Use of Zeolive (Composition with Zeolites Base) as an Adjunct in the Treatment of Acetaminophen Overdose Zeolive as an Adjunct in the Treatment of Acetaminophen Overdose
International Pharmacy Acta,
Vol. 5 No. 1 (2022),
19 June 2022
One of the most important of zeolite's applications is the detoxification of toxic substances. This study was planned to evaluate the effect of Zeolive on acetaminophen toxicity. This was a single-blind clinical trial study. The participating population was patients with acetaminophen poisoning in Loghman Hakim Hospital from December 2021 to March 2022. Patients were randomly divided into two groups of 30 patients. The control group was given routine treatments and the intervention group was given 1000 mg of Zeolive per day for 2 weeks in addition to routine treatments. Levels of AST, ALT, ALP and PT were measured before and after the intervention. Data were analyzed by SPSS software.
The mean age was 28.3 ±7.6 in the intervention group and 25.9 ±6.8 years in the control group. The observed decrease in PT and activities of AST, ALT, and ALP after the intervention was not statistically significant with the control group. Statistical analysis of the difference values before and after the intervention for liver enzymes and PT showed no significant difference between the two groups
Zeolive, as an absorbent powder, may not affect the amount of enzymes and blood factors. Further studies and consideration of other factors are recommended.
- clinical trials
- liver enzymes
How to Cite
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