Tyrosinase Inhibitory Activity of Selected Plants Based on Iranian Traditional Medicine Detection of mushroom tyrosinase inhibitors based on ITM
International Pharmacy Acta,
Vol. 5 No. 1 (2022),
Page e4: 1-5
Discovery of safe and stable skin whitening agents for medical and cosmetic purposes has drawn attention in recent years. For the same reason, this study was undertaken to evaluate tyrosinase inhibitory activity of some medicinal plants introduced in Iranian Traditional Medicine as hypopigmenting agents. In recent research, tyrosinase inhibitory effect and antioxidant activity of selected plants were evaluated using mushroom tyrosinase inhibitory assay and DPPH radical scavenging test and, in addition, total phenol content of extracts was measured. Out of nine aqueous extracts of selected plants, the effect of Ricinus communis L. and Nepeta glomerulosa Boiss. on tyrosinase inhibition was significant with 71.99 and 89.98 percent inhibition, respectively. Moreover, Pistacia atlantica L. showed the highest total phenol content with the most potent DPPH radical scavenging effect and high anti-tyrosinase activity with 59.07 percent of inhibition. The obtained results suggest that Ricinus communis, Nepeta glomerulosa and Pistacia atlantica could be good candidates for further investigation to find novel agents for skin hyperpigmentation.
- Antioxidant activity
- Nepeta glomerulosa
- Pistacia atlantica
- Ricinus communis
- Mushroom tyrosinase inhibitors
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