The correlation between Epicardial Adipose Tissue Thickness and Severity of Coronary Artery Disease; An Echocardiographic Evaluation
Archives of Men's Health,
Vol. 5 No. 1 (2021),
6 January 2021
,
Page e20
https://doi.org/10.22037/mhj.v5i1.34619
Abstract
Introduction: Epicardial adipose tissue (EAT), as a visceral adipose tissue, is associated with various cardio-metabolic risk factors, such as fasting plasma glucose, systemic blood pressure and serum low-density lipoprotein. Using EAT thickness as a cost-efficient assessment tool for stratifying the risk of coronary artery disease (CAD) is still controversial. Methods: We enrolled 250 consecutive patients who underwent coronary angiography during 2016 and gathered their demographic. Echocardiographic examinations were performed in the left lateral decubitus position and EAT thickness was measured in standard parasternal long-axis (PLAX) and apical four chamber views. Results: 250 patients including 156 men (mean age: 57.66) and 94 women (mean age: 61.19) were enrolled. Two vessel disease (2VD) and three vessel disease (3VD) were significantly associated with hyperlipidemia (P: 0.04), CKD (Chronic Kidney Disease) (P: 0.001), diabetes mellitus (P: 0.001) and smoking habits (P: 0.001). Also, EAT thickness in PLAX view (P<0.001), and not four chamber view (P: 0.136), was significantly associated and correlated with increased involvement of coronary arteries in catheterization. Conclusion: Although EAT thickness in PLAX view was significantly correlated with 2VD and 3VD, this correlation was not strong and the accuracy of this approach needs further evaluation.
- Epicardial Adipose Tissue
- Coronary artery disease
- Echocardiography
- Coronary angiography
- Atherosclerosis
How to Cite
References
2. Baker, A. R. et al. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabetol 5, 1 (2006).
3. Mazurek, T. et al. Human Epicardial Adipose Tissue Is a Source of Inflammatory Mediators. Circulation 108, 2460–2466 (2003).
4. Chau, Y.-Y. et al. Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source. Nat. Cell Biol. 16, 367–75 (2014).
5. Wang, T.-D. et al. Relations of epicardial adipose tissue measured by multidetector computed tomography to components of the metabolic syndrome are region-specific and independent of anthropometric indexes and intraabdominal visceral fat. J. Clin. Endocrinol. Metab. 94, 662–669 (2009).
6. Sinha, S. K. et al. Epicardial Adipose Tissue Thickness and Its Association With the Presence and Severity of Coronary Artery Disease in Clinical Setting: A Cross-Sectional Observational Study. J. Clin. Med. Res. 8, 410–9 (2016).
7. Eroglu, S. et al. Epicardial adipose tissue thickness by echocardiography is a marker for the presence and severity of coronary artery disease. Nutr. Metab. Cardiovasc. Dis. 19, 211–7 (2009).
8. Wu, F.-Z., Chou, K.-J., Huang, Y.-L. & Wu, M.-T. The relation of location-specific epicardial adipose tissue thickness and obstructive coronary artery disease: systemic review and meta-analysis of observational studies. BMC Cardiovasc. Disord. 14, 62 (2014).
9. Wang, T. et al. Correlation of echocardiographic epicardial fat thickness with severity of coronary artery disease in patients with acute myocardial infarction. Echocardiography 31, 1177–1181 (2014).
10. Torpy, J. M., Burke, A. E. & Glass, R. M. Coronary heart disease risk factors. Jama 302, 2388 (2009).
- Abstract Viewed: 182 times
- pdf Downloaded: 164 times