Herpes Simplex Encephalitis: Successful Treatment with Acyclovir
Archives of Advances in Biosciences,
Vol. 10 No. 1 (2019),
12 January 2019
,
Page 56-58
https://doi.org/10.22037/jps.v10i1.19886
Abstract
Introduction: One of the most common causes of encephalitis is due to viral infections, such as herpes simplex. Traditionally, brain biopsy was required for the diagnosis of HSV encephalitis; however, here CSF PCR detection for herpes simplex encephalitis is reported which was successfully treated with Acyclovir.Case presentation:A 52 year old female patient was brought to emergency department with fever (400C), constipation, abdominal pain, fatigue, disorientation and agitation for the last two days. DNA extraction and Real Time PCR was performed on CSF sample for HSV-1/2 and HSV-1 was positive. Moreover, the brain MRI report showed left and basal temporal oppression, together with left and basal frontal pus. The patient was discharged after 20 days of hospitalization and treatment with acyclovir and normal physiological indexes and had a good clinical and neurologic outcome with resolution of all the symptoms.Conclusion:It is worthy to emphasize that despite the normal biochemical CSF, imaging results and PCR are proved evidence of HSV encephalitis.
- HSV
- encephalitis
- Acyclovir
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References
P G E Kennedy. Viral encephalitis: Causes, differential diagnosis, and management. J Neurol Neurosurg Psychiatry 2004;75(Suppl I):i10–i15. doi: 10.1136/jnnp.2003.034280.
Xu-Zheng Zuo, Wei-Ju Tang, Xiu-Ying Chen, Wen Huang. A review with comments on herpes simplex encephalitis in adults. Neuroimmunology and Neuroinflammation Print ISSN: 2347-8659; Online ISSN: 2349-6142. http://nnjournal.net/article/view/1584/1339.
Skelly MJ, Burger AA, Adekola O. Herpes simplex virus-1 encephalitis: a review of current disease management with three case reports. Antivir Chem Chemother. 2012;23(1):13–18
Michael J. Bradshaw1 and Arun Venkatesan Herpes Simplex Virus-1 Encephalitis in Adults: Pathophysiology, Diagnosis, and Management. Neurotherapeutics. 2016 Jul; 13(3): 493–508.
S Pirasath, G Selvaratnam, J Pradeepan. Herpes Simplex Encephalitis Mimicking as Cerebral Infarction. J Clin Case Rep 2016, 6:10.
Peter A. Abdelmalik, Timothy Ambrose, and Rodney Bell. Herpes Simplex Viral Encephalitis Masquerading as a Classic Left MCA Stroke. Case Reports in Neurological Medicine. 2015, Article ID 673724, 5 pages, http://dx.doi.org/10.1155/2015/673724.
Nidhi Kaeley, Sunil Bansal, Rohan Bhatia, Sohaib Ahmad. Herpes Simplex Encephalitis: An Uncommon Presentation. Journal of Clinical and Diagnostic Research. 2016; 10(5): 25-26.
Gautam Rawal, Sankalp Yadav, Umar Rasool Wani, and Alok Kumar Ambastha. HSV Encephalitis with Normal CSF — A Case Report with Review of Literature. J Clin Diagn Res. 2015 Dec; 9(12): 6–7.
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