Chitosan-based Scaffolds, Suitable Structures for Wound Healing Dressing: A Short Review
Regeneration, Reconstruction & Restoration (Triple R),
Vol. 5 (2020),
24 March 2020
,
Page e11
https://doi.org/10.22037/rrr.v5i1.31130
Abstract
Introduction: Different kinds of substances has been used for wound dressing, however, some disadvantages such as unsatisfactory mechanical stability, poor flexibility, severe shrinkage, low porosity, hard separation from the wound site, and non-antibacterial activity, has been reported. Over the last two decades, much effort has been made to find suitable biopolymer materials for wound healing applications. Chitosan has revealed various biological properties like biodegradable, biocompatible, non-toxic and non-allergenic, antibacterial effects thus can be used for the production of biofilms and nano-scaffolds. The poor solubility and thermal properties of chitosan restrict its widespread uses, but this polysaccharide is highly compatible with other biopolymers, and researchers are using this property to improve the limitations of chitosan and produce various types of chitosan-based hybrids materials. The purpose of this study is to provide an overview of various chitosan-based nanoscaffolds as wound healing dressings.
Materials and Methods: This narrative review was performed using ISI Web of Science, PubMed, SID, Scholar, Scopus, and Science Direct and articles published up to Jan 2020 were included. The keywords of chitosan, chitosan-based scaffolds, chitosan-based composite, and wound dressing were used.
Results: Many researches have been accomplished to obtain chitosan-based scaffolds, including the construction of chitosan based blends and composite scaffolds and etc. The results of most of these researches showed positive effects of chitosan, and its nanocomposite scaffolds/biofilms in blood clotting, activated platelet activity, facilitated tissue regeneration and wound healing process. Conclusion: The use of chitosan-based scaffolds is effective in biological dressings and wound healing. Futuristic and innovative approaches in chitosan derivatives and nanocomposites can lead to the preparation of suitable co-polymers and the production of wound dressings with the desired properties. the authors hope that this review will help for researchers.
- Chitosan
- Chitosan-based scaffolds
- Chitosan-based composite
- Biopolymer
- Wound dressing
How to Cite
References
Zarrintaj P, Moghaddam AS, Manouchehri S, Atoufi Z, Amiri A, Amirkhani MA, et al. Can regenerative medicine and nanotechnology combine to heal wounds? The search for the ideal wound dressing. Nanomedicine (Lond). 2017;12(19):2403-22.
Abdelrahman T, Newton H. Wound dressings: Principles and practice. Surgery (oxford). 2011;29:491-5.
Miguel S, Moreira A, Correia I. Chitosan based-asymmetric membranes for wound healing: A review. International Journal of Biological Macromolecules. 2019;127.
Seyyed Tabaei SJ, Rahimi M, Akbaribazm M, Ziai SA, Sadri M, Shahrokhi SR, et al. Chitosan-based nano-scaffolds as antileishmanial wound dressing in BALB/c mice treatment: Characterization and design of tissue regeneration. Iranian Journal of Basic Medical Sciences. 2020;23(6):788-99.
Boateng JS, Matthews KH, Stevens HN, Eccleston GM. Wound healing dressings and drug delivery systems: a review. Journal of pharmaceutical sciences. 2008;97(8):2892-923.
Sarabahi S. Recent advances in topical wound care. Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India. 2012;45:379-87.
Ong S-Y, Wu J, Moochhala S, Tan M, Lu J. Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties. Biomaterials. 2008;29:4323-32.
Paul W, Sharma C. Chitosan and Alginate Wound Dressings: A Short Review. Trends in Biomaterials and Artificial Organs. 2004;18.
Berger J, Reist M, Mayer J, Felt O, Gurny R. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik eV. 2004;57:35-52.
Branski L, Gauglitz G, Herndon D, Jeschke M. A review of gene and stem cell therapy in cutaneous wound healing. Burns : journal of the International Society for Burn Injuries. 2008;35:171-80.
K S, Kim H, P.s S, Chun B-S, Kang HW. Fabrication of multifunctional chitosan-based nanocomposite film with rapid healing and antibacterial effect for wound management. International Journal of Biological Macromolecules. 2018;118.
Baghaie S, Khorasani MT, Zarrabi A, Moshtaghian J. Wound healing properties of PVA/ starch /chitosan hydrogel membranes with nano Zinc oxide as antibacterial wound dressing material. Journal of Biomaterials Science, Polymer Edition. 2017;28:1-40.
Burkatovskaya M, Castano AP, Demidova-Rice TN, Tegos GP, Hamblin MR. Effect of chitosan acetate bandage on wound healing in infected and noninfected wounds in mice. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2008;16(3):425-31.
Ishihara M, Nakanishi K, Ono K, Sato M, Kikuchi M, Saito Y, et al. Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process. Biomaterials. 2002;23(3):833-40.
Lin J, Li C, Zhao Y, Hu J, Zhang LM. Co-electrospun nanofibrous membranes of collagen and zein for wound healing. ACS Appl Mater Interfaces. 2012;4(2):1050-7.
Charernsriwilaiwat N, Opanasopit P, Rojanarata T, Ngawhirunpat T. Lysozyme-loaded, electrospun chitosan-based nanofiber mats for wound healing. International journal of pharmaceutics. 2012;427(2):379-84.
Luo Y, Luo G, Gelinsky M, Huang P, Ruan C. 3D bioprinting scaffold using alginate/polyvinyl alcohol bioinks. Materials Letters. 2017;189:295-8.
Sudhakar YN, Selvakumar M, Bhat DK. Chapter 2 - Methods of Preparation of Biopolymer Electrolytes. In: Sudhakar YN, Selvakumar M, Bhat DK, editors. Biopolymer Electrolytes: Elsevier; 2018. p. 35-52.
Fong D, Hoemann CD. Chitosan immunomodulatory properties: perspectives on the impact of structural properties and dosage. Future science OA. 2018;4(1):Fso225.
Ge J, Cui Y, Yan Y, Jiang W. The Effect of Structure on Pervaporation of Chitosan Membrane. Journal of Membrane Science - J MEMBRANE SCI. 2000;165:75-81.
Hu Y, Jiang X, Ding Y, Ge H, Yuan Y, Yang C. Synthesis and characterization of chitosan-poly(acrylic acid) nanoparticles. Biomaterials. 2002;23(15):3193-201.
Shi XY, Tan TW. Preparation of chitosan/ethylcellulose complex microcapsule and its application in controlled release of vitamin D2. Biomaterials. 2002;23(23):4469-73.
Madhumathi K, Shalumon KT, Rani VV, Tamura H, Furuike T, Selvamurugan N, et al. Wet chemical synthesis of chitosan hydrogel-hydroxyapatite composite membranes for tissue engineering applications. Int J Biol Macromol. 2009;45(1):12-5.
Li X, Kong X, Zhang Z, Nan K, Li L, Wang X, et al. Cytotoxicity and biocompatibility evaluation of N,O-carboxymethyl chitosan/oxidized alginate hydrogel for drug delivery application. Int J Biol Macromol. 2012;50(5):1299-305.
Luca L, Rougemont AL, Walpoth BH, Boure L, Tami A, Anderson JM, et al. Injectable rhBMP-2-loaded chitosan hydrogel composite: osteoinduction at ectopic site and in segmental long bone defect. Journal of biomedical materials research Part A. 2011;96(1):66-74.
Archana D, Dutta J, Dutta PK. Evaluation of chitosan nano dressing for wound healing: characterization, in vitro and in vivo studies. Int J Biol Macromol. 2013;57:193-203.
Dai T, Tegos G, Burkatovskaya M, Castano A, Hamblin M. Chitosan Acetate Bandage as a Topical Antimicrobial Dressing for Infected Burns. Antimicrobial agents and chemotherapy. 2008;53:393-400.
Ahmed S, Ikram S. Chitosan Based Scaffolds and Their Applications in Wound Healing. Achievements in the Life Sciences. 2016;10(1):27-37.
Patrulea V, Ostafe V, Borchard G, Jordan O. Chitosan as a starting material for wound healing applications. Eur J Pharm Biopharm. 2015;97(Pt B):417-26.
Ahmed S, Ahmad M, Swami BL, Ikram S. A review on plants extract mediated synthesis of silver nanoparticles for antimicrobial applications: A green expertise. Journal of Advanced Research. 2016;7(1):17-28.
Mattioli-Belmonte M, Zizzi A, Lucarini G, Giantomassi F, Biagini G, Tucci G, et al. Chitin Nanofibrils Linked to Chitosan Glycolate as Spray, Gel, and Gauze Preparations for Wound Repair. Journal of Bioactive and Compatible Polymers. 2007;22(5):525-38.
Liu H, Wang C, Li C, Qin Y, Wang Z, Yang F, et al. A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing. RSC Advances. 2018;8:7533-49.
Khan MA, Mujahid M. A review on recent advances in chitosan based composite for hemostatic dressings. International Journal of Biological Macromolecules. 2019;124:138-47.
Jayakumar R, Prabaharan M, Sudheesh Kumar PT, Nair SV, Tamura H. Biomaterials based on chitin and chitosan in wound dressing applications. Biotechnology advances. 2011;29(3):322-37.
Jayakumar R, Prabaharan M, Nair SV, Tamura H. Novel chitin and chitosan nanofibers in biomedical applications. Biotechnology advances. 2010;28(1):142-50.
Adeli H, Khorasani MT, Parvazinia M. Wound dressing based on electrospun PVA/chitosan/starch nanofibrous mats: Fabrication, antibacterial and cytocompatibility evaluation and in vitro healing assay. Int J Biol Macromol. 2019;122:238-54.
Garg T, Singh O, Arora S, Rayasa M. Scaffold: A Novel Carrier for Cell and Drug Delivery. Critical reviews in therapeutic drug carrier systems. 2012;29:1-63.
Vishal P. Scaffolds: Porous Scaffold for Modulated Drug Delivery. Austin Therapeutics. 2016;3:1027.
Jawaid M, Abdul Khalil HPS. Cellulosic/synthetic fibre reinforced polymer hybrid composites: A review. Carbohydrate polymers. 2011;86(1):1-18.
Huang Y, Onyeri S, Siewe M, Moshfeghian A, Madihally SV. In vitro characterization of chitosan–gelatin scaffolds for tissue engineering. Biomaterials. 2005;26(36):7616-27.
Anderl J, Beckstead B, Brown C, Hoffman A, Giachelli C. Adhesive protein interactions with chitosan: Consequences for valve endothelial cell growth on tissue-engineering materials. Journal of biomedical materials research Part A. 2003;67:538-47.
Ragetly G, Griffon D, Lee H, Chung Y. Effect of collagen II coating on mesenchymal stem cell adhesion on chitosan and on reacetylated chitosan fibrous scaffolds. Journal of materials science Materials in medicine. 2010;21:2479-90.
Cuy JL, Beckstead BL, Brown CD, Hoffman AS, Giachelli CM. Adhesive protein interactions with chitosan: consequences for valve endothelial cell growth on tissue-engineering materials. Journal of biomedical materials research Part A. 2003;67(2):538-47.
Mingyu C, Kai G, Jiamou L, Yandao G, Nanming Z, Xiufang Z. Surface modification and characterization of chitosan film blended with poly-L-lysine. Journal of biomaterials applications. 2004;19(1):59-75.
Zhang M, Li XH, Gong YD, Zhao NM, Zhang XF. Properties and biocompatibility of chitosan films modified by blending with PEG. Biomaterials. 2002;23(13):2641-8.
Zhang J, Nie J, Zhang Q, Li Y, Wang Z, Hu Q. Preparation and characterization of bionic bone structure chitosan/hydroxyapatite scaffold for bone tissue engineering. Journal of biomaterials science Polymer edition. 2014;25(1):61-74.
Yamane S, Iwasaki N, Majima T, Funakoshi T, Masuko T, Harada K, et al. Feasibility of chitosan-based hyaluronic acid hybrid biomaterial for a novel scaffold in cartilage tissue engineering. Biomaterials. 2005;26(6):611-9.
Gomes SR, Rodrigues G, Martins GG, Roberto MA, Mafra M, Henriques CM, et al. In vitro and in vivo evaluation of electrospun nanofibers of PCL, chitosan and gelatin: a comparative study. Materials science & engineering C, Materials for biological applications. 2015;46:348-58.
Elhefian E. Chitosan-Based Polymer Blends: Current Status and Applications. Journal- Chemical Society of Pakistan. 2014;36:11-27.
Miguel SP, Ribeiro MP, Brancal H, Coutinho P, Correia IJ. Thermoresponsive chitosan-agarose hydrogel for skin regeneration. Carbohydrate polymers. 2014;111:366-73.
Anisha BS, Biswas R, Chennazhi KP, Jayakumar R. Chitosan-hyaluronic acid/nano silver composite sponges for drug resistant bacteria infected diabetic wounds. Int J Biol Macromol. 2013;62:310-20.
Li D, Diao J, Zhang J, Liu J. Fabrication of New Chitosan-Based Composite Sponge Containing Silver Nanoparticles and Its Antibacterial Properties for Wound Dressing. Journal of nanoscience and nanotechnology. 2011;11:4733-8.
Li D, Diao J, Zhang J, Liu J. Fabrication of new chitosan-based composite sponge containing silver nanoparticles and its antibacterial properties for wound dressing. J Nanosci Nanotechnol. 2011;11(6):4733-8.
VandeVord PJ, Matthew HW, DeSilva SP, Mayton L, Wu B, Wooley PH. Evaluation of the biocompatibility of a chitosan scaffold in mice. Journal of biomedical materials research. 2002;59(3):585-90.
Silva SS, Popa EG, Gomes ME, Cerqueira M, Marques AP, Caridade SG, et al. An investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine. Acta biomaterialia. 2013;9(6):6790-7.
Szekalska M, Puciłowska A, Szymańska E, Ciosek P, Winnicka K. Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications. International Journal of Polymer Science. 2016;2016:7697031.
Yan XL, Khor E, Lim L. Chitosan-alginate films prepared with chitosans of different molecular weights. Journal of biomedical materials research. 2001;58:358-65.
Meng X, Tian F, Yang J, He C-N, Xing N, Li F. Chitosan and alginate polyelectrolyte complex membranes and their properties for wound dressing application. Journal of materials science Materials in medicine. 2010;21:1751-9.
Yan X, Khor E, Lim L. PEC Films Prepared from Chitosan-Alginate Coacervates. Chemical & pharmaceutical bulletin. 2000;48:941-6.
Momin M, Kurhade S, Khanekar P, Mhatre S. Novel biodegradable hydrogel sponge containing curcumin and honey for wound healing. Journal of Wound Care. 2016;25:364-72.
Tran C, Duri S, Harkins A. Recyclable synthesis, characterization, and antimicrobial activity of chitosan-based polysaccharide composite materials. Journal of biomedical materials research Part A. 2013;101A.
Harkins A, Duri S, Kloth L, Tran C. Chitosan-cellulose composite for wound dressing material. Part 2. Antimicrobial activity, blood absorption ability, and biocompatibility. Journal of biomedical materials research Part B, Applied biomaterials. 2014;102.
H.P.S AK, Saurabh C, Adnan A, Fazita M, Syakir MI, Davoudpour Y, et al. A review on chitosan-cellulose blends and nanocellulose reinforced chitosan biocomposites: Properties and their applications. Carbohydrate polymers. 2016;150.
Wu Y-B, Yu S-H, Mi F-L, Wu C-W, Shyu S-S, Peng C-K, et al. Preparation and characterization on mechanical and antibacterial properties of chitsoan/cellulose blends. Carbohydrate polymers. 2004;57:435-40.
Straccia M, Romano I, Oliva A, Santagata G, Laurienzo P. Cross linker effects on functional properties of alginate/N-succinylchitosan based hydrogels. Carbohydrate polymers. 2014;108:321-30.
Dai M, Zheng X, Xu X, Kong X, Xingyi L, Guo G, et al. Chitosan-Alginate Sponge: Preparation and Application in Curcumin Delivery for Dermal Wound Healing in Rat. Journal of biomedicine & biotechnology. 2009;2009:595126.
Zhao R, Li X, Sun B, Zhang Y, Zhang D, Tang Z, et al. Electrospun chitosan/sericin composite nanofibers with antibacterial property as potential wound dressings. International journal of biological macromolecules. 2014;68:92-7.
Cai Z-X, Mo X-M, Zhang K-H, Fan L-P, Yin A-L, He C-L, et al. Fabrication of chitosan/silk fibroin composite nanofibers for wound-dressing applications. International journal of molecular sciences. 2010;11(9):3529-39.
Bhardwaj N, Kundu SC. Silk fibroin protein and chitosan polyelectrolyte complex porous scaffolds for tissue engineering applications. Carbohydrate polymers. 2011;85(2):325-33.
Sanchez R, Martínez-Arredondo E, Martínez-López V, Melgarejo-Ramírez Y, Molina AM, Lugo H, et al. Development of Hydrogel with Anti-Inflammatory Properties Permissive for the Growth of Human Adipose Mesenchymal Stem Cells. Journal of Nanomaterials. 2016;2016:1-8.
Xiao Y, Reis LA, Feric N, Knee EJ, Gu J, Cao S, et al. Diabetic wound regeneration using peptide-modified hydrogels to target re-epithelialization. Proceedings of the National Academy of Sciences of the United States of America. 2016;113(40):E5792-e801.
Ma L, Gao C, Mao Z, Zhou J, Shen J, Hu X, et al. Collagen/chitosan porous scaffolds with improved biostability for skin tissue. Biomaterials. 2003;24:4833-41.
Madasamy P, Lokhande G, Singh A, Gaharwar A. Engineered Nanomaterials for Infection Control and Healing Acute and Chronic Wounds. ACS Applied Materials & Interfaces. 2016;8.
Laidmäe I, Ērglis K, Cēbers A, Janmey PA, Uibo R. Salmon fibrinogen and chitosan scaffold for tissue engineering: in vitro and in vivo evaluation. J Mater Sci Mater Med. 2018;29(12):182-.
Kweon D-K, Song S-B, Park Y-Y. Preparation of water-soluble chitosan/heparin complex and its application as wound healing accelerator. Biomaterials. 2003;24(9):1595-601.
Galeano M, Polito F, Bitto A, Irrera N, Campo G, Avenoso A, et al. Systemic administration of high-molecular weight hyaluronan stimulates wound healing in genetically diabetic mice. Biochimica et biophysica acta. 2011;1812:752-9.
Uppal R, Ramaswamy G, Arnold C, Goodband R, Wang Y. Hyaluronic acid nanofiber wound dressing--Production, characterization, and in vivo behavior. Journal of biomedical materials research Part B, Applied biomaterials. 2011;97:20-9.
Chang Q, Gao H, Ge L, zhong W, Lu F, Xing M. Injectable aldehyded 1-amino-3, 3-diethoxy-propane hyaluronic acid-chitosan hydrogels as carrier of adipose derived stem cells to enhance angiogenesis and promote skin regeneration. J Mater Chem B. 2015;3.
Blažević F, Milekic T, Duvnjak M, Juretić M, Pepić I, Filipovic-Grcic J, et al. Nanoparticle-mediated interplay of chitosan and melatonin for improved wound epithelialisation. Carbohydrate polymers. 2016;146.
Huang X, Zhang Y, Xu L, Chen X, Wei S. Influence of radiation crosslinked carboxymethyl-chitosan/gelatin hydrogel on cutaneous wound healing. Materials science & engineering C, Materials for biological applications. 2013;33:4816-24.
Lin Y-H, Lin J-H, Li T-S, Wang S-H, Yao C-H, Chung W-Y, et al. Dressing with epigallocatechin gallate-nanoparticles for wound regeneration. Wound Repair and Regeneration. 2015;24:n/a-n/a.
Cai N, Li C, Han C, Luo X, Shen L, Xue Y, et al. Tailoring mechanical and antibacterial properties of chitosan/gelatin nanofiber membranes with Fe3O4 nanoparticles for potential wound dressing application. Applied Surface Science. 2016;369:492-500.
Yousefi I, Pakravan M, Rahimi H, Bahador A, Farshadzadeh Z, Haririan I. An investigation of electrospun Henna leaves extract-loaded chitosan based nanofibrous mats for skin tissue engineering. Materials Science and Engineering: C. 2017;75:433-44.
Mirzaei E, Sarkar S, Rezayat M, Faridi-Majidi R. Herbal Extract Loaded Chitosan-Based Nanofibers as a Potential Wound-Dressing. Journal of Advanced Medical Sciences and Applied Technologies. 2016;2:141.
Jayaram U, Sindhu R, Sakthivel S, Gurusamy A. HERBAL EXTRACT ENCAPSULATED IN CHITOSAN NANOPARTICLE: A NOVEL STRATEGY FOR THE TREATMENT OF UROLITHIASIS2018.
Chandrasekar S, Vijayakumar S, Rajendran R. Application of chitosan and herbal nanocomposites to develop antibacterial medical textile. Biomedicine & Aging Pathology. 2013;4.
Zhao H-R, Wang K, Zhao Y, Pan L-Q. Novel sustained-release implant of herb extract using chitosan. Biomaterials. 2002;23(23):4459-62.
Rasaee I, Ghannadnia M, Honari H. Antibacterial properties of biologically formed chitosan nanoparticles using aqueous leaf extract of Ocimum basilicum. Nanomedicine Journal. 2016;3(4):240-7.
Bai L, Huang T-B. A Novel Wound Dressing Composed of Nonwoven Fabric Coated with Chitosan and Herbal Extract Membrane for Wound Healing. Polymer Composites. 2009;31:1037-46.
Melo M. Chitosan membrane incorporated with Passiflora edulis Sims extract for potential application as wound dressing. Advances in Tissue Engineering & Regenerative Medicine: Open Access. 2019;5.
Shukla R, Kashaw SK, Jain AP, Lodhi S. Fabrication of Apigenin loaded gellan gum-chitosan hydrogels (GGCH-HGs) for effective diabetic wound healing. Int J Biol Macromol. 2016;91:1110-9.
Ferreira MOG, Leite LLR, de Lima IS, Barreto HM, Nunes LCC, Ribeiro AB, et al. Chitosan Hydrogel in combination with Nerolidol for healing wounds. Carbohydrate polymers. 2016;152:409-18.
Annapoorna M, Sudheesh Kumar PT, Lakshman LR, Lakshmanan VK, Nair SV, Jayakumar R. Biochemical properties of Hemigraphis alternata incorporated chitosan hydrogel scaffold. Carbohydrate polymers. 2013;92(2):1561-5.
Emamgholi A, Rahimi M, Kaka G, Sadraie sh, Najafi S. Presentation of a novel model of chitosan- polyethylene oxide-nanohydroxyapatite nanofibers together with bone marrow stromal cells to repair and improve minor bone defects. Iranian journal of basic medical sciences. 2015;18:887-93.
Yuan T, Jenkins P, Foushee A, Jockheck-Clark A, Stahl J. Electrospun Chitosan/Polyethylene Oxide Nanofibrous Scaffolds with Potential Antibacterial Wound Dressing Applications. Journal of Nanomaterials. 2016;2016:1-10.
Abraham A, Soloman PA, Rejini VO. Preparation of Chitosan-Polyvinyl Alcohol Blends and Studies on Thermal and Mechanical Properties. Procedia Technology. 2016;24:741-8.
Kang Y, Yoon I-S, Lee S, Kim D-D, Lee SJ, Park WH, et al. Chitosan-coated poly(vinyl alcohol) nanofibers for wound dressings. Journal of biomedical materials research Part B, Applied biomaterials. 2009;92:568-76.
Abdelgawad AM, Hudson SM, Rojas OJ. Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems. Carbohydrate polymers. 2014;100:166-78.
Gonçalves R, Ferreira W, Gouvêa R, Andrade C. Effect of Chitosan on the Properties of Electrospun Fibers From Mixed Poly(Vinyl Alcohol)/Chitosan Solutions. Materials Research. 2017;20.
Sambudi N, Park S, Cho K. Enhancing the mechanical properties of electrospun chitosan/poly(vinyl alcohol) fibers by mineralization with calcium carbonate. Journal of Materials Science. 2016;51.
Zhou Y, Yang D, Chen X, Xu Q, Lu F, Nie J. Electrospun Water-Soluble Carboxyethyl Chitosan/Poly(vinyl alcohol) Nanofibrous Membrane as Potential Wound Dressing for Skin Regeneration. Biomacromolecules. 2008;9:349-54.
Nacer Khodja A, Mahlous M, Tahtat D, Benamer S, Larbi Youcef S, Chader H, et al. Evaluation of healing activity of PVA/chitosan hydrogels on deep second degree burn: pharmacological and toxicological tests. Burns. 2013;39(1):98-104.
Lahooti B, Khorram M, Karimi G, Mohammadi A, Emami A. Modeling and optimization of antibacterial activity of the chitosan-based hydrogel films using central composite design. Journal of biomedical materials research Part A. 2016;104(10):2544-53.
Amin MA, Abdel-Raheem IT. Accelerated wound healing and anti-inflammatory effects of physically cross linked polyvinyl alcohol-chitosan hydrogel containing honey bee venom in diabetic rats. Archives of pharmacal research. 2014;37(8):1016-31.
Noori S, Kokabi M, Hassan ZM. Nanoclay Enhanced the Mechanical Properties of Poly(Vinyl Alcohol) /Chitosan /Montmorillonite Nanocomposite Hydrogel as Wound Dressing. Procedia Materials Science. 2015;11:152-6.
Zhang X, Yang D, Nie J. Chitosan/polyethylene glycol diacrylate films as potential wound dressing material. International journal of biological macromolecules. 2008;43(5):456-62.
Halabalová V, Šimek L. A Study of the Interaction between Chitosan and Poly(Ethylene Glycol) by Viscosity Method. International Journal of Polymer Analysis and Characterization. 2006;11(3):185-95.
Tanodekaew S, Prasitsilp M, Swasdison S, Thavornyutikarn B, Pothsree T, Pateepasen R. Preparation of acrylic grafted chitin for wound dressing application. Biomaterials. 2004;25:1453-60.
Ahmed S, Ikram S. Silver Nanoparticles: One Pot Green Synthesis Using Terminalia arjuna Extract for Biological Application. Journal of Nanomedicine & Nanotechnology. 2015;6.
Vimala K, Mohan YM, Sivudu KS, Varaprasad K, Ravindra S, Reddy NN, et al. Fabrication of porous chitosan films impregnated with silver nanoparticles: a facile approach for superior antibacterial application. Colloids and surfaces B, Biointerfaces. 2010;76(1):248-58.
Madhumathi K, Sudheesh Kumar PT, Abhilash S, Sreeja V, Tamura H, Manzoor K, et al. Development of novel chitin/nanosilver composite scaffolds for wound dressing applications. J Mater Sci Mater Med. 2010;21(2):807-13.
Chen M, Yang Z, Wu H, Pan X, Xie X, Wu C. Antimicrobial activity and the mechanism of silver nanoparticle thermosensitive gel. International journal of nanomedicine. 2011;6:2873-7.
Rahimi M, Ahmadi R, Kafil H, Shafiei Irannejad V. A novel bioactive quaternized chitosan and its silver-containing nanocomposites as a potent antimicrobial wound dressing: Structural and biological properties. Materials Science and Engineering C. 2019.
Haider A, Haider S, Kang I-K, Kumar A, Kummara MR, Kamal T, et al. A novel use of cellulose based filter paper containing silver nanoparticles for its potential application as wound dressing agent. International Journal of Biological Macromolecules. 2017;108.
Díez-Pascual A, Diez-Vicente A. Wound Healing Bionanocomposites Based on Castor Oil Polymeric Films Reinforced with Chitosan-Modified ZnO Nanoparticles. Biomacromolecules. 2015;16.
Kumar PT, Lakshmanan VK, Anilkumar TV, Ramya C, Reshmi P, Unnikrishnan AG, et al. Flexible and microporous chitosan hydrogel/nano ZnO composite bandages for wound dressing: in vitro and in vivo evaluation. ACS Appl Mater Interfaces. 2012;4(5):2618-29.
Anjum S, Arora A, Alam MS, Gupta B. Development of Antimicrobial and Scar Preventive Chitosan Hydrogel Wound Dressings. International journal of pharmaceutics. 2016;508.
Zhang D, Zhou W, Wei B, Wang X, Tang R, Nie J, et al. Carboxyl-modified poly(vinyl alcohol)-crosslinked chitosan hydrogel films for potential wound dressing. Carbohydrate polymers. 2015;125.
Pulat M, Kahraman A, Tan N, Gümüşderelioğlu M. Sequential antibiotic and growth factor releasing chitosan-PAAm semi-IPN hydrogel as a novel wound dressing. Journal of biomaterials science Polymer edition. 2013;24:807-19.
Ngadaonye J, McEvoy K, Geever L, Brady D, Higginbotham C. Evaluation of Novel Antibiotic-Eluting Thermoresponsive Chitosan-PDEAAm Based Wound Dressings. International Journal of Polymeric Materials and Polymeric Biomaterials. 2014;63:873–83.
El-Naggar M, Gohar Y, Sorour M, Rofeal M. Hydrogel dressing with a nano-formula against methicillin-resistant S. aureus and P. aeruginosa diabetic foot bacteria. Journal of microbiology and biotechnology. 2015;26.
Sinha M, Banik R, Haldar C, Maiti P. Development of ciprofloxacin hydrochloride loaded poly(ethylene glycol)/chitosan scaffold as wound dressing. Journal of Porous Materials. 2013;20.
Profire L, Pieptu D, Dumitriu R, Dragostin O, Vasile C. Sulfadiazine modified CS/HA PEC destined to wound dressing. Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 2013;117:525-31.
Mahmoud A, Salama A. Norfloxacin-loaded collagen/chitosan scaffold for skin reconstruction: Preparation, evaluation and in-vivo wound healing assessment. European Journal of Pharmaceutical Sciences. 2015;83.
Radhakumary C, Antonty M, Sreenivasan K. Drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing. Carbohydrate polymers. 2011;83(2):705-13.
Sun Y, Liu Y, Li Y, Lv M, Li P, Xu H, et al. Preparation and characterization of novel curdlan/chitosan blending membranes for antibacterial applications. Carbohydrate Polymers. 2011;84:952-9.
McIntosh M, Stone BA, Stanisich VA. Curdlan and other bacterial (1→3)-β-D-glucans. Applied microbiology and biotechnology. 2005;68:163-73.
Dvorak H. Vascular permeability to plasma, plasma proteins, and cells: An update. Current opinion in hematology. 2010;17:225-9.
Guo S, DiPietro LA. Factors Affecting Wound Healing. Journal of Dental Research. 2010;89(3):219-29.
Mizuno K, Yamamura K, Yano K, Osada T, Saeki S, Takimoto N, et al. Effect of chitosan film containing basic fibroblast growth factor on wound healing in genetically diabetic mice. Journal of biomedical materials research Part A. 2003;64(1):177-81.
Park C-J, Clark S, Lichtensteiger C, Jamison R, Wagoner Johnson A. Accelerated wound closure of pressure ulcers in aged mice by chitosan scaffolds with and without bFGF. Acta biomaterialia. 2009;5:1926-36.
Alemdaroğlu C, Değim Z, Celebi N, Zor F, Oztürk S, Erdoğan D. An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor. Burns : journal of the International Society for Burn Injuries. 2006;32:319-27.
Obara K, Ishihara M, Fujita M, Kanatani Y, Hattori H, Matsui T, et al. Acceleration of wound healing in healing-impaired db/db mice with a photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2005;13(4):390-7.
Gopal A, Kant V, Gopalakrishnan A, Tandan SK, Kumar D. Chitosan-based copper nanocomposite accelerates healing in excision wound model in rats. European journal of pharmacology. 2014;731:8-19.
Judith R, Nithya M, Rose C, Mandal A. Application of a PDGF-containing novel gel for cutaneous wound healing. Life sciences. 2010;87:1-8.
Frank S, Hübner G, Breier G, Longaker MT, Greenhalgh DG, Werner S. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing. The Journal of biological chemistry. 1995;270(21):12607-13.
- Abstract Viewed: 700 times
- PDF Downloaded: 262 times