium phosphate (CPP- ACP) paste and Fluoride gel on the microhardness of demineralized enamel lesions.

Methods: Frothy eight specimens of premolar teeth were chosen and randomly divided to 4 groups of 12. After the initial measurement of micro-hardness the specimens were immersed in demineralizing solution for 4 day and then the measurements were recorded again. Two groups (GL and G3) were treated with CPP-ACP and Fluoride gel respectively according to manufacturer’s instruction. Two other groups (G2 and G4) were treated with CPP-ACP and fluoride gel every week for three months. After the treatments all specimens were taken into PH-cycling and the micro- hardness for each one were measured again. For data analysis, the Repeated Measures ANOVA test and the LSD tests were performed. In each group the percentage of micro-hardness recovery was measured.

Results: Repeated Measures ANOVA and LED Test showed that the mean value of hardness was significantly decreased after demineralization in all groups (p=0.01). There was no significant difference in mean hardness value in groups (GL, G3) after treatment (p=0.1, p=0.12) In groups (G2, G4) the mean hardness value were significantly increased (p<0.0001, p=0.1). It is noticeable that the CPP-ACP was significantly more efficient than the fluoride gel.

Conclusion: CPP-APC paste and fluoride gel both increase the micro-hardness of enamel when administrated for long time and repeated application.

Keywords:
  • Dental Enamel
  • Private office
  • Tooth Demineralization
  • Tooth Remineralization
  • PDF

How to Cite

Pishehvar, L., Mazaheri, R., Mirzakhani, M., Nazari, M. H., & Ranjbaran, F. sadat. (2019). Comparison Study on Casein Phosphopeptide-Amorphous Calcium Phosphate Paste and Fluoride Gel on Remineralization of Demineralized Enamel Lesions. Journal of Dental School, 33(1), 80–87. https://doi.org/10.22037/jds.v33i1.24756
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

References

Yamaguchi K, Miyazaki M, Takamizawa T, Inage H, Moore BK. Effect of CPP-ACP paste on Remineralization of demineralized enamel lesions mechanical properties of bovine enamel as determined by an ultrasonic device. J Dent 2006; 34: 230-236.

Silverstone LM, Hicks MJ, Featherstone MJ. Dynamic factors affecting lesion initiation and progression in human dental enamel. II. Surface morphology of sound enamel and caries like lesions of enamel. Quintessence Int 1988; 19: 773-785.

Lata S, Varghese NO, Varughese JM. Remineralization potential of fluoride and amorphous calcium phosphate-casein phospho peptide on enamel lesions: An in vitro comparative evaluation. J Conserv Dent 2010; 13: 42-46.

Ten Cate JM. In vitro studies on the effects of fluoride on de- and remineralization. J Dent Res. 1990; 69: 614-619.

Roberson TM. Cariology: the lesion, ethiology, prevention and control. In: Roberson TM, Heymann HO, Swift EJ. Sturdevant’s art and science of operative dentistry. 5th Ed. St Louis: The C. V. Mosby Co. 2006; Chap 3: 67-134.

White JM, Eakle WS. Rational and treatment approach in minimally invasive dentistry. J Am Dent Assoc 2000: 131: 13S-19S.

Oshiro M, Yamaguchi K, Takamizawa T, Inage H, Watanabe T, Irokawa A, et al. Effect of CPP- ACP paste on tooth mineralization: an FE-SEM study. J Oral Sci 2007; 49: 115-120.

Reynolds EC. Remineralization of enamel subsurface lesions by casein phosphopeptide-stabilized calcium phosphate solutions. J Dent Res 1997; 76: 1587-1595.

Ramalingam L, Messer LB, Reynolds EC. Adding casein phosphopeptide amorphous calcium phosphate to sports drinks to eliminate in vitro erosion. Pediatr Dent 2005; 27: 61-67.

Rahiotis C, Vougiouklakis G. Effect of a CPP-ACP agent on the demineralization and remineralization of dentin in vitro. J Dent 2007; 35: 695-698.

Rose RK. Effects of an anticariogenic casein phosphopeptide on calcium diffusion in streptococcal model dental plaques. Arch Oral Biol 2000; 45: 564-575.

Rose RK. Binding characteristics of streptococcus mutans for calcium and case in phosphopeptide. Caries Res 2000; 34: 427-431.

Azarpajhooh A, Limeback H. Clinical efficacy of casein derivative: a systematic review of the literature. J Am Dent Assoc 2008; 139: 915-924.

Featherstone JD, Ten Cate JM, Shariati M, Arends J. Comparison of artificial caries like lesions by quantitative microradiography and microhardness profiles. Caries Res. 1983; 17(5): 385-91.

Gerrard WA, Winter PJ. Evaluation of toothpastes by their ability to assist rehardening of enamel in vitro. Caries Res 1986; 20: 209-216.

Hegde MN, Moany A. Remineralization of enamel subsurface lesions with casein phosphopeptide-amorphous calcium phosphate: A quantitative energy dispersive X-ray analysis using scanning electron microscopy: An in vitro study. J Conserv Dent 2012; 15: 61-67.

Srinivasan N, Kavitha M, Loganathan SC. Comparison of the remineralization potential of CPP- ACP and CPP-ACP with 900 ppm fluoride on eroded human enamel: An in situ study. Arch Oral Biol 2010; 55: 541-544.

Panich M, Poolthong S. The effect of casein phosphopeptid-amorphous calcium phosphate and a cola soft drink on in vitro enamel hardness. J Am Dent Assoc 2009; 140: 455-460.

Kim MJ, Lee SH, Lee NY, Lee IH. Evaluation of the effect of PVA tape supplemented with 2.26% fluoride on enamel demineralization using microhardness assessment and scanning electron microscopy: In vitro study. Arch Oral Biol 2013; 58: 160-166.

Pulido MT, Wefel JS, Hernandez MM, Denehy GE, Guzman-Armstrong S, Chalmers JM, et al. The inhibitory effect of MI paste, fluoride and a combination of both on the progression of artificial caries like lesions in enamel. Oper Dent 2008; 33: 550-555.

Agnihotri Y, Pragada NL, Patri G, Thajuraj PK. The effect of CPP-ACP on remineralization of artificial caries like lesions: An in vitro study. Indian J Multi disciplinary Dent 2012; 2: 366-369.

Maleki-pour MR, Shirani F, Mirzakoochaki P, FazelKalbasi Z. Changes in bleached enamel microhardness after application of fluoride and CPP-ACP. The Journal of Islamic Dental Association of Iran 2012; 24: 25-30.

Kumar VL, Itthagarun A, King NM. The effect of casein phosphopeptide-amorphous calcium phosphate on remineralization of artificial caries -like lesions: An in vitro study. Aust Dent J. 2008; 53: 34-40.

  • Abstract Viewed: 209 times
  • PDF Downloaded: 188 times

Download Statastics

  • Linkedin
  • Twitter
  • Facebook
  • Google Plus
  • Telegram

Developed By

Open Journal Systems

Information

  • For Readers
  • For Authors
  • For Librarians

Make a Submission

Make a Submission
  • Home
  • Archives
  • Submissions
  • About the Journal
  • Editorial Team
  • Contact

e-ISSN: 2645-4351

Creative Commons License

This journal is open access and available under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license (https://creativecommons.org/licenses/by-nc-nd/4.0/).

 
Powered by OJSPlus