Post-operative effects of Oral Midazolam versus Hydroxyzine on Ketamine Intravenously Sedated children
Journal of Dental School, Shahid Beheshti University of Medical Sciences,
Vol. 36 No. 3 (2018),
3 March 2019
,
Page 91-94
https://doi.org/10.22037/jds.v36i3.24540
Abstract
Objectives The aim of this clinical trial was to compare the effects of oral Midazolam with oral Hydroxyzine on post sedation using IV Ketaminein children.
Methods This single blind cross over clinical trial, was conducted on 25 children aged 2-6 years of ASA I and definitely negative by Frankl behavioral scale. Participants were divided into two groups: Group I received hydroxyzine syrup premed at the first session and midazolam oral at the 2nd visit. Group II received the premed in the opposite order. Vital signs, were recorded sedation depth, recovery and discharge status and compared potential adverse effects of sedative drugs were checked and recorded including sleepiness, nausea and vomiting, vertigo at 1stand 6th hours of discharge. Collected data were analyzed using SPSS V 20 using Repeated Measures ANOVA and Mann-Whitney tests.
Results No significant differences were noticeable between two groups when vital signs, were compared in addition to response to drugs, working time, sleepiness, nausea and vomiting rates. However, there was a significant difference between groups in the incidence of vertigo one hour post operatively with higher prevalence in the Hydroxyzine group. (P=0.022)
Conclusion Under the circumstances of this study, no significant difference was found between the two regimen groups, but vertigo was appeared as being higher after the first hour in the Hydroxyzine group.
- Premedication
- Midazolam
- Hydroxyzine
- Sedation
- Pediatric dentistry
How to Cite
References
Matharu LL, Ashley PF. What is the evidence for paediatric dental sedation? J Dent 2007 Jan;35(1): 2-20.
Piedalue RJ, Milnes A. Nonpharmacological techniques help practitioners manage young patients. J Mass Dent Soc 1994 Winter;43(1):231-5, 247-51.
Lloyd CJ, Alredy T, Lowry JC. Intranasal midazolam as an alternative to general anesthesia management of children with oral and maxillofacial trauma. Br J Oral Maxillofac Surg 2000 Dec;38(6):593-95.
Cathers J W, Wilson CFG, Webb MD, Alvarez MED, Schiffman T, Taylor S. A Comparison of Two Meperidine/Hydroxyzine Sedation Regimensfor the Uncooperative Pediatric Dental Patient.Pediatr Dent 2005Sep-Oct;27(5): 395-400.
Al Taher W MA, Mansour EE, El Shafei MN. Comparative study between novel sedative drug (dexmedetomidine) versus midazolam–propofol for conscious sedation in pediatric patients undergoing oro-dental procedures. Egyptian J Anaesth 2010;26: 299–304.
Sams DR, Cook EW, Jackson JG, Roebuck BL. Behavioral assessments of two drug combinations for oral sedation. Pediatr Dent.1993 May-June;15 (3): 186-90.
Dean JA, Avery DR, McDonald RE. Dentistry for the child and adolescent 9th ed. Maryland Heights, Missouri: Mosbey Elsevier co; 2011.
Malamed SF. Sedation a guide to patient management. 5th ed. St Luise: Mosby Elsevier, 2010.
Azevedo ID, Fernandes Ferreira M A, Serejo da Costa AP, Bosco VL, Moritz RD. Efficacy and Safety of Midazolam for Sedation in Pediatric Dentistry: A Controlled Clinical Trial. J Dent Child (Chic) 2013 Sep-Dec;80(3):133-8.
Estelle F, Simons R. Advances in H1-Antihistamines. N Engl J Med 2004Nov; 351(21): 2203-2217.
Shapira J, Kupietzky A, Kadari A, Fuks A B, Holan G. Comparison of Oral Midazolam With and Without Hydroxyzine in the Sedation of Pediatric Dental Patients. Pediatr Dent 2004Nov-Dec;26(6): 492-96.
Davidovich E, Naser S, Shapira J, Ram D. Premedication Intake Behavior- Does It Predict Behavior During Dental Treatment? J Clinical PediatrDent 2012Summer;36(4): 389-92.
King DL, Berlocher WC. Premedication in Pedodontics Attitudes and Agents.Pediatr. Dent. 1979Mar-Apr;1(4): 251-57.
Abdallah C, Hannallah R. Premedication of the Child Undergoing Surgery. Middle East J Anaesthesiol 2011Jun;21(2):165-74.
Alzahrani AM, Wyne AH. Use of Oral Midazolam Sedation in Pediatric Dentistry: A Review. Pakistan Oral Dent J 2012Dec; 32(3): 444-55.
Sahoo S, Kaur M, Tripathy HK, Kumar A, Kohli S, Nanda S. Comparative evaluation of midazolam and clonidine as pediatric oral premedication. Anesthesia: Essays Res 2013May-Aug;7(2): 221-27.
Papineni A, Lourenco-Matharu L, Ashley PF. Safety of oral midazolam sedation use in paediatric dentistry: a review. Int J Pediatr Dent 2012Jan;24(1): 2-13.
Chaudhary S, Jindal R, Girotra G, Salhotra R, Rautela S R, Sethi A K. Is midazolam superior to triclofos and hydroxyzine as premedicant in children.JAnaesthesiolClinPharmacol 2014 Jan;30(1):53-8.
Ritwik P, Cao L T, Curran R, Musselman R J. Post-sedation Events in Children Sedated for Dental Care. AnesthProg 2013Summer;60(2): 54–9.
Yasny JS, Asgari A. Considerations for the Use of Enteral Sedation in Pediatric Dentistry. J ClinPediatr Dent. 2007Winter;32(2): 85–94.
Dallman J A, IgnelziJr M A, Briskie DM. Comparing the safety, efficacy and recovery of intranasal midazolam vs. oral chloral hydrate and promethazine. Pediatr Dent 2001Sep-Oct;23(5): 424-30.
Songarj P, VisalyaputraSh, Therasakvichya S et al. Hydroxyzine for the Prevention of Pruritus and Nausea Vomiting from Spinal Morphine in Patients Having Transabdominal Hysterectomy under Combined Spinal-General Anesthesia: A randomized control trial. Siriraj Med J. 2010July-Aug;62(4): 165-169.
Martinez D, Wilson S. Children Sedated For Dental Care: A Pilot Study of the 24-hour Postsedation Period. Pediatr Dent. 2006May-Jun;28(3): 260-64.
FallahinejadGhajari M, VahidGolpayegani M, Bargrizan M, Ansari G,Shayeghi S. Sedative Effect of Oral Midazolam/Hydroxyzine versus Chloral Hydrate/Hydroxyzine on 2-6 Year-Old Uncooperative Dental Patients: A Randomized Clinical Trial. J Dent 2014Jan;11(1): 93-99.
Robb ND. Which is the most effective drug or method of sedation used for anxious children. What are the most effective techniques for the use of conscious sedation behavior management in paediatric dentistry? Evid Based Dent 2005;6(3): 71.
- Abstract Viewed: 142 times
- PDF Downloaded: 105 times