Measurement solubility of Acetylsalicylic Acid in water and alcohols
International Pharmacy Acta,
Vol. 3 No. 1 (2020),
14 December 2020
,
Page 3e11:1-7
https://doi.org/10.22037/ipa.v3i1.32231
Abstract
Low aqueous solubility of drug is one of the problems in pharmaceutical industry and the enhancement of the solubility of these poorly soluble drugs has recently attracted the consideration of researchers. In this way, one of the essential methods to overcome this challenge is to use co-solvents. In this study, a set of experiments was conducted to measure the solubility and density of Acetylsalicylic Acid as a painkiller drug in water, 1-octanol, ethanol, methanol, and ethylene glycol as solvents in the temperature range of 298 to 330 K. Furthermore, the experiments are carried out at 298K in the binary mixture of solvents to investigate the interaction effect of another solvent or anti-solvent in different percentages of mixtures. The results of this investigation revealed that using binary solution of water and ethanol, as a solvent aid, was able to increase the solubility especially in high percentage of ethanol. Moreover, to indicate the applicability of simple empirical model, the experimental data was used to optimize two adjustable parameters of the selected model. In future research, a successful thermodynamic models will be offered based on gathered data for prediction of solubility in the different temperature with high accuracy.
- Solubility
- Acetylsalicylic Acid
- co-solvent
- antisolvent
- Pharmaceutical Research
How to Cite
References
[2] Aneta Pobudkowska, Urszula Domanska, Barbara A. Jurkowski, Katarzyna Dymczuk, Fluid Phase Equilibria 392 (2015) 56–64
[3] Gustavo D. Maia, Marco Giulietti, J. Chem. Eng. Data 2008, 53, 256–258
[4] Wanxin Li, Ali Farajtabar, Rong Xing, Yiting Zhu, Hongkun Zhao, J. Chem. Thermodynamics 142 (2020) 106010
[5] Faiyaz Shakeel, Fars K. Alanazi, Ibrahim A. Alsarra, NazrulHaq, Journal of Molecular Liquids 191 (2014) 68–72
[6] Chao Cheng, Yang Cong, Cunbin Du, Jian Wang, Hongkun Zhao, J. Chem. Thermodynamics 104 (2017) 50–60
[7] Jackson A. Jiménez and Fleming Martínez, J. Braz. Chem. Soc., Vol. 17, No. 1, 125-134, 2006
[8] Samir D.Roy and Gordon L.Flynn, Pharmaceutical Research, Vol.5, No.9, 1988
[9] Samir D.Roy and Gordon L.Flynn, Pharmaceutical Research, Vol.6, No.2, 1989
[10] Chao Cheng, Yang Cong, Long Meng, Jian wang, GanBing Yao, Hongkun Zhao, J. Chem. Thermodynamics 97 (2016) 158–166
[11] Juliana MANRIQUE and Fleming MARTÍNEZ, J. Pharm. 26 (3): 344-354 (2007)
[12] Xinbao Li, Chao Cheng, Yang Cong, Cunbin Du, Hongkun Zhao, J. Chem. Thermodynamics 105 (2017) 362–374.
[13] G.B. Yao, Z.X. Xia, Z.H. Li, C. Shao, Fluid Phase Equilibria. 417 (2016) 242–247.
[14] G.B. Yao, Z.H. Li, Z.X. Xia, Q.C. Yao, J. Chem. Thermodyn. 103 (2016) 218–227.
[15] C. Held, L.F. Cameretti, G. Sadowski, Ind. Eng. Chem. Res. 50 (2011) 131–141.
[16] M. Sajadian, K. Peyvandi, Fluid Phase Equilibria 425 (2016) 152–157.
[17] Florey, K. Acetylsalicylic Acid. Analytical Profiles of Drug Substances 8; Academic Press Inc.: London, 1979.
[18] Hamer, W. E.; Philips, G. V. Aspirin Crystallization, United States Patent Office 2,890,240, Monsanto Chemicals Limited: London, 1959.
[19] Prausnitz, J. M.; Lichtenthaler, R. N.; Gomes de Azevedo, E. Molecular Thermodynamics of Fluid-Phase Equilibria, 2nd ed.; Prentice-Hall Inc.: Englewood, USA, 1986.
[20] Smith, J. M.; Van Ness, H. C. Introdução à Termodinâmica da Engenharia Química. Terceira Edição, trad. Macedo, H., Ed.; Guanabara Koogan: Rio de Janeiro, Brazil, 1980.
- Abstract Viewed: 1193 times
- PDF Downloaded: 1138 times