Homometallic Dinuclear Cu(II) and Zn(II) Complexes Derived from Salophen-type Ligand: Synthesis, Characterization and Anticancer Screening
International Pharmacy Acta,
Vol. 3 No. 1 (2020),
14 December 2020
,
Page 3e5:1-6
https://doi.org/10.22037/ipa.v3i1.31911
Abstract
Introduction:
A series of salophen-type Cu(II) and Zn(II) dinuclear metal complexes of a Schiff base derived from o-phenylenediamine were successfully synthesized, characterized and screened for their anticancer activity.
Methods and Results:
All compounds were characterized physicochemical and spectral techniques namely elemental analysis (C, H, N), magnetic susceptibility (MSB), molar conductivity, thermal gravimetric analysis (TGA), infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy. The shifting of C=N, C-O phenolic and C-O methoxy peaks and the appearance of new peaks assignable to M-N and M-O in IR spectra of the complexes indicated the coordination of azomethine N, phenolic O and methoxy O donor atoms with metal centers. The disappearance of the hydroxyl peak in 1H NMR spectra of the Zn(II) complex supported the involvement of phenolic O upon formation of the metal complex. The Cu(II) complex was paramagnetic with magnetic moment values of 1.97, close to the theoretical spin only magnetic moment, μso, for Cu(II). The compounds were screened for anticancer activity against human colon cancer cells (HCT116). The Cu(II) complex revealed the highest activity with IC50 value of 21.17 ± 0.76 μM.
Conclusion:
The ligand coordinated as a hexadentate ligand through O and N donor atoms of phenolic, methoxy and azomethine groups. From anticancer screening, it was observed that Cu2(OVanOPD) complex exhibited the highest activity followed by OVanOPD ligand and Zn2(OVanOPD) complex.
- Schiff base
- homometallic dinuclear
- polydentate ligand
- colon cancer
How to Cite
References
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