Leginsulin Peptide from Legumes as a Ligand of Growth Hormone-Releasing Hormone Receptor for Lipodystrophy Management in Patients with AIDS Leginsulin as a ligand of GHRH Receptor for
Trends in Peptide and Protein Sciences,
Vol. 7 (2022),
,
Page 1-7 (e5)
https://doi.org/10.22037/tpps.v7i.38445
Abstract
Since the appearance of acquired immunodeficiency syndrome (AIDS) disease, millions of people got infected, thousands are died and many suffered from its complications. One of the chronic and late symptoms of AIDS is lipodystrophy that leads to losing of fat in some parts of the body while gaining it at other organs and sites. One of the main targets in drug development for management of lipodystrophy is growth hormone-releasing hormone (GHRH) receptor. As a secondary metabolite from plants, leginsulin is a peptide with 37 amino acids and considered as hormone-like peptide. In this study, through in silico approaches, binding of leginsulin and GHRH receptor was studied. The results showed strong binding of the two molecules with docking score of -324.16 and ligand RMSD of 47.26. The molecular dynamic investigation also revealed these two proteins remained bound for almost 104 ns. Evaluation of the peptide toxicity in the body had shown that it is not toxic to the human organs and also, it doesn’t pass through the blood brain barrier. The results support the use of legumes as a source of leginsulin for potential management of lipodystrophy in the patients with AIDS.
HIGHLIGHTS
- Leginsulin is a plant secondary metabolite with 37 amino acids peptide structure.
- Binding of leginsulin and GHRH receptor was studied through in silico approaches.
- Results support the leginsulin as a potential management of lipodystrophy in AIDS patients.
- AIDS
- Leginsulin
- Lipodystrophy
- Peptides
- Protein docking
How to Cite
References
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