The effect of Atorvastatin and Endurance training and their Combination on Testosterone Levels, Leydig, Spermatogonia, Spermatocyte cells numbers, Diameter and Thickness of Seminiferous Tubules and testicular morphology in rats
International Pharmacy Acta,
Vol. 6 No. 1 (2023),
1 January 2023
,
Page e5: 1-8
https://doi.org/10.22037/ipa.v6i1.40193
Abstract
Many drugs and regular exercise may have effect on male fertility. Therefore in the present study we investigated the effect of Atorvastatin and Endurance training on serum levels of testosterone,Leydig ,spermatogonia, Spermatocyte cells numbers and testicular morphology and morphometric evaluation in rats. 30Wistar rats(230±10g)were randomly divided into 6 groups:control, endurance training,atorvastatin(5 mg/kg and 10 mg/kg),the endurance training + atorvastatin (5 mg/kg and 10 mg/kg),5 rats per group. Drug intervention groups received atorvastatin for 4 weeks using gavage.Training groups also run a rodent treadmill 5 days a week for 4 weeks(speed of 10 m/min for 10 min in first week and other week: 16 m/min for 50 min) Serum testosterone level was measured by ELISA Kit.The results showed in the endurance training+atorvastatin 10 mg/kg, morphological disruption of testicular was observed.The number of Leydig, spermatogonia and Spermatocyte as well as blood testosterone level and germinal epithelium thickness were significantly decreased in the endurance training+atorvastatin 10 mg/kg compared to the control group(p< 0.05). In conclusion,the results of this study showed the negative effect of the combination of endurance training and high dose atorvastatin (10 mg/kg ) on testicular tissue and male reproductive system due to decreased levels of testosterone in rats.
- Endurance Training
- Atorvastatin
- Testosterone
- Leydig
- Spermatogonia
- Spermatocyte
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References
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