Journal of Otorhinolaryngology and Facial Plastic Surgery

Vol. 6 No. 1 (2020)

Trehalose increase proliferation and decrease apoptosis in hair cells induced by Hydrogen peroxides

Journal of Otorhinolaryngology and Facial Plastic Surgery, Vol. 6 No. 1 (2020), 12 September 2020 , Page 1-5
https://doi.org/10.22037/orlfps.v6i1.32486

Abstract

BACKGROUND: Hydrogen peroxide (H2O2) a key reactive oxygen species, which is made through redox procedure, can induce oxidative damage to several biological macromolecules and play critical role in neurodegenerative diseases.

Aim: The current study examined the neuroprotective effect of Trehalose on hair cells death induced by H2O2.

Material and method: Hair cells were co-treated by Trehalose and H2O2. The effects of Trehalose on BAX/BCL2 expression ratio and cell viability were assessed by Real time PCR and MTT assay, respectively.

 Result:  The results of Real time PCR and MTT assay indicated that H2O2 induce cell death, and Trehalose have neuroprotective effect and decreases cell death.

Conclusion: Our data showed that Trehalose has the protective effect on hair cells death induced by H202

Keywords:
  • Hair cells, H2O2, Trehalose, BAX/BCL2 expression

How to Cite

Abbaszadeh , H. A. ., Shirazi Tehrani, A. ., Niknazar, S., & Khoshsirat, S. . (2020). Trehalose increase proliferation and decrease apoptosis in hair cells induced by Hydrogen peroxides. Journal of Otorhinolaryngology and Facial Plastic Surgery, 6(1), 1–5. https://doi.org/10.22037/orlfps.v6i1.32486

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