The Association of Breastfeeding and Multiple Sclerosis: Does Formula have any other Risks?
Archives of Advances in Biosciences,
Vol. 15 No. 1 (2024),
24 January 2024
,
Page 1-7
https://doi.org/10.22037/aab.v15i1.43096
Abstract
Introduction: Multiple sclerosis (MS) is a complex autoimmune disorder of the central nervous system that affects millions of individuals worldwide. While the etiology of MS remains multifactorial and incompletely understood, emerging evidence suggests that various environmental and lifestyle factors may influence its onset and progression. Among these factors, breastfeeding has gained attention as a potential protective mechanism against the development of MS. However, it is unclear whether breastfeeding, colostrum feeding, and formula or cow milk intake during infancy have any relationship with the development of MS, which type of MS would be influenced further, and if breastfeeding has any effect on the age of MS onset.
Materials and Methods: 100 MS patients and 100 healthy controls took part in this study. Male to female ratio was similar in both groups. Demographic characteristics and history of breastfeeding were collected via a questionnaire.
Results: The mean duration of breastfeeding was considerably lower in some MS patients who had onset of the disease before or at the age of 30 compared to those with onset after 30 years (15.2 + 10.2 versus 19.5 + 11.0 months, P = 0.09). Breastfeeding with a duration of more than 11 months was more frequent in the latter group (83% versus 60%, P = 0.044). Patients with age-onset before or at 30 also revealed a higher rate of feeding with formula or cow milk (56.5% versus 33% and P = 0.063). More frequent feeding with formula or cow milk among MS patients compared to healthy controls (51% versus 31%, P=0.006) was observed.
Conclusion: Formula or cow milk consumption during infancy may be a considerable risk factor for developing MS besides other etiologic factors.
- Breast-feeding
- Colostrum
- Formula feeding
- Multiple sclerosis
How to Cite
References
Ascherio A, Munger KL. Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention-An Update. Semin Neurol. 2016;36(2):103-14. [DOI: 10.1055/s-0036-1579693] [PMID]
Heydarpour P, Khoshkish S, Abtahi S, Moradi-Lakeh M, Sahraian MA. Multiple Sclerosis Epidemiology in Middle East and North Africa: A Systematic Review and Meta-Analysis. Neuroepidemiology. 2015;44(4):232-44. [DOI: 10.1159/000431042] [PMID]
Makhani N, Morrow SA, Fisk J, Evans C, Beland SG, Kulaga S, Kingwell E, Marriott JJ, Dykeman J, Jetté N, Pringsheim T, Wolfson C, Marrie RA, Koch MW. MS incidence and prevalence in Africa, Asia, Australia and New Zealand: A systematic review. Mult Scler Relat Disord. 2014;3(1):48-60. [DOI: 10.1016/j.msard.2013.06.015] [PMID]
Koch-Henriksen N, Sørensen PS. The changing demographic pattern of multiple sclerosis epidemiology. Lancet Neurol. 2010;9(5):520-32. [DOI: 10.1016/S1474-4422(10)70064-8] [PMID]
5. Bashinskaya VV, Kulakova OG, Boyko AN, Favorov AV, Favorova OO. A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches. Hum Genet. 2015;134(11-12):1143-62. [DOI: 10.1007/s00439-015-1601-2] [PMID]
Nicol B, Salou M, Laplaud DA, Wekerle H. The autoimmune concept of multiple sclerosis.
Presse Med. 2015;44(4 Pt 2):e103-12. [DOI: 10.1016/j.lpm.2015.02.009] [PMID]
De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, et al The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009;106(13):5264-9. [DOI: 10.1073/pnas.0813310106] [PMID] [PMCID]
Patsopoulos NA; Bayer Pharma MS Genetics Working Group; Steering Committees of Studies Evaluating IFNβ-1b and a CCR1-Antagonist; ANZgene Consortium; GeneMSA, et al, Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol. 2011;70(6):897-912. [DOI: 10.1002/ana.22609] [PMID] [PMCID]
Sintzel MB, Rametta M, Reder AT. Vitamin D and Multiple Sclerosis: A Comprehensive Review. Neurol Ther. 2018;7(1):59-85. [DOI: 10.1007/s40120-017-0086-4] [PMID] [PMCID]
Handel AE, Williamson AJ, Disanto G, Dobson R, Giovannoni G, Ramagopalan SV. Smoking and multiple sclerosis: an updated meta-analysis. PLoS One. 2011;6(1):e16149. [DOI: 10.1371/journal.pone.0016149] [PMID] [PMCID]
Pierrot-Deseilligny C, Souberbielle JC. Vitamin D and multiple sclerosis: An update. Mult Scler Relat Disord. 2017;14:35-45. [DOI: 10.1016/j.msard.2017.03.014] [PMID]
Ascherio A, Munger KL. Epstein-barr virus infection and multiple sclerosis: a review. J Neuroimmune Pharmacol. 2010;5(3):271-7. [DOI: 10.1007/s11481-010-9201-3] [PMID]
Horta BL, de Lima NP. Breastfeeding and Type 2 Diabetes: Systematic Review and Meta-Analysis. Curr Diab Rep. 2019;19(1):1. [DOI: 10.1007/s11892-019-1121-x] [PMID]
Altobelli E, Angeletti PM, Verrotti A, Petrocelli R. The Impact of Human Milk on Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis. Nutrients. 2020;12(5):1322. [DOI: 10.3390/nu12051322] [PMID] [PMCID]
Su Q, Sun X, Zhu L, Yan Q, Zheng P, Mao Y, Ye D. Breastfeeding and the risk of childhood cancer: a systematic review and dose-response meta-analysis. BMC Med. 2021;19(1):90. [DOI: 10.1186/s12916-021-01950-5] [PMID] [PMCID]
Alves JG, Figueiroa JN, Meneses J, Alves GV. Breastfeeding protects against type 1 diabetes mellitus: a case-sibling study. Breastfeed Med. 2012;7(1):25-8. [DOI: 10.1089/bfm.2011.0009] [PMID]
McCrory C, Murray A. The effect of breastfeeding on neuro-development in infancy. Matern Child Health J. 2013;17(9):1680-8. [DOI: 10.1007/s10995-012-1182-9] [PMID]
Wheeler TT, Hodgkinson AJ, Prosser CG, Davis SR. Immune components of colostrum and milk--a historical perspective. J Mammary Gland Biol Neoplasia. 2007;12(4):237-47. [DOI: 10.1007/s10911-007-9051-7] [PMID]
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17(2):162-173. [DOI: 10.1016/S1474-4422(17)30470-2] [PMID]
Goulden R, Ibrahim T, Wolfson C. Is high socioeconomic status a risk factor for multiple sclerosis? A systematic review. Eur J Neurol. 2015;22(6):899-911. [DOI: 10.1111/ene.12586] [PMID]
Nielsen NM, Jørgensen KT, Bager P, Stenager E, Pedersen BV, Hjalgrim H, Koch-Henriksen N, Frisch M. Socioeconomic factors in childhood and the risk of multiple sclerosis. Am J Epidemiol. 2013;177(11):1289-95. [DOI: 10.1093/aje/kws350] [PMID]
Conradi S, Malzahn U, Paul F, Quill S, Harms L, Then Bergh F, Ditzenbach A, Georgi T, Heuschmann P, Rosche B. Breastfeeding is associated with lower risk for multiple sclerosis. Mult Scler. 2013;19(5):553-8. [DOI: 10.1177/1352458512459683] [PMID]
Bagur MJ, Murcia MA, Jiménez-Monreal AM, Tur JA, Bibiloni MM, Alonso GL, Martínez-Tomé M. Influence of Diet in Multiple Sclerosis: A Systematic Review. Adv Nutr. 2017;8(3):463-72. [DOI: 10.3945/an.116.014191] [PMID] [PMCID]
Ragnedda G, Leoni S, Parpinel M, Casetta I, Riise T, Myhr KM, Wolfson C, Pugliatti M. Reduced duration of breastfeeding is associated with a higher risk of multiple sclerosis in both Italian and Norwegian adult males: the EnvIMS study. J Neurol. 2015;262(5):1271-7. [DOI: 10.1007/s00415-015-7704-9] [PMID]
Ghaemi-Ahmadi S. Attitudes toward breast-feeding and infant feeding among Iranian, Afghan, and Southeast Asian immigrant women in the United States: implications for health and nutrition education. J Am Diet Assoc. 1992;92(3):354-5. [PMID]
Ahmadi M, Moosavi SM. Evaluation of occupational factors on continuation of breastfeeding and formula initiation in employed mothers. Glob J Health Sci. 2013;5(6):166-71. [DOI: 10.5539/gjhs.v5n6p166] [PMID] [PMCID]
Tarrats R, Ordoñez G, Rios C, Sotelo J. Varicella, ephemeral breastfeeding and eczema as risk factors for multiple sclerosis in Mexicans. Acta Neurol Scand. 2002;105(2):88-94. [DOI: 10.1034/j.1600-0404.2002.1o077.x] [PMID]
Riccio P, Rossano R. Nutrition facts in multiple sclerosis. ASN Neuro. 2015 ;7(1):1759091414568185. [DOI: 10.1177/1759091414568185] [PMID] [PMCID]
Haug A, Høstmark AT, Harstad OM. Bovine milk in human nutrition--a review. Lipids Health Dis. 2007;6:25. [DOI: 10.1186/1476-511X-6-25] [PMID] [PMCID]
Haug A, Høstmark AT, Harstad OM. Bovine milk in human nutrition--a review. Lipids Health Dis. 2007;6:25. [DOI: 10.1186/1476-511X-6-25] [PMID] [PMCID]
Ziegler EE. Growth of breast-fed and formula-fed infants. Protein and energy requirements in infancy and childhood. 2006;58:51-64. [DOI: 10.1159/000195010]
Flom JD, Sicherer SH. Epidemiology of Cow's Milk Allergy. Nutrients. 2019 May 10;11(5):1051. [DOI: 10.3390/nu11051051] [PMID] [PMCID]
Manouchehrinia A, Tanasescu R, Kareem H, Jerca OP, Jabeen F, Shafei R, Breuer J, Neal K, Irving W, Constantinescu CS. Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis. J Neurovirol. 2017;23(6):839-44. [DOI: 10.1007/s13365-017-0569-1] [PMID] [PMCID]
Ladomenou F, Moschandreas J, Kafatos A, Tselentis Y, Galanakis E. Protective effect of exclusive breastfeeding against infections during infancy: a prospective study. Arch Dis Child. 2010;95(12):1004-8. [DOI: 10.1136/adc.2009.169912] [PMID]
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