Determination of Sulfasalazine in Sulfasalazine Tablets Using Silver Nanoparticles Sulfasalazine using silver nanoparticles
Iranian Journal of Pharmaceutical Sciences,
Vol. 8 No. 2 (2012),
1 April 2012
,
Page 129-134
https://doi.org/10.22037/ijps.v8.40960
Abstract
Resonance light scattering (RLS) intensity of silver nanoparticles in the presence of sodium dodecylsulphate was quenched on addition of sulfasalzine. The quenching extent was shown to be proportional to the sulfasalazine concentration. Effect of different parameters such as pH, volume and kind of buffer, silver nanoparticles concentration, sodium dodecylsulphate (SDS) concentration, and waiting time on
RLS quenching were investigated. Calibration curve was linear in the range of 10 to 70 μg ml-1. Detection limit was determined as 0.012 mg.ml-1. The method was successfully applied to the determination of sulfasalazine in different batch numbers of sulfasalazine tablets. The results were compared with those determined by USP method. Reasonable agreements were observed.
- Resonance light scattering
- Silver nanoparticles
- Sulfasalazine
How to Cite
References
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