Investigating the Analgesic Effects of the Chenopodium Botrys L. Hydroalcoholic Extract Using Behavioral Tests on Mice
Iranian Journal of Pharmaceutical Sciences,
Vol. 19 No. 3 (2023),
1 July 2023
,
Page 208- 216
https://doi.org/10.22037/ijps.v19i3.43433
Abstract
Regarding the unpleasant pain sensation and the public’s desire to use traditional herbs, the present study aimed to assess the analgesic and anti-inflammatory effect of Chenopodium botrys L. The present research was divided into two main sections to assess the analgesic and anti-inflammatory effect of Chenopodium botrys L. in male mice. To investigate the analgesic effect of Chenopodium botrys L., thirty-six male mice were randomly classified into six groups vehicle (receiving normal saline), experimental groups received morphine (a well-known opioid, 1 mg/kg), hydroalcoholic extracts of Chenopodium botrys L. (30, 100, and 300 mg/kg), and naloxone (opioid receptor antagonist) with the highest dose of Chenopodium botrys L. concurrently for one week. Thirty mice were divided into five groups to receive normal saline, various doses of extract (30, 100, and 300 mg/kg), and dexamethasone (a well-known anti-inflammatory drug, 10 mg/kg) to assess the anti-inflammatory effect of Chenopodium botrys L. In both sections, after the last doses of the treatment, the animals got ready for behavioral study related to pain. Overall, the highest doses of Chenopodium botrys L. demonstrated much better results than other doses, which were comparable to opioids and dexamethasone, a well-known analgesic and anti-inflammatory medicines, respectively. Regarding present findings, the Chenopodium botrys L. plant can be a new candidate as an analgesic agent, which needs more investigation in the search and pharmaceutical development.
- Chenopodium botrys
- analgesia
- pain
- mice
- opioid
How to Cite
References
Świeboda P, Filip R, Prystupa A, Drozd M. Assessment of pain: types, mechanism and treatment. Pain (2013) 2(7).
Belmonte C. Pain, dryness, and itch sensations in eye surface disorders are defined by a balance between inflammation and sensory nerve injury. Cornea (2019) 38:S11-S24.
Linton SJ. A transdiagnostic approach to pain and emotion. Journal of Applied Biobehavioral Research (2013) 18(2):82-103.
Shraim MA, Masse-Alarie H, Hall LM, Hodges PW. Systematic review and synthesis of mechanism-based classification systems for pain experienced in the musculoskeletal system. The Clinical journal of pain (2020) 36(10):793-812.
Zielińska A, Włodarczyk M, Makaro A, Sałaga M, Fichna J. Management of pain in colorectal cancer patients. Critical Reviews in Oncology/Hematology (2021) 157:103122.
Shimo K, Ogawa S, Niwa Y, Tokiwa Y, Dokita A, Kato S, et al. Inhibition of current perception thresholds in A-delta and C fibers through somatosensory stimulation of the body surface. Scientific Reports (2022) 12(1):1-6.
Talagas M, Lebonvallet N, Berthod F, Misery L. Cutaneous nociception: role of keratinocytes. Experimental Dermatology (2019) 28(12):1466-9.
D’Amato T, Martorelli F, Fenocchio G, Simili V, Kon E, Di Matteo B, et al. Tapentadol vs oxycodone/naloxone in the management of pain after total hip arthroplasty in the fast track setting: an observational study. Journal of Experimental Orthopaedics (2019) 6(1):1-7.
Korbut R, Guzik TJ. Inflammatory Mediators and Intracellular Signalling. Nijkamp and Parnham's Principles of Immunopharmacology (2019):139-63.
Wang RX, Zhou M, Ma HL, Qiao YB, Li QS. The Role of Chronic Inflammation in Various Diseases and Anti‐inflammatory Therapies Containing Natural Products. ChemMedChem (2021) 16(10):1576-92.
Fatima Shad K, Soubra W, Cordato DJ. The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases. Clinical and Experimental Pharmacology and Physiology (2021) 48(11):1445-53.
Trento MMS, Moré AOO, Duarte ECW, Martins DF. Peripheral receptors and neuromediators involved in the antihyperalgesic effects of acupuncture: a state-of-the-art review. Pflügers Archiv-European Journal of Physiology (2021) 473(4):573-93.
Khan A, Khan S, Kim YS. Insight into pain modulation: nociceptors sensitization and therapeutic targets. Current drug targets (2019) 20(7):775-88.
Mohammadkhani A, Borgland SL. Cellular and behavioral basis of cannabinioid and opioid interactions: implications for opioid dependence and withdrawal. Journal of Neuroscience Research (2022) 100(1):278-96.
Kaczmarski P, Karuga FF, Szmyd B, Sochal M, Białasiewicz P, Strzelecki D, et al. The role of inflammation, hypoxia, and opioid receptor expression in pain modulation in patients suffering from obstructive sleep apnea. International Journal of Molecular Sciences (2022) 23(16):9080.
Gazelka HM, Leal JC, Lapid MI, Rummans TA, editors. Opioids in older adults: indications, prescribing, complications, and alternative therapies for primary care. Mayo Clinic Proceedings; 2020: Elsevier.
Han Y, Yan W, Zheng Y, Khan MZ, Yuan K, Lu L. The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies. Translational psychiatry (2019) 9(1):282.
James PB, Kaikai AI, Bah AJ, Steel A, Wardle J. Herbal medicine use during breastfeeding: a cross-sectional study among mothers visiting public health facilities in the Western area of Sierra Leone. BMC complementary and alternative medicine (2019) 19(1):1-11.
Dehghan M, Namjoo Z, Bahrami A, Tajedini H, Shamsaddini-Lori Z, Zarei A, et al. The use of complementary and alternative medicines, and quality of life in patients under hemodialysis: A survey in southeast Iran. Complementary Therapies in Medicine (2020) 51:102431.
Nasim S, Shah M, Shah SWA, Ahmed MN, Ahmad M, Anwar N, et al. Activity guided isolation and mechanistic approach towards analgesic potential of Chenopodium mediated through opioidergic pathway. Pakistan Journal of Pharmaceutical Sciences (2021) 34.
SEZER ENŞ, UYSAL T. Phenolic screening and biological activities of Chenopodium botrys L. extracts. Anatolian Journal of Botany (2021) 5(2):78-83.
Fallahzadeh AR, Mohammadi S. Assessment of the antinociceptive, anti-inflammatory, and acute toxicity effects of solanum dulcamara essential oil in male mice. Journal of Babol University of Medical Sciences (2020) 22(1):162-8.
de Cássia da Silveira e Sá R, Andrade LN, de Sousa DP. A review on anti-inflammatory activity of monoterpenes. Molecules (2013) 18(1):1227-54.
Verri Jr WA, Vicentini FTMC, Baracat MM, Georgetti SR, Cardoso RDR, Cunha TM, et al. Flavonoids as anti-inflammatory and analgesic drugs: mechanisms of action and perspectives in the development of pharmaceutical forms. Studies in natural products chemistry (2012) 36:297-330.
Ferraz CR, Carvalho TT, Manchope MF, Artero NA, Rasquel-Oliveira FS, Fattori V, et al. Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development. Molecules (2020) 25(3):762.
- Abstract Viewed: 228 times
- IJPS_Volume19_Issue3_Pages 208-216 Downloaded: 129 times