Gastroprotective and Anti-Helicobacter Pylori Potentials of Pistacia atlantica Gum Essential Oil Using Experimental Rat Models Pistacia atlantica gum essential oil and peptic ulcer
Iranian Journal of Pharmaceutical Sciences,
Vol. 21 No. 1 (2025),
21 Bahman 2025
,
Page 1-10
https://doi.org/10.22037/ijps.v21i1.46157
Abstract
Gastric ulcers are one of the disorders that have a substantial effect on people's lives, and many treatment options come with side effects. This study was conducted to explore the protective and therapeutic properties of the essential oil of the Pistacia atlantica subspecies kurdica gum on gastric ulcers and gastropathy in rats and its acute oral toxicity and chemical analysis. The animals were administered the essential oil at different doses (12.5, 25, 50, and 100 mg/kg of body weight orally for 21 days) before receiving 85% ethanol. The stomachs were then removed for macroscopic and microscopic examination. Then, we used the Helicobacter pylori-induced rat model of gastropathy. The oral administration of the essential oil at doses of 12.5, 25, 50, and 100 mg/kg of body weight showed strong dose-dependent protection against stomach ulcers caused by ethanol, Additionally, the histological examination shows that the essential oil can prevent ethanol-caused stomach ulcers. Administration of the gum at a dose of 100 mg/kg for 21 days may have antibacterial effects on H. pylori. The findings showed that the essential oil of Pistacia atlantica gum, which contains a high quantity of alpha-pinene (>90%), can be beneficial in treating and preventing peptic ulcers in rat models caused by ethanol and H. pylori.
- Peptic ulcer
- Pistacia atlantica subspecies kurdica
- Ethanol
- H. pylori
How to Cite
References
Al-Juhaishi, A., Gastroprotective activity of alpha-pinene in ethanol-induced gastric mucosal damage in rats. kerbala journal of pharmaceutical sciences, 2014(8).
Magalhães, R., et al., Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species. Pharmacognosy Magazine, 2015. 11(41): p. 123-130.
Tassou, C.C. and G. Nychas, Antimicrobial activity of the essential oil of mastic gum (Pistacia lentiscus var. chia) on Gram positive and Gram negative bacteria in broth and in Model Food System. International biodeterioration & biodegradation, 1995. 36(3-4): p. 411-420.
Salehi, B., et al., Therapeutic potential of α-and β-pinene: A miracle gift of nature. Biomolecules, 2019. 9(11): p. 738.
Naseri, V., F. Kafilzadeh, and H. Jahani-Azizabadi, Effects of Pistacia atlantica gum essential oil on ruminal methanogen, protozoa, selected bacteria species and fermentation characteristics in sheep. Small Ruminant Research, 2022. 209: p. 106650.
Memariani, Z., et al., Protective effect of essential oil of Pistacia atlantica Desf. on peptic ulcer: Role of α-pinene. Journal of Traditional Chinese Medicine, 2017. 37(1): p. 57-63.
Mahjoub, F., et al., Effect of Pistacia atlantica kurdica gum on diabetic gastroparesis symptoms: a randomized, triple-blind placebo-controlled clinical trial. Electronic physician, 2018. 10(7): p. 6997.
Garg, G., S. Nigam, and C. Ogle, The gastric antiulcer effects of the leaves of the neem tree. Planta medica, 1993. 59(03): p. 215-217.
De Pasquale, R., et al., Antiulcer activity of Pteleopsis suberosa. Journal of ethnopharmacology, 1995. 47(1): p. 55-58.
RHL, S., et al., Gastroprotective activity of alpha-terpineol in two experimental models of gastric ulcer in rats. 2011.
Yang HyeJeong, Y.H., et al., Gastroprotective actions of Taraxacum coreanum Nakai water extracts in ethanol-induced rat models of acute and chronic gastritis. 2017.
Wang Gang, W.G., et al., Involvement of aquaporin 3 in Helicobacter pylori-related gastric diseases. 2012.
Ali, D.E., et al., Gastroprotective and anti-Helicobacter pylori potentials of essential oils from the oleoresins of Araucaria bidwillii and Araucaria heterophylla. Inflammopharmacology, 2023. 31(1): p. 465-483.
Kim, S.-e., et al., Gastroprotective effect of phytoncide extract from Pinus koraiensis pinecone in Helicobacter pylori infection. Scientific reports, 2020. 10(1): p. 9547.
do Carmo Souza, M., et al., In vitro and in vivo anti-Helicobacter pylori activity of Calophyllum brasiliense Camb. Journal of Ethnopharmacology, 2009. 123(3): p. 452-458.
Siriviriyakul, P., et al., Genistein attenuated gastric inflammation and apoptosis in Helicobacter pylori-induced gastropathy in rats. BMC gastroenterology, 2020. 20: p. 1-9.
Simões, S., et al., Animal models of acute gastric mucosal injury: Macroscopic and microscopic evaluation. Animal models and experimental medicine, 2019. 2(2): p. 121-126.
Chinedu, E., D. Arome, and F.S. Ameh, A new method for determining acute toxicity in animal models. Toxicology international, 2013. 20(3): p. 224.
Ahmed, Z.B., et al., Four Pistacia atlantica subspecies (atlantica, cabulica, kurdica and mutica): A review of their botany, ethnobotany, phytochemistry and pharmacology. Journal of Ethnopharmacology, 2021. 265: p. 113329.
Rauf, A., et al., In vitro leishmanicidal potential and silico study of flavonoids isolated from Pistacia integerrima Stew ex Brandis. Journal of King Saud University-Science, 2023. 35(3): p. 102572.
Hatamnia, A.A., N. Abbaspour, and R. Darvishzadeh, Antioxidant activity and phenolic profile of different parts of Bene (Pistacia atlantica subsp. kurdica) fruits. Food chemistry, 2014. 145: p. 306-311.
Erhirhie, E.O., C.P. Ihekwereme, and E.E. Ilodigwe, Advances in acute toxicity testing: strengths, weaknesses and regulatory acceptance. Interdisciplinary toxicology, 2018. 11(1): p. 5-12.
Hasheminya, S.-M. and J. Dehghannya, Composition, phenolic content, antioxidant and antimicrobial activity of Pistacia atlantica subsp. kurdica hulls’ essential oil. Food Bioscience, 2020. 34: p. 100510.
Nachvak, S.M., et al., Chemical composition and antioxidant activity of Pistacia atlantica subsp. Kurdica from Awraman. Journal of Reports in Pharmaceutical Sciences, 2018. 7(3): p. 222-230.
Fathollahi, M., et al. Antioxidant capacity, antimicrobial activities and chemical composition of Pistacia atlantica subsp. kurdica essential oil. in Veterinary Research Forum. 2019. Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Azeez, S.H. and S.M. Gaphor, Evaluation of antibacterial effect against Porphyromonas gingivalis and biocompatibility of essential oil extracted from the gum of Pistacia atlantica kurdica. BioMed research international, 2019. 2019(1): p. 9195361.
Khodavaisy, S., et al., Effects of Pistacia atlantica subsp. kurdica on Growth and Aflatoxin Production by Aspergillus parasiticus. Jundishapur journal of microbiology, 2016. 9(7).
Afrasiabian, H., et al., The effect of oral administration of pistacia atlantica kurdica gum on the eradication of helicobacter pylori in patients with dyspepsia: A randomized clinical trial. Global Journal of Health Science, 2016. 9(2): p. 256.
Meriem, M., et al., Antimicrobial activity of the essential oil isolated from Pistacia lentiscus leaves against Helicobacter pylori algerian clinical isolates. Journal of Essential Oil Bearing Plants, 2016. 19(2): p. 466-474.
Gurbuz, I., et al., Characterization of volatiles and anti-ulcerogenic effect of Turkish sweetgum balsam (Styrax liquidus). Journal of ethnopharmacology, 2013. 148(1): p. 332-336.
Alipour, G., S. Dashti, and H. Hosseinzadeh, Review of pharmacological effects of Myrtus communis L. and its active constituents. Phytotherapy research, 2014. 28(8): p. 1125-1136.
- Abstract Viewed: 95 times
- IJPS_Volume21_Issue1_Pages1-10 Downloaded: 66 times