Anti-proliferative Effects Curcumin in Human Acute Lymphoblastic leukemia Cell Line
Archives of Advances in Biosciences,
Vol. 8 No. 2 (2017),
21 February 2017
,
Page 1-5
https://doi.org/10.22037/jps.v8i2.15685
Abstract
Acute lymphoblastic leukemia (ALL) is one of the most common cancers among children. Although there have been tremendous treatments, none of them have led to a precise cure. The use of herbal medicines which are safe and non-toxic have been demonstrated in this study. Curcumin is a polyphenol, hydrophobic product that is derived from turmeric plant. Curcumin has anti-toxic, anti-bacterial, anti-inflammatory, anti-cancer and anti-apoptosis properties. In recent years, extensive researches have been performed over the use of curcumin on cancers. In this study, CCRF-CEM cell line has been treated by curcumin. Rate of cytotoxicity of curcumin and the viability of the cells after treatment were evaluated by MTT assay and flow cytometry analysis. When different concentrations of curcumin were used upon the CCRF-CEM cell line at different times, it was found that curcumin effect depended on dose and time pattern. The results revealed that curcumin could induce apoptosis in CCRF-CEM cell line of acute lymphoblastic leukemia.
- Anticancer
- Curcumin
- Ischimia
- Human Acute Lymphoblastic leukemia
How to Cite
References
-Yallapu MM, Ebeling MC, Jaggi M, Chauhan SC. Plasma proteins interaction with curcumin nanoparticles: implications in cancer therapeutics. Current drug metabolism. 2013 May 1;14(4):504-15.
-Smith AJ, Oertle J, Prato D. Multiple actions of curcumin including anticancer, anti-inflammatory, antimicrobial and enhancement via cyclodextrin. Journal of Cancer Therapy. 2015 Feb 25;6(03):257.
-Inaba H, Greaves M, Mullighan CG. Acute lymphoblastic leukaemia. The Lancet. 2013 Jun 7;381(9881):1943-55.
-Talpaz M, Hehlmann R, Quintas-Cardama A, Mercer J, Cortes J. Re-emergence of interferon-α in the treatment of chronic myeloid leukemia. Leukemia. 2013 Apr 1;27(4):803-12.
-M Yallapu M, Jaggi M, C Chauhan S. Curcumin nanomedicine: a road to cancer therapeutics. Current pharmaceutical design. 2013 Apr 1;19(11):1994-2010.
- Wilken R, Veena MS, Wang MB, Srivatsan ES. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Molecular cancer. 2011 Feb 7;10(1):1.
- Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Molecular pharmaceutics. 2007 Nov 14;4(6):807-18.
- Shishodia S, Chaturvedi MM, Aggarwal BB. Role of curcumin in cancer therapy. Current problems in cancer. 2007 Aug 31;31(4):243-305.
- Cassileth BR, Deng G. Complementary and alternative therapies for cancer. The oncologist. 2004 Feb 1;9(1):80-9.
- Park W, Amin AR, Chen ZG, Shin DM. New perspectives of curcumin in cancer prevention. Cancer prevention research. 2013 May 1;6(5):387-400.
- Zhou H, S Beevers C, Huang S. The targets of curcumin. Current drug targets. 2011 Mar 1;12(3):332-47.
- M Yallapu M, Jaggi M, C Chauhan S. Curcumin nanomedicine: a road to cancer therapeutics. Current pharmaceutical design. 2013 Apr 1;19(11):1994-2010.
- Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?. The AAPS journal. 2009 Sep 1;11(3):495-510.
- Reuter S, Eifes S, Dicato M, Aggarwal BB, Diederich M. Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochemical pharmacology. 2008 Dec 1;76(11):1340-51.
-Zhou H, S Beevers C, Huang S. The targets of curcumin. Current drug targets. 2011 Mar 1;12(3):332-47.
-Xia Y, Jin L, Zhang B, Xue H, Li Q, Xu Y. The potentiation of curcumin on insulin-like growth factor-1 action in MCF-7 human breast carcinoma cells. Life sciences. 2007 May 16;80(23):2161-9.
-Saraswathy M, Gong S. Different strategies to overcome multidrug resistance in cancer. Biotechnology advances. 2013 Dec 31;31(8):1397-407.
- Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?. The AAPS journal. 2009 Sep 1;11(3):495-510.
- Kakarala M, Brenner DE, Korkaya H, Cheng C, Tazi K, Ginestier C, Liu S, Dontu G, Wicha MS. Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast cancer research and treatment. 2010 Aug 1;122(3):777-85.
- Klonisch, T., Wiechec, E., Hombach-Klonisch, S., Ande, S.R., Wesselborg, S., Schulze-Osthoff, K. and Los, M. (2008) Cancer Stem Cell Markers in Common Cancers: Therapeutic Implications. Trends in Molecular Medicine, 14, 450-460.
- Shehzad, A. and Lee, Y.S. (2010) Curcumin: Multiple Molecular Targets Mediate Multiple Pharmacological Actions: A Review. Drugs of the Future, 35, 113-119.
- Anand, P., Sundaram, C., Jhurani, S., Kunnumakkara, A.B. and Aggarwal, B.B. (2008) Curcumin and Cancer: An “Old-Age” Disease with an “Age-Old” Solution. Cancer Letters, 267, 133-164.
- He, Z.Y., Shi, C.B., Wen, H., Li, F.L., Wang, B.L. and Wang, J. (2011) Upregulation of p53 Expression in Patients with Colorectal Cancer by Administration of Curcumin. Cancer Investigation, 29, 208-213.
- Aggarwal BB. Prostate cancer and curcumin: add spice to your life. Cancer biology & therapy. 2008 Sep 1;7(9):1436-40.
- Dorai, T., Cao, Y.C., Dorai, B., Buttyan, R. and Katz, A.E. (2001) Therapeutic Potential of Curcumin in Human Prostate Cancer. III. Curcumin Inhibits Proliferation, Induces Apoptosis, and Inhibits Angiogenesis of LNCaP Prostate Cancer Cells in vivo. Prostate, 47, 293-303.
-Watson, J.L., Greenshields, A., Hill, R., Hilchie, A., Lee, P.W., Giacomantonio, C.A. and Hoskin, D.W. (2010) Curcumin-Induced Apoptosis in Ovarian Carcinoma Cells Is p53-Independent and Involves p38 Mitogen-Activated Protein Kinase Activation and Downregulation of Bcl-2 and Survivin Expression and Akt Signaling. Molecular Carcinogenesis, 49, 13-24.
- Abstract Viewed: 551 times
- PDF Downloaded: 192 times