Restoration of Harmane Induced Memory Consolidation Deficit by Alpha-lipoic Acid in Male Mice
Archives of Advances in Biosciences,
Vol. 13 No. 1 (2022),
1 January 2022
,
Page 1-6
https://doi.org/10.22037/aab.v13i2.38259
Abstract
Introduction: there has been a growing number of publications focusing on the effect of beta-carbolines (e.g., harmane) on cognitive behaviors such as different stages of memory formation process. Moreover, several studies have stated that Alpha-lipoic acid (ALA) induces some molecular pathways effects including antioxidant effect and reduction of inflammation process. Thus, in the lines that follow, the question of whether ALA could alter memory consolidation deficit caused by harmane in the male NMRI mice will be addressed.
Materials and Methods: The data for this study were collected by step-down inhibitory avoidance task with one trial protocol for evaluation of memory consolidation. The ALA (35 mg/kg) was injected intraperitoneally immediately after training followed by subthreshold and effective doses of harmane (2.5, 5 and 10 mg/kg) with 15-minute interval period.
Results: The results show that post-training injection of the highest dose of harmane (10 mg/kg) lowers step-down latency, indicating the amnesia induced by harmane (P<.001). In addition, similar injection of subthreshold dose of ALA (35 mg/kg), 15 minutes before injection of subthreshold and effective doses of harmane, restores step-down latency caused by higher dose of harmane (P<.001) without its effect on the responses induced by subthreshold doses of harmane, indicating benefit effect of ALA on amnesia induced by harmane.
Conclusion: An implication of this study is the possibility that ALA can reverse the amnesia induced by harmane. Therefore, future studies on this topic such as molecular mechanisms are recommended.
- Alpha-lipoic acid, Beta-carboline, Memory consolidation, Mice
How to Cite
References
Ferraz CAA, de Oliveira Junior RG, de Oliveira AP, Groult H, Beaugeard L, Picot L, et al. Complexation with beta-cyclodextrin enhances apoptosis-mediated cytotoxic effect of harman in chemoresistant BRAF-mutated melanoma cells. Eur J Pharm Sci. 2020; 150:105353. [DOI:10.1016/j.ejps. 2020.105353] [PMID]
Pfau W, Skog K. Exposure to beta-carbolines norharman and harman. J Chromatogr B Analyt Technol Biomed Life Sci. 2004; 802(1):115-26. [DOI:10.1016/j.jchromb.2003.10.044] [PMID]
Herath W, Mikell JR, Ferreira D, Khan IA. Microbial metabolites of harman alkaloids. Chem Pharm Bull (Tokyo). 2003; 51(6):646-8. [DOI:10.1248/cpb.51.646] [PMID]
Aassila H, Bourguet-Kondracki ML, Rifai S, Fassouane A, Guyot M. Identification of harman as the antibiotic compound produced by a tunicate-associated bacterium. Mar Biotechnol (NY). 2003; 5(2):163-6. [DOI:10.1007/s10126-002-0060-7]
Celikyurt IK, Utkan T, Gocmez SS, Hudson A, Aricioglu F. Effect of harmane, an endogenous beta-carboline, on learning and memory in rats. Pharmacol Biochem Behav. 2013; 103(3):666-71. [DOI;10.1016/j.pbb.2012.10.011] [PMID]
Nasehi M, Ghadimi F, Khakpai F, Zarrindast MR. Interaction between harmane, a class of beta-carboline alkaloids, and the CA1 serotonergic system in modulation of memory acquisition. Neurosci Res. 2017; 122:17-24. [DOI:10.1016/j.neures. 2017.03.011] [PMID]
Nasehi M, Hasanvand S, Khakpai F, Zarrindast MR. The effect of CA1 dopaminergic system on amnesia induced by harmane in mice. Acta Neurol Belg. 2019; 119(3):369-77. [DOI:10.1007/s13760-018-0966-0] [PMID]
Nasehi M, Mashaghi E, Khakpai F, Zarrindast MR. Suggesting a possible role of CA1 histaminergic system in harmane-induced amnesia. Neurosci Lett. 2013; 556:5-9. [DOI:10.1016/j.neulet.2013.09.066] [PMID]
Nasehi M, Piri M, Abdollahian M, Zarrindast MR. Involvement of nitrergic system of CA1in harmane induced learning and memory deficits. Physiol Behav. 2013; 109:23-32. [DOI:10.1016/j.physbeh.2012.10.006] [PMID]
Goodwin AK, Lantz-McPeak SM, Robinson BL, Law CD, Ali SF, Ferguson SA. Effects of adolescent treatment with nicotine, harmane, or norharmane in male Sprague-Dawley rats. Neurotoxicol Teratol. 2015; 47:25-35. [DOI:10.1016/j. ntt.2014.10.005]
Staykov H, Lazarova M, Hassanova Y, Stefanova M, Tancheva L, Nikolov R. Neuromodulatory mechanisms of a memory loss-preventive effect of alpha-lipoic acid in an experimental rat model of dementia. J Mol Neurosci. 2022; 72(5):1018-25. [DOI:10.1007/s12031-022-01979-y] [PMID]
Zarini-Gakiye E, Vaezi G, Parivar K, Sanadgol N. Age and dose-dependent effects of alpha-lipoic acid on human microtubule- associated protein tau-induced endoplasmic reticulum unfolded protein response: implications for Alzheimer's Disease. CNS Neurol Disord Drug Targets. 2021; 20(5):451-64. [DOI:10.2174/1871527320666210126114442] [PMID]
Zarini-Gakiye E, Sanadgol N, Parivar K, Vaezi G. Alpha-lipoic acid ameliorates tauopathy-induced oxidative stress, apoptosis, and behavioral deficits through the balance of DIAP1/DrICE ratio and redox homeostasis: Age is a determinant factor. Metab Brain Dis. 2021; 36(4):669-83. [DOI:10.1007/s11011-021-00679-7] [PMID]
Wu D, Liu H, Liu Y, Wei W, Sun Q, Wen D, et al. Protective effect of alpha-lipoic acid on bisphenol A-induced learning and memory impairment in developing mice: nNOS and keap1/Nrf2 pathway. Food Chem Toxicol. 2021; 154:112307. [DOI:10.1016/j.fct.2021.112307] [PMID]
Memudu AE and Adewumi AE. Alpha lipoic acid ameliorates scopolamine induced memory deficit and neurodegeneration in the cerebello-hippocampal cortex. Metab Brain Dis. 2021; 36(7):1729-45. [DOI:10.1007/s11011-021-00720-9]
Lewis JE, Poles J, Shaw DP, Karhu E, Khan SA, Lyons AE, et al. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. J Clin Transl Res. 2021; 7(4):575-620. [PMID] [PMCID]
Ghafour-Boroujerdi E, Rahmani S, Sanadgol N, Baeeri M, Hassani S. Investigation of alpha-lipoic acid effect on memory impairment considering strain-dependent differences in mice. Life Sci. 2021; 281:119766. [DOI:10.1016/j.lfs.2021.119766] [PMID]
Mahboob A, Farhat SM, Iqbal G, Babar MM, Zaidi NU, Nabavi SM, et al. Alpha-lipoic acid-mediated activation of muscarinic receptors improves hippocampus- and amygdala-dependent memory. Brain Res Bull. 2016; 122:19-28. [DOI:10.1016/j.brainresbull.2016.02.014] [PMID]
Nasehi M, Sharifi S, Zarrindast MR. Involvement of the cholinergic system of CA1 on harmane-induced amnesia in the step-down passive avoidance test. J Psychopharmacol. 2012; 26(8):1151-61. [DOI:10.1177/0269881111421972]
Nasehi M, Piri M, Nouri M, Farzin D, Nayer-Nouri T, Zarrindast MR. Involvement of dopamine D1/D2 receptors on harmane-induced amnesia in the step-down passive avoidance test. Eur J Pharmacol. 2010; 634(1-3):77-83. [DOI:10. 1016/j.ejphar.2010.02.027] [PMID]
Nasehi M, Jamshidi-Mehr M, Khakpai F, Zarrindast MR. Possible involvement of CA1 5-HT1B/1D and 5-HT2A/2B/2C receptors in harmaline-induced amnesia. Pharmacol Biochem Behav. 2014; 125:70-7. [DOI:10.1016/j.pbb.2014.08.007] [PMID]
Smith KL, Ford GK, Jessop DS, and Finn DP. Behavioural, neurochemical and neuroendocrine effects of the endogenous beta-carboline harmane in fear-conditioned rats. J Psychopharmacol. 2013; 27(2):162-70. [DOI:10.1177/026988 1112460108] [PMID]
Moura DJ, Rorig C, Vieira DL, Henriques JA, Roesler R, Saffi J, et al. Effects of beta-carboline alkaloids on the object recognition task in mice. Life Sci. 2006; 79(22):2099-104. [DOI:10.1016/j.lfs.2006.07.004] [PMID]
Abdul Sater Z, Cero C, Pierce AE, Lea HJ, Abdul Sater H, Zhu KY, et al. Combining a beta3 adrenergic receptor agonist with alpha-lipoic acid reduces inflammation in male mice with diet-induced obesity. Obesity. 2022; 30(1):153-64. [DOI:10.1002/ oby.23309] [PMID]
Di Tucci C, Galati G, Mattei G, Bonanni V, Capri O, D'Amelio R, et al. The role of alpha lipoic acid in female and male infertility: a systematic review. Gynecol Endocrinol. 2021; 37(6):497-505. [DOI:10.1080/09513590.2020.1843619] [PMID]
Jeffrey S, Isaac Samraj P, Sundara Raj B. Therapeutic Benefits of Alpha-Lipoic Acid Supplementation in Diabetes Mellitus: A Narrative Review. J Diet Suppl. 2021; 19(4):1-21. [DOI:10.1080/19390211.2021.2020387] [PMID]
Jeffrey S, Samraj PI, Raj BS. The Role of Alpha-lipoic Acid Supplementation in the Prevention of Diabetes Complications: A Comprehensive Review of Clinical Trials. Curr Diabetes Rev. 2021; 17(9):011821190404. [DOI:10.2174/1573399817 666210118145550] [PMID]
Kelishadi MR, Naeini AA, Khorvash F, Askari G, Heidari Z. The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines. Sci Rep. 2022; 12(1):1-12. [DOI:10.1038/s41598-021-04397-z] [PMID] [PMCID]
Ko CY, Xu JH, Lo YM, Tu RS, Wu JS, Huang WC, et al. Alleviative Effect of Alpha-Lipoic Acid on Cognitive Impairment in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Rats. Front Aging Neurosci. 2021; 13:1-12. [DOI:10.3389/fnagi.2021.774477] [PMID] [PMCID]
Maciejczyk M, Zebrowska E, Nesterowicz M, Zendzian-Piotrowska M, Zalewska A. Alpha-lipoic acid strengthens the antioxidant barrier and reduces oxidative, nitrosative, and glycative damage, as well as inhibits inflammation and apoptosis in the hypothalamus but not in the cerebral cortex of insulin-resistant rats. Oxid Med Cell Longev. 2022; 2022:1-21. [DOI:10.1155/2022/7450514]
Najafi N, Mehri S, Ghasemzadeh Rahbardar M, and Hosseinzadeh H. Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review. Phytother Res. 2022; 36(6):2300-23. [DOI:10.1002/ptr.7406] [PMID]
Pei X, Hu F, Luo F, Huang X, Li X, Xing S, et al. The neuroprotective effects of alpha-lipoic acid on an experimental model of Alzheimer's disease in PC12 cells. J Appl Toxicol. 2022; 42(2):285-94. [DOI:10.1002/jat.4213] [PMID]
- Abstract Viewed: 126 times
- PDF Downloaded: 42 times
- MP3 Downloaded: 10 times