Hepatoprotective Properties of Starflowers from an Annual Herb, Borago officinalis L. (Boraginaceae) Hepatoprotective profile of Borage
International Pharmacy Acta,
Vol. 5 No. 1 (2022),
19 June 2022
,
Page e7: 1-7
https://doi.org/10.22037/ipa.v5i1.38060
Abstract
Traditionally, the decoction of leaves, flowers and stems of Borago officinalis was widely used in the treatment of liver diseases. The present work is aimed to assess the hepatoprotective properties of selected ethanolic fractions of Borago officinalis flowers in D-galactosamine (GalN)-induced oxidative stress in rats. In vitro antioxidant activities were assessed through superoxide radical and ferric ion assays, while hepatoprotective effects were evaluated by GalN-induced oxidative stress in rats. Initially, ethanolic extract of B. officinalis flowers was fractionated using column chromatography. The preliminary antioxidant screening of these fractions identified two main bioactive fractions (BoF2 and BoF5), which were found to have significant radical scavenging properties compared to ascorbic acid. Based on the antioxidant profile, BoF2 and BoF5 were evaluated for hepatoprotective activity in GalN-induced rats. The Wistar rats were grouped (n = 6) and treated with BoF2 and BoF5 (100 and 200 mg/kg), silymarin (25 mg/kg) orally for 7 days, and GalN (200 mg/kg, i.p) was dosed on day 5. this study found that chronic administration of GalN significantly (P < 0.0001) altered the liver parameters and oxidative stress markers (MDA, SOD, and CAT). The administration of BoF5 prominently ameliorated the oxidative stress induced by GalN compared to BoF2. Histopathological studies further supported the significant hepatoprotective action of BoF5. The present study demonstrates that the B. officinalis possess significant antioxidant properties by augmenting the magnitude of the antioxidant enzymes (SOD and CAT), and further reducing MDA levels.
- Antioxidant
- GalN-induced
- Hepatoprotective
- Oxidative stress
- Borago officinalis
- liver parameters
How to Cite
References
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