The Effect of Resveratrol on Anxiolytic and Emotional Memory Impairment Induced by Morphine
Archives of Advances in Biosciences,
Vol. 13 No. 1 (2022),
1 January 2022
,
Page 1-7
https://doi.org/10.22037/aab.v13i2.38258
Abstract
Introduction: A body of pharmacological and non-pharmacological studies have been conducted with the purpose of attenuating morphine side effects such as anxiety and memory impairment. It seems that there is a close relationship between resveratrol and morphine according to molecular cell pathway. Thus, the aim of the present investigation was to evaluate the effect of resveratrol on anxiolytic-like behavior and emotional memory induced by morphine.
Materials and Methods: A basic experimental research has been designed for this study. The test-retest protocol of elevated plus-maze (EPM) apparatus was used. The male Wistar rat received subthreshold dose of resveratrol (50 mg/kg), 15 minutes before injection of saline (1 ml/kg) or different doses of morphine (1.25, 2.5 and 5 mg/kg) on the test day. Twenty-four hours after test day, the EPM’s parameters was also measured without drug injection. All drugs were injected intraperitonealy.
Results: The data indicated that higher dose of morphine (5 mg/kg) elevated Open Arm Time (%OAT, P<.05) and Open Arm Enters (%OAE, P<.001) on the test day, and also %OAT (P<.05) and %OAE (P<.001) on the retest day, indicating decrease of anxiety and impairment of emotional memory, respectively. Moreover, subthreshold dose of resveratrol (50 mg/kg) restored all parameters induced by higher doses of morphine in the test (P<.05 for %OAT and P<.01 for %OAE) and the retest day (P<.05 for %OAT and P<.001 for %OAE).
Conclusion: The principal findings of this research showed that resveratrol can alter morphine responses on anxiety and emotional memory process. It is also postulated that the resveratrol can decrease the morphine side effects in the people using it.
- Anxiety, Memory, Morphine, Resveratrol, Rat
How to Cite
References
] Moradinazar M, Najafi F, Jalilian F, Pasdar Y, Hamzeh B, Shakiba E, et al. Prevalence of drug use, alcohol consumption, cigarette smoking and measure of socioeconomic-related inequalities of drug use among Iranian people: findings from a national survey. Subst Abuse Treat Prev Policy. 2020; 15(1):1-11. [DOI:10.1186/s13011-020-00279-1] [PMID] [PMCID]
Soroosh D, Neamatshahi M, Zarmehri B, Nakhaee S, and Mehrpour O. Drug-induced prolonged corrected QT interval in patients with methadone and opium overdose. Subst Abuse Treat Prev Policy. 2019; 14(1):1-5. [DOI:10.1186/s13011-019-0196-3] [PMID] [PMCID]
Malboosi N, Nasehi M, Hashemi M, Vaseghi S, Zarrindast MR. The neuroprotective effect of NeuroAid on morphine-induced amnesia with respect to the expression of TFAM, PGC-1alpha, DeltafosB and CART genes in the hippocampus of male Wistar rats. Gene. 2020; 742:144601. [DOI:10.1016/j.gene.2020.144601] [PMID]
Nasehi M, Nasehi M, Rahmani-Nia F, Mirzaei B, Torabi-Nami M, Zarrindast MR. Swimming improves the emotional memory deficit by scopolamine via mu opioid receptors. Physiol Behav. 2014; 128:237-46. [DOI:10.1016/j.physbeh.2014.02.011] [PMID]
Valizadegan F, Oryan S, Nasehi M, Zarrindast MR. Interaction between morphine and noradrenergic system of basolateral amygdala on anxiety and memory in the elevated plus-maze test based on a test-retest paradigm. Arch Iran Med. 2013; 16(5):281-7. [PMID]
Anvari SS, Nasehi M, Zarrindast MR. Effects of acute and subchronic anodal transcranial direct current stimulation (tDCS) on morphine-induced responses in hotplate apparatus. Galen Med J. 2019; 8:1-7. [DOI:10.31661/gmj.v8i0.1157] [PMID] [PMCID]
Eslimi D, Oryan S, Nasehi M, Zarrindast MR. Effects of opioidergic systems upon anxiolytic-like behaviors induced in cholestatic rats. Eur J Pharmacol. 2011; 670(1):180-5. [DOI:10.1016/j.ejphar.2011.08.024] [PMID]
Elhampour L, Azarbayjani MA, Nasehi M, Peeri M. Concurrent effects of exercise and curcumin on spatial learning and memory in sensitized male mice following morphine administration. Galen Med J. 2019; 8:e1072. [DOI:10.31661/gmj.v8i0.1072] [PMID] [PMCID]
Heshmatzad K, Nasehi M, Vaseghi S. Effects of morphine and NeuroAid on the expression levels of GluN2A and GluN3A in the hippocampus and striatum of rats. Iran J Basic Med Sci. 2021; 24(4):469-75. [DOI:10.22038/ ijbms.2021.52004.11787] [PMID]
Perez-Severiano F, Bermudez-Ocana DY, Lopez-Sanchez P, Rios C, Granados-Soto V. Spinal nerve ligation reduces nitric oxide synthase activity and expression: effect of resveratrol. Pharmacol Biochem Behav. 2008; 90(4):742-7. [DOI:10.1016/j.pbb.2008.05.024] [PMID]
Kumar A, Kaundal RK, Iyer S, Sharma SS. Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy. Life Sci. 2007; 80(13):1236-44. [DOI:10.1016/j.lfs.2006.12.036] [PMID]
Tsai RY, Chou KY, Shen CH, Chien CC, Tsai WY, Huang YN, et al. Resveratrol regulates N-methyl-D-aspartate receptor expression and suppresses neuroinflammation in morphine-tolerant rats. Anesth Analg. 2012; 115(4):944-52. [DOI:10.1213/ANE.0b013e31825da0fb] [PMID]
Tsai RY, Wang JC, Chou KY, Wong CS, and Cherng CH. Resveratrol reverses morphine-induced neuroinflammation in morphine-tolerant rats by reversal HDAC1 expression. J Formos Med Assoc. 2016; 115(6):445-54. [DOI:10.1016/j.jfma.2015.05.010] [PMID]
He X, Ou P, Wu K, Huang C, Wang Y, Yu Z, et al. Resveratrol attenuates morphine antinociceptive tolerance via SIRT1 regulation in the rat spinal cord. Neurosci Lett. 2014; 566:55-60. [DOI:10.1016/j. neulet.2014.02.022] [PMID]
Chegini HR, Nasehi M, Zarrindast MR. Differential role of the basolateral amygdala 5-HT3 and 5-HT4 serotonin receptors upon ACPA-induced anxiolytic-like behaviors and emotional memory deficit in mice. Behav Brain Res. 2014; 261:114-26. [DOI:10.1016/j.bbr.2013.12.007] [PMID]
Khodayar E, Oryan S, Nasehi M, Zarrindast MR. Effect of nucleus accumbens shell 5-HT4 receptors on the impairment of ACPA-induced emotional memory consolidation in male Wistar rats. Behav Pharmacol. 2016; 27(1):12-21. [DOI:10.1097/FBP.0000000000000174] [PMID]
Bertoglio LJ, Joca SR, Guimaraes FS. Further evidence that anxiety and memory are regionally dissociated within the hippocampus. Behav Brain Res. 2006; 175(1):183-8. [DOI:10.1016/j.bbr.2006.08.021] [PMID]
File SE. The interplay of learning and anxiety in the elevated plus-maze. Behav Brain Res. 1993; 58(1-2):199-202. [DOI:10.1016/0166-4328(93)90103-w] [PMID]
Wall PM, Messier C. Concurrent modulation of anxiety and memory. Behav Brain Res. 2000; 109(2):229-41. [DOI:10.1016/s0166-4328(99)00177-1] [PMID]
Pellow S, Chopin P, File SE, Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods. 1985; 14(3):149-67. [DOI:10.1016/0165-0270(85)90031-7] [PMID]
Motevasseli T, Rezayof A, Zarrindast MR, Nayer-Nouri T. Role of ventral hippocampal NMDA receptors in anxiolytic-like effect of morphine. Physiol Behav. 2010; 101(5):608-13. [DOI:10.1016/j.physbeh.2010.09.013] [PMID]
Nejati S, Khakpai F, Zarrindast MR. Synergistic effect between citalopram and citicoline on anxiolytic effect in non-sensitized and morphine-sensitized mice: An isobologram analysis. Brain Res. 2020; 1734:146701. [DOI:10.1016/j.brainres.2020.146701] [PMID]
Rezayof A, Assadpour S, Alijanpour S. Morphine-induced anxiolytic-like effect in morphine-sensitized mice: involvement of ventral hippocampal nicotinic acetylcholine receptors. Pharmacol Biochem Behav. 2013; 103(3):460-6. [DOI:10.1016/j.pbb.2012.10.003] [PMID]
Bajic D, Commons KG, Soriano SG. Morphine-enhanced apoptosis in selective brain regions of neonatal rats. Int J Dev Neurosci. 2013; 31(4):258-66. [DOI:10.1016/j. ijdevneu.2013.02.009] [PMID]
Erbs E, Faget L, Ceredig RA, Matifas A, Vonesch JL, Kieffer BL, et al. Impact of chronic morphine on delta opioid receptor-expressing neurons in the mouse hippocampus. Neuroscience. 2016; 313:46-56. [DOI:10. 1016/j.neuroscience.2015.10.022]
Garcia-Carmona JA, Camejo DM, Almela P, Jimenez A, Milanes MV, Sevilla F, et al. CP-154,526 Modifies CREB Phosphorylation and Thioredoxin-1 Expression in the Dentate Gyrus following Morphine-Induced Conditioned Place Preference. PLoS One. 2015; 10(8):1-17. [DOI:10.1371/journal.pone.0136164] [PMID] [PMCID]
Gupta YK, Sharma M, Briyal S. Antinociceptive effect of trans-resveratrol in rats: Involvement of an opioidergic mechanism. Methods Find Exp Clin Pharmacol. 2004; 26(9):667-72. [DOI:10.1358/mf.2004.26.9.872563] [PMID]
Han Y, Jiang C, Tang J, Wang C, Wu P, Zhang G, et al. Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling. Eur J Pain. 2014; 18(10): 1458-70. [DOI:10.1002/ejp.511] [PMID]
Song H, Han Y, Pan C, Deng X, Dai W, Hu L, et al. Activation of adenosine monophosphate-activated protein kinase suppresses neuroinflammation and ameliorates bone cancer pain: involvement of inhibition on mitogen-activated protein kinase. Anesthesiology. 2015; 123(5):1170-85. [DOI:10.1097/ALN.0000000 000000856]
Granados-Soto V, Arguelles CF, Ortiz MI. The peripheral antinociceptive effect of resveratrol is associated with activation of potassium channels. Neuropharmacology. 2002; 43(5):917-23. [DOI:10.1016/s0028-3908(02)00130-2]
- Abstract Viewed: 179 times
- PDF Downloaded: 61 times
- MP3 Downloaded: 35 times