Archives of Advances in Biosciences

Rodger MA. An update on thrombophilia and placenta mediated pregnancy complications: what should we tell our patients? Thromb Res. 2013;131 Suppl 1:S25-7.

Simcox LE, Ormesher L, Tower C, Greer IA. Thrombophilia and pregnancy complications. International journal of molecular sciences. 2015;16(12):28418-28.

Carrington B, Sacks G, Regan L. Recurrent miscarriage: pathophysiology and outcome. Current Opinion in Obstetrics and Gynecology. 2005;17(6):591-7.

Doyle NM, Monga M. Thromboembolic disease in pregnancy. Obstetrics and gynecology clinics of North America. 2004;31(2):319-44.

Rai R, Regan L. Recurrent miscarriage. The Lancet. 2006;368(9535):601-11.

Gawish GE. Molecular characterization of factor V leiden G1691A and prothrombin G20210A mutations in Saudi newborns with stroke. Biochemical genetics. 2011;49(9-10):601-10.

Kupferminc MJ, Rimon E, Many A, Sharon M, Lessing JB, Gamzu R. Low molecular weight heparin treatment during subsequent pregnancies of women with inherited thrombophilia and previous severe pregnancy complications. Journal of Maternal-Fetal and Neonatal Medicine. 2011;24(8):1042-5.

Pavlova E, Chemev T, Chemev A, Karagiozova Z. PREGNANCY AND ISSUES WITH INHERITED AND ACQUIRED THROMBOPHILIA. Journal of IMAB-Annula Proceeding. 2008:21-2.

Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. New England Journal of Medicine. 1999;340(1):9-13.

Kocher O, Cirovic C, Malynn E, Rowland CM, Bare LA, Young BA, et al. Obstetric Complications in Patients with Hereditary Thrombophilia Identified Using the LCx Microparticle Enzyme Immunoassay A Controlled Study of 5,000 Patients. American journal of clinical pathology. 2007;127(1):68-75.

Foka Z, Lambropoulos A, Saravelos H, Karas G, Karavida A, Agorastos T, et al. Factor V Leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages. Human Reproduction. 2000;15(2):458-62.

Bauduer F, Lacombe D. Factor V Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase 677T, and population genetics. Molecular genetics and metabolism. 2005;86(1):91-9.

Lucotte G, Mercier G. Population genetics of factor V Leiden in Europe. Blood Cells, Molecules, and Diseases. 2001;27(2):362-7.

Roozbeh N, Banihashemi F, Mehraban M, Abdi F. Potential role of Factor V Leiden mutation in adverse pregnancy outcomes: An updated systematic review. Biomedical Research and Therapy. 2017;4(12):1832-46.

Bafunno V, Margaglione M. Genetic basis of thrombosis. Clinical Chemistry and Laboratory Medicine. 2010;48:S41-S51.

Kujovich JL. Thrombophilia and pregnancy complications. American journal of obstetrics and gynecology. 2004;191(2):412-24.

Yamada H, Kato EH, Kobashi G, Ebina Y, Shimada S, Morikawa M, et al., editors. Recurrent pregnancy loss: etiology of thrombophilia. Seminars in thrombosis and hemostasis; 2000.

Rahimi Z, Vaisi-Raygani A, Mozafari H, Kharrazi H, Rezaei M, Nagel RL. Prevalence of factor V Leiden (G1691A) and prothrombin (G20210A) among Kurdish population from Western Iran. Journal of thrombosis and thrombolysis. 2008;25(3):280-3.

Behjati R, Modarressi MH, Jeddi-Tehrani M, Dokoohaki P, Ghasemi J, Zarnani AH, et al. Thrombophilic mutations in Iranian patients with infertility and recurrent spontaneous abortion. Annals of hematology. 2006;85(4):268-71.

Dahlbäck B. Advances in understanding pathogenic mechanisms of thrombophilic disorders. Blood. 2008;112(1):19-27.

Rosendorff A, Dorfman DM. Activated protein C resistance and factor V Leiden. Arch Pathol Lab Med. 2007;131(6):866-71.

Uvuz F, Kilic S, Yilmaz N, Tuncay G, Cakar E, Yuksel B, et al. Relationship between preterm labor and thrombophilic gene polymorphism: A prospective sequential cohort study. Gynecologic and obstetric investigation. 2008;68(4):234-8.

Bennett SA, Bagot CN, Arya R. Pregnancy loss and thrombophilia: the elusive link. British journal of haematology. 2012;157(5):529-42.

Jauniaux E, Farquharson RG, Christiansen OB, Exalto N. Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Human Reproduction. 2006;21(9):2216-22.

Serrano F, Lima ML, Lopes C, Almeida JP, Branco J. Factor V Leiden and prothrombin G20210A in Portuguese women with recurrent miscarriage: is it worthwhile to investigate? Archives of gynecology and obstetrics. 2011;284(5):1127-32.

Glueck CJ, Gogenini S, Munjal J, Tracy T, Pranikoff J, Wang P. Factor V Leiden mutation: a treatable etiology for sporadic and recurrent pregnancy loss. Fertility and sterility. 2008;89(2):410-6.

Parand A, Zolghadri J, Nezam M, Afrasiabi A, Haghpanah S, Karimi M. Inherited thrombophilia and recurrent pregnancy loss. Iranian Red Crescent medical journal. 2013;15(12).

Mohamed MA, El Moaty MA, El Kholy AF, Mohamed SA, Ali AI. Thrombophilic gene mutations in women with repeated spontaneous miscarriage. Genetic testing and molecular biomarkers. 2010;14(5):593-7.

Velez DR, Fortunato SJ, Thorsen P, Lombardi SJ, Williams SM, Menon R. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. PloS one. 2008;3(9):e3283.

Kovalevsky G, Gracia CR, Berlin JA, Sammel MD, Barnhart KT. Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis. Archives of internal medicine. 2004;164(5):558-63.

Lissalde‐Lavigne G, Fabbro‐Peray P, Cochery‐Nouvellon E, Mercier E, Ripart‐Neveu S, BALDUCCHI JP, et al. IN FOCUS: Factor V Leiden and prothrombin G20210A polymorphisms as risk factors for miscarriage during a first intended pregnancy: the matched case–control ‘NOHA first’study. Journal of Thrombosis and Haemostasis. 2005;3(10):2178-84.

Ardestani MT, Nodushan HH, Aflatoonian A, Ghasemi N, Sheikhha MH. Case control study of the factor V Leiden and factor II G20210A mutation frequency in women with recurrent pregnancy loss. Iranian Journal of Reproductive Medicine. 2013;11(1):61.

Mierla D, Szmal C, Neagos D, Cretu R, Stoian V, Jardan D. Association of Prothrombin (A20210G) and Factor V Leiden (A506G) with Recurrent Pregnancy Loss. Maedica. 2012;7(3):222.

Goodman CS, Coulam CB, Jeyendran RS, Acosta VA, Roussev R. Which thrombophilic gene mutations are risk factors for recurrent pregnancy loss? American Journal of Reproductive Immunology. 2006;56(4):230-6.

Colman RW. Are hemostasis and thrombosis two sides of the same coin? The Journal of experimental medicine. 2006;203(3):493-5.

Robertson L, Wu O, Langhorne P, Twaddle S, Clark P, Lowe G, et al. Thrombophilia in pregnancy: a systematic review. British journal of haematology. 2006;132(2):171-96.

Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. The Lancet. 2003;361(9361):901-8.

Di Micco P, Di Fiore R, Niglio A, Quaranta S, Angiolillo A, Cardillo G, et al. Different outcome of six homozygotes for prothrombin A20210A gene variant. J Transl Med. 2008;15:36.

Rai R, Shlebak A, Cohen H, Backos M, Holmes Z, Marriott K, et al. Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage. Human Reproduction. 2001;16(5):961-5.

Carp H, Salomon O, Seidman D, Dardik R, Rosenberg N, Inbal A. Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss. Human Reproduction. 2002;17(6):1633-7.

Bedoya G, Montoya P, García J, Soto I, Bourgeois S, Carvajal L, et al. Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate. Proceedings of the National Academy of Sciences. 2006;103(19):7234-9.

Carvajal-Carmona LG, Soto ID, Pineda N, Ortíz-Barrientos D, Duque C, Ospina-Duque J, et al. Strong Amerind/white sex bias and a possible Sephardic contribution among the founders of a population in northwest Colombia. The American Journal of Human Genetics. 2000;67(5):1287-95.

Cardona H, Castañeda SA, Cardona Maya W, Alvarez L, Gómez J, Gómez J, et al. Lack of association between recurrent pregnancy loss and inherited thrombophilia in a group of Colombian patients. Thrombosis. 2012;2012.

Ayadurai T, Muniandy S, Omar SZ. Thrombophilia investigation in Malaysian women with recurrent pregnancy loss. Journal of Obstetrics and Gynaecology Research. 2009;35(6):1061-8.

Daniela L, De Lisa E, Dellepiane M, Storch E, Attarian D, Ferrari A, et al. Trombofilia y pérdida recurrente de embarazo. Revista Médica del Uruguay. 2004;20(2):106-13.

Kazerooni T, Ghaffarpasand F, Asadi N, Dehkhoda Z, Dehghankhalili M, Kazerooni Y. Correlation between thrombophilia and recurrent pregnancy loss in patients with polycystic ovary syndrome: A comparative study. Journal of the Chinese Medical Association. 2013;76(5):282-8.

Dilley A, Benito C, Hooper W, Austin H, Miller C, El-Jamil M, et al. Mutations in the factor V, prothrombin and MTHFR genes are not risk factors for recurrent fetal loss. Journal of Maternal-Fetal and Neonatal Medicine. 2002;11(3):176-82.

Silver RM, Zhao Y, Spong CY, Sibai B, Wendel Jr G, Wenstrom K, et al. Prothrombin gene G20210A mutation and obstetric complications. Obstetrics and gynecology. 2010;115(1):14.

Coppens M, Folkeringa N, Teune M, Hamulyak K, Van Der Meer J, Prins M, et al. Outcome of the subsequent pregnancy after a first loss in women with the factor V Leiden or prothrombin 20210A mutations. Journal of Thrombosis and Haemostasis. 2007;5(7):1444-8.

Jivraj S, Rai R, Underwood J, Regan L. Genetic thrombophilic mutations among couples with recurrent miscarriage. Human Reproduction. 2006;21(5):1161-5.

Altintas A, Pasa S, Akdeniz N, Cil T, Yurt M, Ayyildiz O, et al. Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey. Annals of hematology. 2007;86(10):727-31.

Kist WJ, Janssen NG, Kalk JJ, Hague WM, Dekker GA, Vries Jd. Thrombophilias and adverse pregnancy outcome--A confounded problem! Thrombosis & Haemostasis. 2008;99(1):77.

Ivanov PD, Komsa-Penkova RS, Konova EI, Kovacheva KS, Simeonova MN, Popov JD. Association of inherited thrombophilia with embryonic and postembryonic recurrent pregnancy loss. Blood Coagulation & Fibrinolysis. 2009;20(2):134-40.

Norrie G, Farquharson RG, Greaves M. Screening and treatment for heritable thrombophilia in pregnancy failure: inconsistencies among UK early pregnancy units. British journal of haematology. 2009;144(2):241-4.

Reznikoff‐Etiévant M, Cayol V, Carbonne B, Robert A, Coulet F, Milliez J. Factor V Leiden and G20210A prothrombin mutations are risk factors for very early recurrent miscarriage. BJOG: An International Journal of Obstetrics & Gynaecology. 2001;108(12):1251-4.

Finan RR, Tamim H, Ameen G, Sharida HE, Rashid M, Almawi WY. Prevalence of factor V G1691A (factor V‐Leiden) and prothrombin G20210A gene mutations in a recurrent miscarriage population. American journal of hematology. 2002;71(4):300-5.

Bates SM, Greer IA, Pabinger I, Sofaer S, Hirsh J. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians evidence-based clinical practice guidelines. CHEST Journal. 2008;133(6_suppl):844S-86S.

Rodger MA, Paidas M, Claire M, Middeldorp S, Kahn S, Martinelli I, et al. Inherited thrombophilia and pregnancy complications revisited. Obstetrics & Gynecology. 2008;112(2, Part 1):320-4.

Pihusch R, Hiller E, Buchholz T, Rogenhofer N, Hasbargen U, Thaler CJ, et al. Thrombophilic gene mutations and recurrent spontaneous abortion: prothrombin mutation increases the risk in the first trimester. American Journal of Reproductive Immunology. 2001;46(2):124-31.

Idali F, Zareii S, Mohammad Zadeh A, Reihany Sabet F, AkbarzadehPasha Z, Khorram Khorshid HR, et al. Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase gene mutations in Iranian women with polycystic ovary syndrome. American Journal of Reproductive Immunology. 2012;68(5):400-7.

Rodger MA, Betancourt MT, Clark P, Lindqvist PG, Dizon-Townson D, Said J, et al. The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies. Plos medicine. 2010;7(6):e1000292.

Martinelli I, Legnani C, Bucciarelli P, Grandone E, De Stefano V, Mannucci PM. Risk of Pregnancy-related Venous Thrombosis in Carriers of Severe Inherited Thrombophilia*. Thromb Haemost. 2001;86(3):800-3.

Sood R. Thrombophilia and fetal loss: Lessons from gene targeting in mice. Thrombosis research. 2009;123:S79-S84.

Roqué H, Paidas MJ, Funai EF, Kuczynski E, Lockwood CJ. Maternal thrombophilias are not associated with early pregnancy loss. Thromb Haemost. 2004;91(2):290-5.

Göpel W, Ludwig M, Junge AK, Kohlmann T, Diedrich K, Möller J. Selection pressure for the factor-V-Leiden mutation and embryo implantation. The Lancet. 2001;358(9289):1238-9.

Qublan H, Malkawi H, Tahat Y, Areidah S, Nusair B, Khreisat B, et al. In-vitro fertilisation treatment: factors affecting its results and outcome. Journal of Obstetrics & Gynecology. 2005;25(7):689-93.

Qublan HS, Eid SS, Ababneh HA, Amarin ZO, Smadi AZ, Al-Khafaji FF, et al. Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. Human Reproduction. 2006;21(10):2694-8.

Vora S, Shetty S, Khare M, Ghosh K. Placental histomorphology in unexplained foetal loss with thrombophilia. The Indian journal of medical research. 2009;129(2):144-9.

Al Husseini NF, Rezk AY, Odah MM, El Rahman SM, Ali AI. Thrombophilic Genes Mutations in Women with Repeated In-Vitro Fertilization Failure. American Medical Journal. 2011;2(1):7.

Azem F, Many A, Yovel I, Amit A, Lessing JB, Kupferminc MJ. Increased rates of thrombophilia in women with repeated IVF failures. Human Reproduction. 2004;19(2):368-70.

Grandone E, Colaizzo D, Bue AL, Checola MG, Cittadini E, Margaglione M. Inherited thrombophilia and in vitro fertilization implantation failure. Fertility and sterility. 2001;76(1):201-2.

Abdi F, Aghaie Z, Rahnemaie FS, Alimoradi Z. A Systematic Review of First Trimester Biochemical and Molecular Predictive Tests for Preeclampsia. Current hypertension reviews. 2018;14(1):21-8.

Nourollahpour Shiadeh M, Behboodi Moghadam Z, Adam I, Saber V, Bagheri M, Rostami A. Human infectious diseases and risk of preeclampsia: an updated review of the literature. Infection. 2017;45(5):589-600.

Preston F, Rosendaal F, Walker I, Briet E, Berntorp E, Conard J, et al. Increased fetal loss in women with heritable thrombophilia. The Lancet. 1996;348(9032):913-6.

Soleimani F, Zaheri F, Abdi F. Long-Term Neurodevelopmental Outcomes After Preterm Birth. Iranian Red Crescent Medical Journal. 2014;16(6):e17965.

Soleimani F, Zaheri F, Abdi F. Developmental outcome of low birth-weight and preterm newborns: a re-view of current evidence. Tehran University Medical Journal. 2013;71(9):551-61.

Resch B, Gallistl S, Kutschera J, Mannhalter C, Muntean W, Mueller WD. Thrombophilic polymorphisms–factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations–and preterm birth. Wiener Klinische Wochenschrift. 2004;116(17-18):622-6.

Göpel W, Kim D, Gortner L. Prothrombotic mutations as a risk factor for preterm birth. The Lancet. 1999;353(9162):1411-2.

von Kries R, Junker R, Oberle D, Kosch A, Nowak-Gottl U. Foetal growth restriction in children with prothrombotic risk factors. THROMBOSIS AND HAEMOSTASIS-STUTTGART-. 2001;86(4):1012-6.

Infante-Rivard C, Rivard G-E, Yotov WV, Génin E, Guiguet M, Weinberg C, et al. Absence of association of thrombophilia polymorphisms with intrauterine growth restriction. New England Journal of Medicine. 2002;347(1):19-25.

Watzke HH. Clinical significance of gene-diagnosis for defects in coagulation factors and inhibitors. Wiener Klinische Wochenschrift. 2003;115(13-14):475-81.

Hammerová L, Chabada J, Drobný J, Bátorová A. Factor V Leiden mutation and its impact on pregnancy complications. Acta Medica (Hradec Kralove). 2011;54:117-21.

Empson M, Lassere M, Craig J, Scott J. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant (Review). 2007.

Tormene D, Grandone E, De Stefano V, Tosetto A, Palareti G, Margaglione M, et al. Obstetric complications and pregnancy-related venous thromboembolism: the effect of low-molecular-weight heparin on their prevention in carriers of factor V Leiden or prothrombin G20210A mutation. Thrombosis and haemostasis. 2012;107(3):477.

Lepercq J, Conard J, Borel‐Derlon A, Darmon JY, Boudignat O, Francoual C, et al. Venous thromboembolism during pregnancy: a retrospective study of enoxaparin safety in 624 pregnancies. BJOG: An International Journal of Obstetrics & Gynaecology. 2001;108(11):1134-40.

Middeldorp S. Anticoagulation in pregnancy complications. Hematology Am Soc Hematol Educ Program. 2014;2014(1):393-9.