Effect of Nettle Extract and Pumpkin Seed on Prostate Specific Antigen and Urinary Symptoms in Patients Taking Alfa-blocker for Benign Prostatic Hyperplasia
Men's Health Journal,
Vol. 5 No. 1 (2021),
6 January 2021
,
Page e34
https://doi.org/10.22037/mhj.v5i1.36059
Abstract
Introduction: We aimed to compare the effect of nettle extract and pumpkin seed on Prostate Specific Antigen (PSA) and international prostate symptoms score (IPSS) in patients taking alfa-blocker for benign prostatic hyperplasia (BPH). Materials and Methods: For this purpose, 90 outpatients were studied in three groups, including men over 40 years of age with benign prostatic enlargement. The first group (Urtidin) contained consumers of nettle extract from Barijessence Company called Urtidin tablets with tamsulosin; the second group took tablets containing pumpkin seed extract called Prosta Barij and tamsulosin; the third group (Control) received only tamsulosin for three months. Patients were not randomly assigned to the groups PSA, IPSS, and related factors were evaluated and analyzed using SPSS software. Results: 89 patients completed the study (30/89 in Urtidin group with a mean age of 62.4±7.39 years, 29/89 in Prosta Barij group with a mean age of 65.9±7.32 years, and 30/89 in the control group with a mean age of 64.7±8.64 years). The results showed that nettle and pumpkin seed extracts affect PSA in patients taking tamsulosin for BPH. Also, after the intervention, IPSS had a significant decrease compared with baseline in both drug treatment groups. There was no significant difference in these three types of treatment. Conclusion: It seems that the desired herbal products did not have a synergistic effect with alpha blockers in the control and treatment of BPH but they can affect the serum PSA level.
Keywords:
- Benign prostatic hyperplasia
- Herbal medicine
- Nettle
- Plant extracts
- Pumpkin seeds
How to Cite
Allameh, F., Hosseininia, S. M., Lahooti, F., Naserghandi, A., & Zakeri, Y. (2021). Effect of Nettle Extract and Pumpkin Seed on Prostate Specific Antigen and Urinary Symptoms in Patients Taking Alfa-blocker for Benign Prostatic Hyperplasia. Men’s Health Journal, 5(1), e34. https://doi.org/10.22037/mhj.v5i1.36059
References
References
1. Rom M, Schatzl G, Swietek N, Rücklinger E, Kratzik C. Lower urinary tract symptoms and depression. BJU international. 2012;110(11c):E918-E21.
2. Wong SY, Hong A, Leung J, Kwok T, Leung PC, Woo J. Lower urinary tract symptoms and depressive symptoms in elderly men. Journal of affective disorders. 2006;96(1-2):83-8.
3. Glover L, Gannon K, McLoughlin J, Emberton M. Men's experiences of having lower urinary tract symptoms: factors relating to bother. BJU international. 2004;94(4):563-7.
4. Men C, Wang M, Aiyireti M, Cui Y. The efficacy and safety of urtica dioica in treating benign prostatic hyperplasia: a systematic review and meta-analysis. African Journal of Traditional, Complementary and Alternative Medicines. 2016;13(2):143-50.
5. Ghassemi Dehkordi N, Sajjadi S, Ghannadi A, Amanzadeh Y, Azadbakht M, Asghari G. Iranian herbal pharmacopoeia (IHP). Hakim R J. 2003;6(3):63-9.
6. Zargari A. Medicinal plants. Zargari, A ed: University of Tehran Publication; 2004 2004.
7. The Tropical Plant Database. - Nettles (Urtica dioica) Database file in the Tropical Plant Database for herbal remedies available.
8. Babashpour-Asl M, Baleghi M, Sajadi P, Golalipour M. Different Aspects and Results of Modern Studies of Urtica Dioica: A Review. J Babol Univ Med Sci. 2014;16(S1):47-54.
9. Fischer M, Wilbert D. Test of phytomedicine for treatment of benign prostatic hyperplasia (BPH). Benigne Prostahyperplasie III: Klinische und experimentelle Urologie. 1992;22:79-84.
10. GHORBANI RA, GHORBANI RN, GHORBANI RZ, GHORBANI RS. Study of nettle hydro alcoholic extraction (Urtica dioica) influence on spermatogenesis and Testosterone, spermatogenesis hormones, changes in rats. 2014.
11. Ghorbanibirgani A, Khalili A, Zamani L. The efficacy of stinging nettle (Urtica dioica) in patients with benign prostatic hyperplasia: a randomized double-blind study in 100 patients. Iranian Red Crescent Medical Journal. 2013;15(1):9.
12. Hryb D, Khan M, Romas N, Rosner W. The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes. Planta medica. 1995;61(01):31-2.
13. Bilia AR, Frater-Schroder M, Krenn L, Steinhoff B. ESCOP's role in defining a scientific foundation for herbal medicinal products. Phytomedicine: International Journal of Phytotherapy & Phytopharmacology. 2010;18(1):88-90.
14. Sweetman SC. Martindale: the complete drug reference2005.
15. Strobl M. Delta-7-Sterole und Delta-7-Sterolglykoside aus Samen von Cucurbita pepo L: lmu; 2004.
16. Friederich M, Theurer C, Schiebel-Schlosser G. Prosta Fink Forte®-Kapseln in der Behandlung der benignen Prostatahyperplasie. Eine multizentrische Anwendungsbeobachtung an 2245 Patienten. Complementary Medicine Research. 2000;7(4):200-4.
17. Hong H, Kim C-S, Maeng S. Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia. Nutrition research and practice. 2009;3(4):323-7.
18. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urologia internationalis. 2015;94(3):286-95.
19. Akang E, Oremosu A, Dosumu O, Noronha C, Okanlawon A. The effect of fluted pumpkin (Telferia occidentalis) seed oil (FPSO) on testis and semen parameters. Agr Biol J North Am. 2010;1:697-703.
20. Damiano R, Cai T, Fornara P, Franzese CA, Leonardi R, Mirone V. The role of Cucurbita pepo in the management of patients affected by lower urinary tract symptoms due to benign prostatic hyperplasia: A narrative review. Archivio Italiano di Urologia e Andrologia. 2016;88(2):136-43.
21. Katzung B. Basic & Clinical Pharmacology, USA: McGraw-Hill Education. 2018.
22. Information for Urtidin Barij Coated Tablets available on Website of Barij Essence Pharmaceutical Co.
23. Information for Prosta Barij available on Website of Barij Essence Pharmaceutical Co.
24. Buck A. Is there a scientific basis for the therapeutic effects of serenoa repens in benign prostatic hyperplasia? Mechanisms of action. The Journal of urology. 2004;172(5):1792-9.
25. Levin R, Das A. A scientific basis for the therapeutic effects of Pygeum africanum and Serenoa repens. Urological research. 2000;28(3):201-9.
26. Madersbacher S, Berger I, Ponholzer A, Marszalek M. Plant extracts: sense or nonsense? Current opinion in urology. 2008;18(1):16-20.
27. S. Gravas (Chair) JNC, M. Gacci, C. Gratzke, T.R.W. Herrmann, C. Mamoulakis, M. Rieken, M.J. Speakman, K.A.O. Tikkinen and I.K. Guidelines Associates: M. Karavitakis, S. Malde, V. Sakalis, R. Umbach. . Management of Non-neurogenic Male LUTS Guideline of european association of urology(EAU).
28. Reza Avizeh GANH, Pour Mahdi boroujeni Mahdi, Dashtegol Shahrzad. The effect of hydroalcoholic extract of nettle root on the dimensions of the prostate gland of dogs with Using ultrasonography. IranianVeterinary Journal. 2012;9(2):p. 17-23.
29. Hamvas A, Corradi G, Hegedüs M, Frang D. Experience with the Peponen® capsule in the management of benign prostatic hyperplasia. International urology and nephrology. 1991;23(1):51-5.
30. Safarinejad MR. Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. Journal of herbal pharmacotherapy. 2005;5(4):1-11.
31. Melo EA, Bertero EB, Rios L, Mattos Jr D. Evaluating the efficiency of a combination of Pygeum africanum and stinging nettle (Urtica dioica) extracts in treating benign prostatic hyperplasia (BPH): double-blind, randomized, placebo controlled trial. Int Braz J Urol. 2002;28(5):418-25.
32. Sener B, Orhan I, Ozcelik B, Kartal M, Aslan S, Ozbilen G. Antimicrobial and antiviral activities of two seed oil samples of Cucurbita pepo L. and their fatty acid analysis. Natural Product Communications. 2007;2(4):1934578X0700200409.
33. Nawfal T, Daher C, Mroueh M, Baroody K, Nasser S, Baroody G. The effects of Cucurbita pepo seeds on testosterone induced benign prostatic hyperplasia. Planta Medica. 2011;77(12):PF75.
34. Nahata A, Dixit V. Ameliorative effects of stinging nettle (Urtica dioica) on testosterone‐induced prostatic hyperplasia in rats. Andrologia. 2012;44:396-409.
35. Shirvan MK, Mahboob MRD, Masuminia M, Mohammadi S. Pumpkin seed oil (prostafit) or prazosin? Which one is better in the treatment of symptomatic benign prostatic hyperplasia. J Pak Med Assoc. 2014;64(6):683-5.
36. Kevin T. McVary M, Chair; Claus G. Roehrborn, MD, Co-Chair; Andrew L. Avins, MD, MPH; Michael J. Barry, MD; Reginald C. Bruskewitz, MD; Robert F. Donnell, MD; Harris E. Foster, Jr., MD; Chris M. Gonzalez, MD; Steven A. Kaplan, MD; David R. Penson, MD; James C. Ulchaker, MD; John T. Wei, MD. Management of Benign Prostatic Hyperplasia on American Urological.
37. Leibbrand M, Siefer S, Schön C, Perrinjaquet-Moccetti T, Kompek A, Csernich A, et al. Effects of an oil-free hydroethanolic pumpkin seed extract on symptom frequency and severity in men with benign prostatic hyperplasia: a pilot study in humans. Journal of medicinal food. 2019;22(6):551-9.
1. Rom M, Schatzl G, Swietek N, Rücklinger E, Kratzik C. Lower urinary tract symptoms and depression. BJU international. 2012;110(11c):E918-E21.
2. Wong SY, Hong A, Leung J, Kwok T, Leung PC, Woo J. Lower urinary tract symptoms and depressive symptoms in elderly men. Journal of affective disorders. 2006;96(1-2):83-8.
3. Glover L, Gannon K, McLoughlin J, Emberton M. Men's experiences of having lower urinary tract symptoms: factors relating to bother. BJU international. 2004;94(4):563-7.
4. Men C, Wang M, Aiyireti M, Cui Y. The efficacy and safety of urtica dioica in treating benign prostatic hyperplasia: a systematic review and meta-analysis. African Journal of Traditional, Complementary and Alternative Medicines. 2016;13(2):143-50.
5. Ghassemi Dehkordi N, Sajjadi S, Ghannadi A, Amanzadeh Y, Azadbakht M, Asghari G. Iranian herbal pharmacopoeia (IHP). Hakim R J. 2003;6(3):63-9.
6. Zargari A. Medicinal plants. Zargari, A ed: University of Tehran Publication; 2004 2004.
7. The Tropical Plant Database. - Nettles (Urtica dioica) Database file in the Tropical Plant Database for herbal remedies available.
8. Babashpour-Asl M, Baleghi M, Sajadi P, Golalipour M. Different Aspects and Results of Modern Studies of Urtica Dioica: A Review. J Babol Univ Med Sci. 2014;16(S1):47-54.
9. Fischer M, Wilbert D. Test of phytomedicine for treatment of benign prostatic hyperplasia (BPH). Benigne Prostahyperplasie III: Klinische und experimentelle Urologie. 1992;22:79-84.
10. GHORBANI RA, GHORBANI RN, GHORBANI RZ, GHORBANI RS. Study of nettle hydro alcoholic extraction (Urtica dioica) influence on spermatogenesis and Testosterone, spermatogenesis hormones, changes in rats. 2014.
11. Ghorbanibirgani A, Khalili A, Zamani L. The efficacy of stinging nettle (Urtica dioica) in patients with benign prostatic hyperplasia: a randomized double-blind study in 100 patients. Iranian Red Crescent Medical Journal. 2013;15(1):9.
12. Hryb D, Khan M, Romas N, Rosner W. The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes. Planta medica. 1995;61(01):31-2.
13. Bilia AR, Frater-Schroder M, Krenn L, Steinhoff B. ESCOP's role in defining a scientific foundation for herbal medicinal products. Phytomedicine: International Journal of Phytotherapy & Phytopharmacology. 2010;18(1):88-90.
14. Sweetman SC. Martindale: the complete drug reference2005.
15. Strobl M. Delta-7-Sterole und Delta-7-Sterolglykoside aus Samen von Cucurbita pepo L: lmu; 2004.
16. Friederich M, Theurer C, Schiebel-Schlosser G. Prosta Fink Forte®-Kapseln in der Behandlung der benignen Prostatahyperplasie. Eine multizentrische Anwendungsbeobachtung an 2245 Patienten. Complementary Medicine Research. 2000;7(4):200-4.
17. Hong H, Kim C-S, Maeng S. Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia. Nutrition research and practice. 2009;3(4):323-7.
18. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urologia internationalis. 2015;94(3):286-95.
19. Akang E, Oremosu A, Dosumu O, Noronha C, Okanlawon A. The effect of fluted pumpkin (Telferia occidentalis) seed oil (FPSO) on testis and semen parameters. Agr Biol J North Am. 2010;1:697-703.
20. Damiano R, Cai T, Fornara P, Franzese CA, Leonardi R, Mirone V. The role of Cucurbita pepo in the management of patients affected by lower urinary tract symptoms due to benign prostatic hyperplasia: A narrative review. Archivio Italiano di Urologia e Andrologia. 2016;88(2):136-43.
21. Katzung B. Basic & Clinical Pharmacology, USA: McGraw-Hill Education. 2018.
22. Information for Urtidin Barij Coated Tablets available on Website of Barij Essence Pharmaceutical Co.
23. Information for Prosta Barij available on Website of Barij Essence Pharmaceutical Co.
24. Buck A. Is there a scientific basis for the therapeutic effects of serenoa repens in benign prostatic hyperplasia? Mechanisms of action. The Journal of urology. 2004;172(5):1792-9.
25. Levin R, Das A. A scientific basis for the therapeutic effects of Pygeum africanum and Serenoa repens. Urological research. 2000;28(3):201-9.
26. Madersbacher S, Berger I, Ponholzer A, Marszalek M. Plant extracts: sense or nonsense? Current opinion in urology. 2008;18(1):16-20.
27. S. Gravas (Chair) JNC, M. Gacci, C. Gratzke, T.R.W. Herrmann, C. Mamoulakis, M. Rieken, M.J. Speakman, K.A.O. Tikkinen and I.K. Guidelines Associates: M. Karavitakis, S. Malde, V. Sakalis, R. Umbach. . Management of Non-neurogenic Male LUTS Guideline of european association of urology(EAU).
28. Reza Avizeh GANH, Pour Mahdi boroujeni Mahdi, Dashtegol Shahrzad. The effect of hydroalcoholic extract of nettle root on the dimensions of the prostate gland of dogs with Using ultrasonography. IranianVeterinary Journal. 2012;9(2):p. 17-23.
29. Hamvas A, Corradi G, Hegedüs M, Frang D. Experience with the Peponen® capsule in the management of benign prostatic hyperplasia. International urology and nephrology. 1991;23(1):51-5.
30. Safarinejad MR. Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. Journal of herbal pharmacotherapy. 2005;5(4):1-11.
31. Melo EA, Bertero EB, Rios L, Mattos Jr D. Evaluating the efficiency of a combination of Pygeum africanum and stinging nettle (Urtica dioica) extracts in treating benign prostatic hyperplasia (BPH): double-blind, randomized, placebo controlled trial. Int Braz J Urol. 2002;28(5):418-25.
32. Sener B, Orhan I, Ozcelik B, Kartal M, Aslan S, Ozbilen G. Antimicrobial and antiviral activities of two seed oil samples of Cucurbita pepo L. and their fatty acid analysis. Natural Product Communications. 2007;2(4):1934578X0700200409.
33. Nawfal T, Daher C, Mroueh M, Baroody K, Nasser S, Baroody G. The effects of Cucurbita pepo seeds on testosterone induced benign prostatic hyperplasia. Planta Medica. 2011;77(12):PF75.
34. Nahata A, Dixit V. Ameliorative effects of stinging nettle (Urtica dioica) on testosterone‐induced prostatic hyperplasia in rats. Andrologia. 2012;44:396-409.
35. Shirvan MK, Mahboob MRD, Masuminia M, Mohammadi S. Pumpkin seed oil (prostafit) or prazosin? Which one is better in the treatment of symptomatic benign prostatic hyperplasia. J Pak Med Assoc. 2014;64(6):683-5.
36. Kevin T. McVary M, Chair; Claus G. Roehrborn, MD, Co-Chair; Andrew L. Avins, MD, MPH; Michael J. Barry, MD; Reginald C. Bruskewitz, MD; Robert F. Donnell, MD; Harris E. Foster, Jr., MD; Chris M. Gonzalez, MD; Steven A. Kaplan, MD; David R. Penson, MD; James C. Ulchaker, MD; John T. Wei, MD. Management of Benign Prostatic Hyperplasia on American Urological.
37. Leibbrand M, Siefer S, Schön C, Perrinjaquet-Moccetti T, Kompek A, Csernich A, et al. Effects of an oil-free hydroethanolic pumpkin seed extract on symptom frequency and severity in men with benign prostatic hyperplasia: a pilot study in humans. Journal of medicinal food. 2019;22(6):551-9.
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