Non-Disulfide-Bridges Peptides from Scorpion Venoms: Targets for Novel Drugs Against Antibiotic-Resistant Pathogens Novel drugs against antibiotic-resistant pathogens
International Pharmacy Acta,
Vol. 6 No. 1 (2023),
1 January 2023
,
Page e11: 1-7
https://doi.org/10.22037/ipa.v6i1.42469
Abstract
Overuse of antibiotics in recent decades has led to the emergence of antibiotic-resistant infections. Drug resistance is now regarded as a major threat to global public health. For this reason, the phenomenon of antibiotic-resistance caused that health care professionals looking for new types of effective antimicrobial agents against the threat of traditional antibiotic-resistant pathogens. In their role as effector molecules in the innate immune response, antimicrobial peptides (AMPs) carry out numerous important tasks. Through interactions with negatively charged phospholipids, cationic AMPs have the ability to damage microbial cell membranes. Positively charged cationic AMPs reduce the risk of resistance, which is a major advantage compared to available antibiotics. In recent decades, a large number of non-disulfide-Bridges peptides (NDBPs) with medicinal properties have been isolated from the venom of the scorpion. Therefore, scorpion venom is a tremendous source of raw AMPs for design and development of novel drugs against antibiotic-resistant pathogens. NDBPs are effective against different types of antibiotic-resistance bacterial strains, including methicillin-resistant staphylococcus aureus (MRSA). In this review, a diversity of NDBPs that are effective against the resistant pathogens was discussed.
- Non-Disulfide-Bridges peptides
- Scorpion venom
- Antimicrobial activity
- Novel drugs
- Antibiotic-resistant pathogens
How to Cite
References
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