ISSN: 2645-3258
Vol. 5 No. 1 (2022)
Comparison of some physical parameters of different brands of acyclovir tablets marketed in Iran Quality control of acyclovir tablets
International Pharmacy Acta,
Vol. 5 No. 1 (2022),
,
Page e11: 1-5
https://doi.org/10.22037/ipa.v5i1.38921
Abstract
Acyclovir is the nucleoside analogue of guanosine, which is used as an antiviral drug. Since the quality requirements set for a higher quality product are necessary, the purpose of this study was to investigate the quality control characteristics of selected Iranian brands of acyclovir 400 mg tablets. Different brands and batches of acyclovir tablets were collected and subjected to various quality control tests such as weight variation, friability, hardness, disintegration and dissolution. The results obtained for all the selected brands of acyclovir were in acceptable range and, it can be stated that all brands of acyclovir tablets met the specification in quality tests.
- Acyclovir
- Quality control
- Physico-chemical properties
How to Cite
References
Wei Y-P, Yao L-Y, Wu Y-Y, Liu X, Peng L-H, Tian Y-L, et al. Critical Review of Synthesis, Toxicology and Detection of Acyclovir. Molecules. 2021 Oct 29;26(21):6566.
Hassan H, Adam SK, Othman F, Shamsuddin AF, Basir R. Antiviral Nanodelivery Systems: Current Trends in Acyclovir Administration. J Nanomater. 2016;2016:1–8.
National Formulary of Iran [Internet]. [cited 2022 Jun 10]. Available from: https://irc.fda.gov.ir/nfi
Chow S-C. Pharmaceutical Validation and Process Controls in Drug Development. Drug Inf J. 1997 Oct 30;31(4):1195–201.
Paul S, Sun CC. Systematic evaluation of common lubricants for optimal use in tablet formulation. Eur J Pharm Sci. 2018 May;117(January):118–27.
Haleem RM, Salem MY, Fatahallah FA, Abdelfattah LE. Quality in the pharmaceutical industry – A literature review. Saudi Pharm J. 2015 Oct;23(5):463–9.
Abebe K, Beressa TB, Yimer BT. In-vitro Evaluations of Quality Control Parameters of Paracetamol Tablets Marketed in Gondar City, Northwest Ethiopia. Drug Healthc Patient Saf. 2020 Dec;Volume 12:273–9.
The United States pharmacopeia. National formulary. Vol. 1. Rockville (MD): United States Pharmacopeial Convention; 2016. Tablet Friability, p.1609;
Abebe S, Ketema G, Kassahun H. In vitro comparative quality assessment of different brands of furosemide tablets marketed in northwest Ethiopia. Drug Des Devel Ther. 2020;14:5119–28.
The United States pharmacopeia. National formulary. Vol. 1. Rockville (MD): United States Pharmacopeial Convention; 2016. Tablet Breaking Force. p.1610;
Dulla O, Sultana S, Shohag Hosen M. In vitro comparative quality evaluation of different brands of esomeprazole tablets available in selected community pharmacies in Dhaka, Bangladesh. BMC Res Notes. 2018 Dec 20;11(1):184.
The United States pharmacopeia. National formulary. Vol. 2. Rockville (MD): United States Pharmacopeial Convention; 2016.Acyclovir Tablets. p.2342.;
The United States pharmacopeia. National formulary. Vol. 1. Rockville (MD): United States Pharmacopeial Convention; 2016. Disintegration. p.537;
The United States pharmacopeia. National formulary. Vol. 1. Rockville (MD): United States Pharmacopeial Convention; 2016. Dissolution. p.540;
European Medicines Agency. ICH Topic Q4B Annex 5 Disintegration Test General Chapter. 2008;(June):1–7.
- Abstract Viewed: 71 times
- IPA-2022-Vol5-e11-38921 Downloaded: 6 times