A Systematic Review of Preclinical and Clinical Studies on Therapeutic Potential of Piper nigrum on Cognitive Impairment in Alzheimer's Disease and other Biological Conditions of Memory Loss Piper Nigrum effects on cognitive impairment and alzheimer
International Pharmacy Acta,
Vol. 5 No. 1 (2022),
19 June 2022
,
Page e3:1-14
https://doi.org/10.22037/ipa.v5i1.29046
Abstract
Piper nigrum is one of the most familiar spices due to its’ pharmacological and physiological properties. Piperine is a main active alkaloid of Piper nigrum with a broad spectrum of biological activities including anti-aging, anti-inflammatory, anti-cancer, anti-depressant, and cognition enhancer, thus it is effective in correlated diseases. Principally, the useful effects of piperine in neurological conditions have been confirmed in in-vitro and in-vivo studies. Beta-caryophyllene a major constituent of its essential oils well known for neuroprotective and specially nootropic effects. Some clinical trials have reported that Piper nigrum possesses preventive and therapeutic effects in memory loss related disorders.
The current systematic review aimed to consider the effects of Piper nigrum on cognition and memory performance as well as Alzheimer’s disease. Electronic databases including Scopus, PubMed, Web of Science, ProQuest, and Embase were searched with the keywords “piper nigrum” OR piperine OR “black pepper” OR β-caryophyllene OR beta-caryophyllene AND “Alzheimer’s disease” OR dementia OR amnesia OR memory OR cognitive OR cognition OR nootropic until 18 January 2020. Only in-vivo and clinical studies with sufficient data were included in this review.
The results of this systematic review showed that Piper nigrum may have significant effects on memory and cognitive performance assessed by related tests though more randomized clinical trials are needed to validate its’ indication in cognitive impairments.
- Piper nigrum; piperine
- beta-caryophyllene
- Alzheimer’s disease
- Dementia; Cognition
How to Cite
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