Anti-inflammatory Activity of Essential Oil of Canarium Strictum Roxb Anti-inflammatory activity of essential oil of Canarium strictum Roxb
Iranian Journal of Pharmaceutical Sciences,
Vol. 9 No. 2 (2013),
1 April 2013
,
Page 13-21
https://doi.org/10.22037/ijps.v9.40891
Abstract
Canarium L., used in folk medicine as anti-inflammatory, antibacterial, antifungal, antitumor and heptoprotective and antioxidant and anti diabetic. The present study investigated the in vivo anti-inflammatory activity of essential oil obtained by hydro distillation of Black dammer resin of Canarium strictum Roxb. Anti-inflammatory activity of essential oil of Canarium strictum Roxb., EOCS (10-100 mg/kg) has been established by using the carrageenan (acute inflammation model) and formalin (chronic inflammation model) induced paw edema in mice. The dose dependent activity has been observed at the higher dose of EOCS 100 mg /kg (P<0.0001). EOCS exhibited momentous anti-inflammatory activity that was compared with standard drug diclofenac sodium in acute inflammatory animal models. The perceived anti-inflammatory activity might be due to inhibition of histamine, serotonin, kinins, substance P and prostaglandins, and bradykinin at the inflamed area. On the other hand, in the formalin test EOCS 100 mg /kg reduced chronic inflammation most effectively (P<0.0001). Our data supported that EOCS capable to inhibit the paw edema in acute and chronic inflammation in the experimental animal models can be evident to use this oil for the treatment of chronic and acute inflammatory disorders. More elaborate investigation is needed in this aspect and to correlate the possible effect of major terpene which it produced anti-inflammatory activity.
- Black dammer
- Burseraceae
- Canarium strictum
- Essential oil
- Inflammation
- Oleoresin
How to Cite
References
[2] Augustine J, Krishnan PG: Status of the black dammar tree (Canarium strictum Roxb) in Periyar Tiger Reserve, Kerala and the uses of black dammar, Indian Forester (2006), 132(10):1329–1335.
[3] Calder PC. N-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am. J. Clin. Nutr (2006) 83 (6): 1505-1519.
[4] Chau TT. Analgesic testing in animal models. In:pharmacological methods in the control of inflammations. Alan R Liss lnc: New York (1989) 448-452.
[5] Chopra RN, Nayer SL, Chopra IC: Glossary of Indian Medicinal Plants: Council of Scientific and Industrial Research: New Delhi (1956).
[6] Corrado B, Marco T, Colucci R, Fornai M, Antonioli L, Ghisu N, Tacca MD. Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal antiinflammatory therapy. Pharm Res (2009) 59: 90-100.
[7] Damiao Pergentino de sousa: Review analgesic like activity of essential oil constituents. Molecules (2011)16: 2233-2252.
[8] Desha Meena, Nagarajan Binaibabu, Jesubalan Doss: Future prospects for the critically endangered medicinally important species, Canarium strictum Roxb. A Review Int J Conser Sci. ( 2012) 3: 231-237.
[9] Ecobichon DJ: The Basis of Toxicology Testing. CRC press, New York, 1997: 43-86.
[10] Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003; 423, 356-361.
[11] Greenwald, R.A. Animal models for evaluation of arthritic drugs. Meth. Find. Clin. Pharmacol. (1991) 13(2): 75-83.
[12] Heapy CG, Jamieson A, Russel NJW. Afferent C-fiber and A- delta fiber activity in models of inflammation. (1987) Br J Pharmacol 90:164-170.
[13] Hinge VK, Wagh SK, Bhattacharyya SC: Constituents of Indian black dammer resin, Tetrahedron. (1965) 21: 3597-3203.
[14] Hinge VK, Paknikar SK, Das KG, Bose AK, Bhattacharyya SC: Terpenoids -LXXXVI: Structure of epi -ψ- taraxastanonol and epi -ψ-taraxastanediol, Tetrahedron. (1966) 22: 2861- 2868.
[15] Indian institute of forest management: Report of the conservation assessment and management plan workshop for non timber forest products of Nilgiri biosphere reserve., 2001.
[16] Miller LC, Tainter ML: Behavioral toxicity studies. Proceedings of the society for experimental biology and medicine. 1994 3: 544-547.
[17] Mogana R, Wiart C: Canarium L., A Phytochemical and Pharmacological Review. Journal of Pharmacy Research (2011) 8: 2482-2489.
[18] Molur S, Walker S: Report on Conservation Assessment and Management Plan Workshop for selected species of the medicinal plants of southern India, Bangalore, 1997, 72-73.
[19] Murray CW, Porreca F, Cowan A: Methodological refinements to the mouse paw formalin test. J Pharmacol Toxicol Methods (1988) 20:175-186.
[20] Nadkarni KM: Indian Materia Medica, Popular Prakashan : Bombay (1989).
[21] Suruse PB, Duragkar NJ, Shivhare UD, Kale MK, Bodele SB: Study of antibacterial activity of Canarium strictum gum resin.Research journal of Pharmacognosy and Phytochemistry, 2010 2: 435-437.
[22] Suruse PB, Duragkar NJ, Bodele SB, Kale MK: Evaluation of pharma cological activities of isolated triterpenoids from Canarium strictum. International journal of universal pharmacy and life sciences. 2011 3:110-119.Anti-inflammatory activity of essential oil of Canarium strictum Roxb
[23] Suruse PB,Bodele SB, Duragkar NJ, Kale MK : Anti-inflammatory and analgesic activities of isolated triterpenoids from Canarium strictum gum resin. Journal of cell and tissue research (2008) 8: 1481-1484.
[24] Vijayastelter Liju B, Kottarapat jeena, Ramadasan Kuttan: An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa.L. Indian journal of pharmacology (2011) 43: 526-531.
[25] Wallis RS, Broder MS, Wong JY, Hanson ME, Beenhouwer DO. Granulomatous infectious diseases associated with tumor necrosis factor antagonists. Clin Infect Dis (2004) 38 (9): 1261-1265.
[26] Winters CA, Risley EA, Nuss GW: Carrageenin induced edema in hind-paw of the rat as an assay for inflammatory drugs. Proceedings of the Soc Exptl Biol Med (1962)111: 544-547.
- Abstract Viewed: 222 times
- IJPS_Volume 9_Issue 2_Pages 13-21 Downloaded: 75 times