Natural killer cell: New suspect on cytokine storm in COVID-19 infection Natural killer cell: New suspect on cytokine storm
Archives of Advances in Biosciences,
Vol. 12 No. 4 (2021),
12 October 2021
,
Page 58-62
https://doi.org/10.22037/aab.v12i4.36514
Abstract
Context: Various studies show that contracting the Covid 19 disease can affect the normal functioning of the immune system. In some patients, lack of stimulation of the specific immune system causes excessive innate immune activity and secretion of inflammatory cytokines.
Evidence Acquisition: It seems that the occurrence of cytokine storm depends on various factors. One of the immune system cells that can play an important role in cytokine storm is Natural killer (NK) cell. Thus, more attention should be paid to the role of NK cell in patients with Covid-19.
Results: In this article, we seek to examine the role of NK cell in cytokine storms.
Conclusion: Perhaps the difference between the characteristics of NK cell in children and adults is due to the difference in the severity of symptoms after infection with Covid-19.
- Natural killer cell, cytokine storm, COVID-19
How to Cite
References
Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, Lanier LL, et al. Innate or adaptive immunity? The example of natural killer cells. Science. 2011; 331(6013):44-9. [DOI:10.1126/science.1198687] [PMID] [PMCID]
Golden‐Mason L, Rosen HR. Natural killer cells: Multifaceted players with key roles in hepatitis C immunity. Immunol Rev. 2013; 255(1):68-81. [DOI:10.1111/imr.12090] [PMID] [PMCID]
Carvelli J, Piperoglou Ch, Bourenne J, Farnarier C, Banzet N, Demerlé C, et al. Imbalance of circulating innate lymphoid cell subpopulations in patients with septic shock. Front Immunol. 2019; 10:2179. [DOI:10.3389/fimmu.2019.02179] [PMID] [PMCID]
Dessouki O, Kamiya Y, Nagahama H, Tanaka M, Suzu Sh, Sasaki Y, et al. Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment. Biochem Biophys Res Commun. 2010; 393(2):331-7. [DOI:10.1016/j.bbrc.2010.02.008] [PMID]
Golden-Mason L, Madrigal-Estebas L, McGrath E, Conroy MJ, Ryan EJ, Hegarty JE, et al. Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure. Gut. 2008; 57(8):1121-8. [DOI:10.1136/gut.2007.130963] [PMID]
Lee S, Watson MW, Flexman JP, Cheng W, Hammond T, Price P. Increased proportion of the CD56bright NK cell subset in patients chronically infected with hepatitis C virus (HCV) receiving interferon‐α and ribavirin therapy. J Med Virol. 2010; 82(4):568-74. [DOI:10.1002/jmv.21742] [PMID]
Lin AW, Gonzalez SA, Cunningham‐Rundles S, Dorante G, Marshall S, Tignor A, Ha C, et al. CD56+dim and CD56+bright cell activation and apoptosis in hepatitis C virus infection. Clin Exp Immunol. 2004; 137(2):408-16. [DOI:10.1111/j.1365-2249.2004.02523.x] [PMID] [PMCID]
Oliviero B, Mele D, Degasperi E, Aghemo A, Cremonesi E, Rumi MG, et al. Natural killer cell dynamic profile is associated with treatment outcome in patients with chronic HCV infection. J Hepatol. 2013; 59(1):38-44. [DOI:10.1016/j.jhep.2013.03.003] [PMID]
Lutz CT, Moore MB, Bradley S, Shelton BJ, Lutgendorf SK. Reciprocal age related change in natural killer cell receptors for MHC class I. Mech Ageing Dev. 2005; 126(6-7):722-31. [DOI:10.1016/j.mad.2005.01.004] [PMID] [PMCID]
Sundström Y, Nilsson C, Lilja G, Kärre K, Troye‐Blomberg M, Berg L. The expression of human natural killer cell receptors in early life. Scand J Immunol. 2007; 66(2‐3):335-44. [DOI:10.1111/j.1365-3083.2007.01980.x] [PMID]
Entezami K, Khazrae M. [Study & determination of natural killer cells in the peripheral blood of healthy population of Iran University of Medical Sciences within different age group (18-60 years) (Persian)]. Razi J Med Sci. 2004; 10(37):687-92. http://rjms.iums.ac.ir/article-1-216-en.html
Augusto DG, Lobo-Alves SC, Melo MF, Pereira NF, Petzl-Erler ML. Activating KIR and HLA Bw4 ligands are associated to decreased susceptibility to pemphigus foliaceus, an autoimmune blistering skin disease. PloS One. 2012; 7(7):e39991. [DOI:10.1371/journal.pone.0039991] [PMID] [PMCID]
Howard RR, Fasano CS, Frey L, Miller CH. Reference intervals of CD3, CD4, CD8, CD4/CD8, and absolute CD4 values in Asian and non‐Asian populations. Cytometry. 1996; 26(3):231-2. [DOI:10.1002/(SICI)1097-0320(19960915)26:3<231::AID-CYTO9>3.0.CO;2-H]
Qin HD, Shi YQ, Liu ZH, Li ZG, Wang HS, Wang H, et al. Effect of chlorogenic acid on mast cell-dependent anaphylactic reaction. Int Immunopharmacol. 2010; 10(9):1135-41. [DOI:10.1016/j.intimp.2010.06.018] [PMID]
Reichert T, DeBruyère M, Deneys V, Tötterman T, Lydyard P, Yuksel F, et al. Lymphocyte subset reference ranges in adult Caucasians. Clin Immunol Immunopathol. 1991; 60(2):190-208. [DOI:10.1016/0090-1229(91)90063-G]
Dhaliwal JS, Balasubramaniam T, Quek CK, Gill HK, Nasuruddin BA. Reference ranges for lymphocyte subsets in a defined Malaysian population. Singapore Med J. 1995; 36(3):288-91. [PMID]
Shahabuddin S. Quantitative differences in CD8+ lymphocytes, CD4/CD8 ratio, NK cells, and HLA-DR+-activated T cells of racially different male populations. Clin Immunol Immunopathol. 1995; 75(2):168-70. [DOI:10.1006/clin.1995.1067] [PMID]
Jiang K, Zhu FM, Lv QF, Yan LX. Distribution of killer cell immunoglobulin‐like receptor genes in the Chinese Han population. Tissue Antigens. 2005; 65(6):556-63. [DOI:10.1111/j.1399-0039.2005.00412.x] [PMID]
Yawata M, Yawata N, McQueen KL, Cheng NW, Guethlein LA, Rajalingam R, et al. Predominance of group AKIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression. Immunogenetics. 2002; 54(8):543-50. [DOI:10.1007/s00251-002-0497-x] [PMID]
Wauquier N, Padilla C, Becquart P, Leroy E, Vieillard V. Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection. Immunogenetics. 2010; 62(11-12):767-71. [DOI:10.1007/s00251-010-0480-x] [PMID] [PMCID]
Thananchai H, Gillespie G, Martin MP, Bashirova A, Yawata N, Yawata M, et al. Cutting edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. J Immunol. 2007; 178(1):33-7. [DOI:10.4049/jimmunol.178.1.33] [PMID]
Pelekanou A, Tsangaris I, Kotsaki A, Karagianni V, Giamarellou H, Armaganidis A, et al. Decrease of CD4-lymphocytes and apoptosis of CD14-monocytes are characteristic alterations in sepsis caused by ventilator-associated pneumonia: Results from an observational study. Crit Care. 2009; 13(6):R172. [DOI:10.1186/cc8148] [PMID] [PMCID]
Zheng M, Gao Y, Wang G, Song G, Liu S, Sun D, et al. Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell Mol Immunol. 2020; 17(5):533-5. [DOI:10.1038/s41423-020-0402-2] [PMID] [PMCID]
Guo Y, Luan L, Patil NK, Wang J, Bohannon JK, Rabacal W, et al. IL-15 enables septic shock by maintaining NK cell integrity and function. J Immunol. 2017; 198(3):1320-33. [DOI:10.4049/jimmunol.1601486] [PMID] [PMCID]
de Pablo R, Monserrat J, Torrijos C, Martín M, Prieto A, Alvarez-Mon M. The predictive role of early activation of natural killer cells in septic shock. Crit Care. 2012; 16(2):413. [DOI:10.1186/cc11204] [PMID] [PMCID]
Roder JC, Argov S, Klein M, Petersson C, Kiessling R, Andersson K, et al. Target-effector cell interaction in the natural killer cell system. V. Energy requirements, membrane integrity, and the possible involvement of lysosomal enzymes. Immunology. 1980; 40(1):107-16. [PMID] [PMCID]
Kiykim A, Ogulur I, Baris S, Salzer E, Karakoc-Aydiner E, Ozen AO, et al. Potentially beneficial effect of hydroxychloroquine in a patient with a novel mutation in protein kinase Cδ deficiency. J Clin Immunol. 2015; 35(6):523-6. [DOI:10.1007/s10875-015-0178-9] [PMID]
Fox RI. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Semin Arthritis Rheum. 1993; 23(2 Suppl 1):82-91. [DOI:10.1016/S0049-0172(10)80012-5]
Green MRJ, Kennell ASM, Larche MJ, Seifert MH, Isenberg DA, Salaman MR. Natural killer cell activity in families of patients with systemic lupus erythematosus: Demonstration of a killing defect in patients. Clin Exp Immunol. 2005; 141(1):165-73. [DOI:10.1111/j.1365-2249.2005.02822.x] [PMID] [PMCID]
Sacre K, Criswell LA, McCune JM. Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus. Arthritis Res Ther. 2012; 14(3):R155. [DOI:10.1186/ar3895] [PMID] [PMCID]
- Abstract Viewed: 274 times
- PDF Downloaded: 101 times