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Risk of Outbreak Omicron Virus by Increasing the Number of Mutations in the Receptor Binding Domain (RBD) Increasing number of mutations in RBD in Omicron outbreak

  • Mehdi Pooladi
  • Soheila Karani

Trends in Peptide and Protein Sciences, Vol. 7 (2022), , Page 1-3 (e1)
https://doi.org/10.22037/tpps.v7i.37447 Published 7 March 2022

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Abstract

HIGHLIGHTS


  • Rapid spread of Omicron variant is a serious challenge.

  • More than 50 mutations have occurred in Omicron variant.

  • The mutations have caused the RBD structure to undergo significant changes

Keywords:
  • Mutation
  • Omicron
  • Receptor binding domain (RBD)
  • Spike protein
  • PDF

How to Cite

1.
Pooladi M, Karani S. Risk of Outbreak Omicron Virus by Increasing the Number of Mutations in the Receptor Binding Domain (RBD): Increasing number of mutations in RBD in Omicron outbreak. Trends Pept. Protein Sci. [Internet]. 2022Mar.7 [cited 2022Jun.29];7:1-3 (e1). Available from: https://journals.sbmu.ac.ir/protein/article/view/37447
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References

Cohen, J. (2021). ″Omicron sparks a vaccine strategy debate.″ Science, 374(6575):1561-1562. DOI: 10.1126/science.acz9879.

Cross, R. (2021). ″Omicron puts scientists on red alert.″ C&EN Global Enterprise, 99 (44): 6-6. DOI: 10.1021/cen-09944-leadcon.

Graham, F. (2021). ″Daily briefing: Omicron might weaken vaccine protection.″ Nature Briefing. DOI: 10.1038/d41586-021-03689-8.

Hastie, K.M., Li, H., Bedinger, D., Schendel, S.L., Dennison, S.M., Li, K. and E.O. Saphire, (2021). ″Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study.″ Science, 374(6566): 472-478. DOI: 10.1126/science.abh2315.

Karim, S.S.A. and Q.A. Karim, (2021). ″Omicron SARS-CoV-2 variant: A new chapter in the COVID-19 pandemic.″ The Lancet, 398(10317): 2126-2128. DOI: 10.1016/S0140-6736(21)02758-6.

Kim, S., Nguyen, T. T., Taitt, A. S., Jhun, H., Park, H. Y., Kim, S. H. and S. Kim, (2021). ″SARS-CoV-2 Omicron mutation is faster than the chase: Multiple mutations on Spike/ACE2 interaction residues.″ Immune Network, 21(6): e38. DOI: 10.4110/in.2021.21.e38.

Kumar, S., Thambiraja, T.S., Karuppanan, K. and G. Subramaniam, (2021). ″Omicron and Delta variant of SARS‐CoV‐2: A comparative computational study of spike protein.″ Journal of Medical Virology, 2021: 1–9. DOI: 10.1002/jmv.27526.

Li, A., Maier, A., Carter, M. and T Hugh Guan, (2021). ″Omicron and S‐gene target failure cases in the highest COVID‐19 case rate region in Canada - December 2021.″ Journal of Medical Virology. 2022:1-3. DOI: 10.1002/jmv.27562.

Meo, S.A., Meo, A.S., Al-Jassir, F.F. and D.C. Klonoff, (2021). ″Omicron SARS-CoV-2 new variant: global prevalence and biological and clinical characteristics. European Review for Medical and Pharmacological Sciences, 25(24): 8012-8018. DOI: 10.26355/eurrev_202112_27652.

Pooladi, M., Entezari, M., Hashemi, M., Bahonar, A., Hushmandi, K. and M. Raei, (2020). Investigating the efficient management of different countries in the COVID-19 pandemic.″ Journal of Marine Medicine, 2(1):18-25. DOI :10.30491/2.1.3.

Pooladi, M., Hushmandi, K. and M. Entezari, (2021). ″Risk of increased expression of ACE2 membrane protein in patients with hypertension: Review of COVID-19.″ Archives of Advances in Biosciences, 12(1): 52-64. DOI.org/10.22037/aab.v12i1.30521.

Rath, S.L., Padhi, A.K. and N. Mandal, (2022). ″Scanning the RBD-ACE2 molecular interactions in Omicron variant.″ Biochemical and Biophysical Research Communications, 592:18-23. DOI: 10.1016/j.bbrc.2022.01.006.

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All open-access articles of TPPS are distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Journal Name:

Trends in Peptide and Protein Sciences (TPPS)

Journal Abbreviation:

Trends Pept. Protein Sci.

eISSN:

2538-2446

 

 

 

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