Review of Oral and Dental Consideration in the Patients with Head and Neck Radiotherapy and Chemotherapy
Journal of Dental School,
Vol. 36 No. 3 (2018),
30 December 2018
,
Page 108-114
https://doi.org/10.22037/jds.v36i3.24544
Abstract
Objectives Aggressive cancer therapy places patients at a greater risk for oral complications. Cancer patients suffer from oral toxic effects secondary to antineoplastic therapy (radiotherapy and chemotherapy). The aim of this review is management of the head and neck cancer patients that specifically emphasizes the prevention and treatment of oral and dental complications associated with cancer therapy.
Methods In this narrative review article, the specialized databases such as PubMed, PubMed Central, MEDLINE, EBSCO, Science Direct, Scopus from 2008 to 2018 were used to find relevant documents by using Mesh terms: Chemotherapy, Radiotherapy, oral consideration, head and neck.
Results The data were categorized in: Complications of head and neck radiotherapy and its management (Xerostomia, Oral Infection, Oral Mucositis, Osteoradionecrosis), Complications of head and neck chemotherapy and its management (Mucosal toxicity, Dental alterations, Neurological disorders, Salivary alterations, Dysgeusia, Infections, Bleeding tendency, Osteonecrosis of the jaws due to bisphosphonates).
Conclusion In order to minimize morbidity in the head and neck cancer patients, it is recommended for consulting to dental health care providers before, during and after cancer therapy.
- Chemotherapy
- Radiotherapy
- Management
- Head and neck neoplasm
How to Cite
References
H Horney DJ, Smith HE, McGurk M, Weinman J, Herold J, Altman K, et al. Associations between quality of life, coping styles, optimism, and anxiety and depression in pretreatment patients with head and neck cancer. Head Neck. 2011 Jan;33(1):65-71.
Argiris A, Karamouzis MV, Raben D, Ferris RL. Head and neck cancer. Lancet. 2008 May;371(9625):1695-709.
Tanaka TI, Chan HL, Tindle DI, MacEachern M, Oh TJ. Updated clinical considerations for dental implant therapy in irradiated head and neck cancer patients. J Prosthodont. 2013 Nov;22(6):432-8.
Bulacio L, Paz M, Ramadán S, Ramos L, Pairoba C, Sortino M, et al. Oral infections caused by yeasts in patients with head and neck cancer undergoing radiotherapy. Identification of the yeasts and evaluation of their antifungal susceptibility. J Mycol Med. 2012 Dec;22(4):348-53..
Van der Molen L, van Rossum MA, Burkhead LM, Smeele LE, Hilgers FJ. Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review. Eur Arch Otorhinolaryngol. 2009 Jun;266(6):889-900.
Tezal M, Scannapieco FA, Wactawski-Wende J, Meurman JH, Marshall JR, Rojas IG, et al. Dental caries and head and neck cancers. JAMA Otolaryngol Head Neck Surg. 2013 Oct;139(10):1054-60.
Tezal M, Sullivan MA, Hyland A, Marshall JR, Stoler D, Reid ME, et al. Chronic periodontitis and the incidence of head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2406-12.
Hong CH, Napeñas JJ, Hodgson BD, Stokman MA, Mathers-Stauffer V, Elting LS, et al. A systematic review of dental disease in patients undergoing cancer therapy. Support Care Cancer. 2010 Aug;18(8):1007-21.
Beech N, Robinson S, Porceddu S, Batstone M. Dental management of patients irradiated for head and neck cancer. Aust Dent J. 2014 Mar;59(1):20-8.
Shah JP, Gil Z. Current concepts in management of oral cancer–surgery. Oral Oncol. 2009 Apr-May;45(4-5):394-401.
Schwartz DL, Garden AS, Thomas J, Chen Y, Zhang Y, Lewin J, et al. Adaptive radiotherapy for head-and-neck cancer: initial clinical outcomes from a prospective trial. Int J Radiat Oncol Biol Phys. 2012 Jul;83(3):986-93.
Dirix P, Nuyts S. Evidence-based organ-sparing radiotherapy in head and neck cancer. Lancet Oncol. 2010 Jan;11(1):85-91.
Surucu M, Shah KK, Roeske JC, Choi M, Small W and Emami B, Adaptive Radiotherapy for Head and Neck Cancer. Technol Cancer Res Treat. 2017 Apr; 16(2): 218–223.
Rosenthal DI, Trotti A, editors. Strategies for managing radiation-induced mucositis in head and neck cancer. Seminars in radiation oncology; 2009: Semin Radiat Oncol. 2009 Jan;19(1):29-34.
Russo G, Haddad R, Posner M, Machtay M. Radiation treatment breaks and ulcerative mucositis in head and neck cancer. Oncologist. 2008;13(8):886-98.
Rapidis AD, Dijkstra P, Roodenburg J, Rodrigo J, Rinaldo A, Strojan P, et al. Trismus in patients with head and neck cancer: etiopathogenesis, diagnosis and management. Clin Otolaryngol. 2015 Dec;40(6):516-26.
Rivero JA, Shamji O, Kolokythas A. Osteoradionecrosis: a review of pathophysiology, prevention and pharmacologic management using pentoxifylline, alpha-tocopherol, and clodronate. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Nov;124(5):464-471.
Vissink A, Mitchell JB, Baum BJ, Limesand KH, Jensen SB, Fox PC, et al. Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers. Int J Radiat Oncol Biol Phys. 2010 Nov;78(4):983-91.
Little M, Schipper M, Feng FY, Vineberg K, Cornwall C, Murdoch-Kinch C-A, et al. Reducing xerostomia after chemo-IMRT for head-and-neck cancer: beyond sparing the parotid glands. Int J Radiat Oncol Biol Phys. 2012 Jul;83(3):1007-14.
Hegarty A, Hodgson T. Management of xerostomia and salivary hypofunction. Prog Palliat Care. 2008 Feb;16(1):21-30.
Marur S, D'Souza G, Westra WH, Forastiere AA. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol. 2010 Aug;11(8):781-9.
Lalla RV, Latortue MC, Hong CH, Ariyawardana A, D’Amato-Palumbo S, Fischer DJ, et al. A systematic review of oral fungal infections in patients receiving cancer therapy. Support Care Cancer. 2010 Aug;18(8):985-92.
Chung CH, Gillison ML. Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications. Clin Cancer Res. 2009 Nov 15;15(22):6758-62.
Tolentino EdS, Centurion BS, Ferreira LHC, Souza APd, Damante JH, Rubira-Bullen IRF. Oral adverse effects of head and neck radiotherapy: literature review and suggestion of a clinical oral care guideline for irradiated patients. J Appl Oral Sci. 2011 Oct;19(5):448-54.
Roopashri G, Jayanthi K, Guruprasad R. Efficacy of benzydamine hydrochloride, chlorhexidine, and povidone iodine in the treatment of oral mucositis among patients undergoing radiotherapy in head and neck malignancies: A drug trail. Contemp Clin Dent. 2011 Jan;2(1):8-12.
Goldstein NE, Genden E, Morrison RS. Palliative care for patients with head and neck cancer: "I would like a quick return to a normal lifestyle". JAMA. 2008 Apr ;299(15):1818-25.
Leenstra JL, Miller RC, Qin R, Martenson JA, Dornfeld KJ, Bearden JD, et al. Doxepin rinse versus placebo in the treatment of acute oral mucositis pain in patients receiving head and neck radiotherapy with or without chemotherapy: a phase III, randomized, double-blind trial (NCCTG-N09C6 [Alliance]). J Clin Oncol 2014 May;32(15):1571-7.
Kazemian A, Kamian S, Aghili M, Hashemi F, Haddad P. Benzydamine for prophylaxis of radiation‐induced oral mucositis in head and neck cancers: a double‐blind placebo‐controlled randomized clinical trial. Eur J Cancer Care (Engl) 2009 Mar;18(2):174-8.
Saunders DP, Epstein JB, Elad S, Allemano J, Bossi P, Van De Wetering MD, et al. Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients. Support Care Cancer 2013 Nov;21(11):3191-207.
Gomez DR, Estilo CL, Wolden SL, Zelefsky MJ, Kraus DH, Wong RJ, et al. Correlation of osteoradionecrosis and dental events with dosimetric parameters in intensity-modulated radiation therapy for head-and-neck cancer. Int J Radiat Oncol Biol Phys 2011 Nov;81(4):e207-e13.
Schoenfeld GO, Amdur RJ, Morris CG, Li JG, Hinerman RW, Mendenhall WM. Patterns of failure and toxicity after intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys 2008 Jun;71(2):377-85.
Spiegelberg L, Djasim UM, van Neck HW, Wolvius EB, van der Wal KG. Hyperbaric oxygen therapy in the management of radiation-induced injury in the head and neck region: a review of the literature. J Oral Maxillofac Surg 2010 Aug;68(8):1732-9.
Murphy BA, Beaumont JL, Isitt J, Garden AS, Gwede CK, Trotti AM, et al. Mucositis-related morbidity and resource utilization in head and neck cancer patients receiving radiation therapy with or without chemotherapy. J Pain Symptom Manage 2009 Oct;38(4):522-32.
Abdulrhman M, Elbarbary NS, Ahmed Amin D, Saeid Ebrahim R. Honey and a mixture of honey, beeswax, and olive oil–propolis extract in treatment of chemotherapy-induced oral mucositis: a randomized controlled pilot study. Pediatr Hematol Oncol 2012 Apr;29(3):285-92.
Saito H, Watanabe Y, Sato K, Ikawa H, Yoshida Y, Katakura A, et al. Effects of professional oral health care on reducing the risk of chemotherapy-induced oral mucositis. Support Care Cancer 2014 Nov;22(11):2935-40.
Peterson DE, Öhrn K, Bowen J, Fliedner M, Lees J, Loprinzi C, et al. Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy. Support Care Cancer 2013 Jan;21(1):327-32.
Harris DJ, Eilers J, Harriman A, Cashavelly BJ, Maxwell C. Putting evidence into practice®: Evidence-based interventions for the management of oral mucositis. Clin J Oncol Nurs 2008 Feb;12(1):141-52.
Vadhan-Raj S, Trent J, Patel S, Zhou X, Johnson MM, Araujo D, et al. Single-dose palifermin prevents severe oral mucositis during multicycle chemotherapy in patients with cancer: a randomized trial. Ann Intern Med. 2010 Sep;153(6):358-67.
Raber-Durlacher JE, Von Bültzingslöwen I, Logan RM, Bowen J, Al-Azri AR, Everaus H, et al. Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients. Support Care Cancer 2013 Jan;21(1):343-55.
Bjordal JM, Bensadoun R-J, Tunèr J, Frigo L, Gjerde K, Lopes-Martins RA. A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis. Support Care Cancer 2011 Aug;19(8):1069-77.
Chaveli-López B. Oral toxicity produced by chemotherapy: A systematic review. J Clin Exp Dent. 2014 Feb;6(1):e81-90.
Remesh A. Toxicities of anticancer drugs and its management. Int J Basic Clin Pharmacol. 2017;1(1):2-12.
Kaste SC, Goodman P, Leisenring W, Stovall M, Hayashi R, Yeazel M, etal . Impact of Radiation and Chemotherapy on Risk of Dental Abnormalities: A Report from the Childhood Cancer Survivor Study. Cancer 2009 Dec; 115(24): 5817–5827.
Meurman JH, Grönroos L. Oral and dental health care of oral cancer patients: hyposalivation, caries and infections. Oral oncol. 2010 Jun;46(6):464-7.
Kautio A-L, Haanpää M, Kautiainen H, Kalso E, Saarto T. Burden of chemotherapy-induced neuropathy—a cross-sectional study. Support Care Cancer 2011 Dec;19(12):1991-6.
Dowling P, Wormald R, Meleady P, Henry M, Curran A, Clynes M. Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis. J Proteomics 2008 Jul;71(2):168-75.
Ackerman D, Laszlo M, Provisor A, Yu A. Nutrition Management for the Head and Neck Cancer Patient. Cancer Treat. Res. 2018;174:187-208.
Sapir E, Tao Y, Feng F, Samuels S, El Naqa I, Murdoch-Kinch CA, et al. Predictors of Dysgeusia in Patients With Oropharyngeal Cancer Treated With Chemotherapy and Intensity Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys 2016 Oct;96(2):354-61.
Xiao C, Beitler JJ, Higgins KA, Glazer T, Huynh LK, Paul S, et al. Associations among human papillomavirus, inflammation, and fatigue in patients with head and neck cancer. Cancer 2018 Aug;124(15):3163-3170.
Tham T, Rahman L, Persaud C, Olson C, Costantino P. Venous Thromboembolism Risk in Head and Neck Cancer: Significance of the Preoperative Platelet-to-Lymphocyte Ratio. Otolaryngol Head Neck Surg 2018 Jul;159(1):85-91.
Buddula A, Assad DA, Salinas TJ, Garces YI. Survival of dental implants in native and grafted bone in irradiated head and neck cancer patients: a retrospective analysis. Indian J Dent Res 2011 Sep-Oct;22(5):644-8.
Danielsson D, Brehwens K, Halle M, Marczyk M, Sollazzo A, Polanska J, et al. Influence of genetic background and oxidative stress response on risk of mandibular osteoradionecrosis after radiotherapy of head and neck cancer. Head Neck 2016 Mar;38(3):387-93.
O'Dell K, Sinha U. Osteoradionecrosis. Oral Maxillofac Surg Clin North Am 2011 Aug;23(3):455-64.
Strojan P, Hutcheson KA, Eisbruch A, Beitler JJ, Langendijk JA, Lee AWM, et al. Treatment of late sequelae after radiotherapy for head and neck cancer. Cancer Treat Rev 2017 Sep;59:79-92.
Aggarwal K, Goutam M, Singh M, Kharat N, Singh V, Vyas S, et al. Prophylactic Use of Pentoxifylline and Tocopherol in Patients Undergoing Dental Extractions Following Radiotherapy for Head and Neck Cancer. Niger J Surg 2017 Jul-Dec;23(2):130-3.
- Abstract Viewed: 200 times
- PDF Downloaded: 112 times