The Trends in Peptide and Protein Sciences (Trends Pept. Protein Sci.) is a peer-reviewed, online-only (previously print-online), scientific journal owned by Protein Technology Research Center, Shahid Beheshti University of Medical Sciences and publish the documents in all important aspects of the research in peptides and proteins focusing on analytics and impurities, bioinformatics, biopharmaceuticals and vaccines, biotechnology, chemical synthesis, conformational analysis, design and  development of protein therapeutics, determination of structure, enzymology, folding and sequencing,  formulation and stability, function, genetics,  immunology, kinetics, modeling, molecular biology, pharmacokinetics and pharmacodynamics of therapeutic proteins and antibodies, pharmacology,  protein engineering and development, protein-protein interaction, proteomics, purification/expression/production, simulation, thermodynamics and  hydrodynamics and protein biomarkers. The aim of this Journal is to publish high quality original research articles, reviews, short communications and letters and to provide a medium for scientists and researchers to share their findings from the area of peptides and proteins. The Trends in Peptide and Protein Sciences is published in collaboration with Iranian Association of Pharmaceutical Scientists.

The Trends in Peptide and Protein Sciences has been granted the Scientific-Research Rank  by the Commission of Medical Sciences Journals of Ministry of Health, Treatment and Medical Education of I.R. Iran.

From volume 3 (2018) of TPPS, articles are continuously published online only, as soon as the review process is completed.

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Journal Info

Publisher:

Protein Technology Research Center, Shahid Beheshti University of Medical Sciences

Journal Name:

Trends in Peptide and Protein Sciences (TPPS)

Journal Abbreviation:

Trends Pept. Protein Sci.

eISSN:

2538-2446

Chairperson:

Reza Aboofazeli; PhD

Editor-in-Chief:

Bahram Kazemi; PhD

Managing Editor:

Maryam Tabarzad; PhD

Email:

TEL:

Telegram:

tipps@sbmu.ac.ir

+98 21 88648124 (8 a. m. to 4 p. m. Tehran, GMT+3.30)

+98 9380414297

Journal Trends in Peptide and Protein Sciences

@tpps_journal 

 

                            
 

Call for Papers: Electronic Volume 10 (2025)

We are pleased to invite your manuscript submissions to the electronic volume 10 (2025) of Trends in Peptide and Protein Sciences (TPPS) . Based on the new TPPS publication policies, articles will be continuously published online only from 2018 ....

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Indexing in Embase

We are pleased to announce that the journal, "Trends in Peptide and Protein Sciences" was positively evaluated in Embase indexing

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Indexing in Indexcopernicus (ICI Journals Master List)

We would like to inform you that the journal Trends in Peptide and Protein Sciences (ISSN: 2538-2535) has passed the evaluation process positively and is indexed in the ICI Journals Master List database for 2022 . Based on the information submitted in the evaluation and the analysis of the issues of the journal from 2019, Index Copernicus Experts calculated the TPPS Index Copernicus Value (ICV) for 2022. ICV 2022: 76.99

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Design, Codon Optimization, and Bioinformatic-Assisted Development of a Chimeric Circumsporozoite Protein for Malaria Vaccine Production Using Duckweed (Lemna minor) as a Plant Bioreactor

Nima Rad, Mahdi Arezoumandi, Elham Taghipour, Fateme Frootan, Ali Hatef Salmanian

Trends in Peptide and Protein Sciences, Vol. 10 No. 1 (2025), 16 March 2025, Page 1-13 (e2)

Malaria remains a serious global health problem, causing high morbidity and mortality, especially in tropical and subtropical regions. The development of effective and scalable vaccines is crucial for the control of this disease. This study investigates the application of Lemna minor (duckweed) as a novel, cost-effective, and sustainable bioreactor for the production of a chimeric circumsporozoite protein (CSP), a key antigen for malaria vaccine development. The synthetic CSP (CS712) was designed using duckweed-specific codon tables and codon-optimized to increase expression efficiency. Comprehensive bioinformatic analyses were performed to evaluate its physicochemical properties, antigenicity, allergenicity, and immunogenic potential. The optimized CS712 protein exhibited favorable properties, including high structural stability validated by Ramachandran plot and ProSA-Web, a PI of 5.31, and strong antigenicity (78.67%) without any allergenicity. Epitope predictions showed robust B and T cell responses, while molecular docking studies confirmed effective interaction with Toll-like receptor 2 (TLR2), highlighting its ability to activate innate and adaptive immunity. The results underline the potential of duckweed as a versatile plant platform for the production of recombinant vaccines. The CS712 protein proves to be a promising candidate for the development of a malaria vaccine and offers an innovative approach combining bioinformatic-based design and plant biotechnology. This study not only advances malaria vaccination strategies but also highlights the broader applicability of plant-based systems to address global health challenges through sustainable and scalable solutions.

HIGHLIGHTS

  • Duckweed was utilized as a platform for recombinant protein production.
  • A new chimeric circumsporozoite protein (CS712) from Malaria was optimized for expression in Lemna minor.
  • The designed CS712 showed strong antigenicity and no allergenicity in bioinformatic analyses.
  • Predicted epitopes highlighted robust B- and T-cell immune response potential.
  • CS712 effectively interacted with TLR2, and could activate innate and adaptive immunity.

You can listen to the audio abstract here.

Barriers to Commercialization of Cosmetic Peptides

Seyedeh Maryam Mortazavi, Hamid Reza Moghimi

Trends in Peptide and Protein Sciences, Vol. 10 No. 1 (2025), 16 March 2025, Page 1-5 (e1)

Consumer demand for safe and effective cosmetics has prompted the exploration of peptides due to their biocompatibility. However, challenges such as low skin permeability, susceptibility to degradation, and chemical instability limit their use. Additionally, regulatory and manufacturing complexities pose further hurdles. Strategies like chemical modifications, formulation adjustments, and advanced synthesis methods can help to overcome these issues. Notably, computational methods show promise in enhancing the efficacy and stability of peptide-based cosmetics.

HIGHLIGHTS

  • Peptides are eligible molecules to be applied in cosmetic products since they are biocompatible and effective.
  • There are obstacles that limit the widespread use of peptides in the cosmetic industry.
  • Conventional and in silico techniques can be employed to overcome challenges on the path to commercialization of peptides.

 

You can listen to the audio abstract here.