The Effect of Harmane on Hyperalgesia Induced by Stressed Male Mice in the Presence and Absence of Moderated Exercise
Archives of Advances in Biosciences,
Vol. 10 No. 4 (2019),
14 October 2019
,
Page 15-21
https://doi.org/10.22037/aab.v10i4.27164
Abstract
Introduction: Physical exercise has positive effects on stress-induced pain response, while chronic stress persuades a negative effect on cognitive functions. Depending on the nature, duration and intensity of the stressor, it can repress pain (stress-induced analgesia) or exacerbate pain (stress-induced hyperalgesia). Furthermore, beneficial effects of Harmane on stress processes have been reported in rodents. This study aimed to investigate the effects of Harmane and moderate physical activity (associated or not) on pain response in restraint stressed mice.
Materials and Methods: Harmane was injected intraperitoneally at doses of 0.1, 0.3 and 0.6 mg/kg, every other day until 28 days, and pain response of the adult NMRI mice was detected using the hot-plate test
Results: The results exhibited that Harmane, at all doses used, did not alter pain perception in mice; however, 3- but not 6 and 9-day restraint stress (3 hours per day) induced hyperalgesia per se. In addition, Harmane reduced hyperalgesia in 3-day stressed mice, while moderate treadmill running (10 m/min for 30 min/day, 5 day/week) caused hyperalgesia in 6- and 9-day stressed mice. Furthermore, the hyperalgesia induced by moderate treadmill running in 9-day stressed mice restored by Harmane.
Conclusion: The findings indicated that Harmane has a protective effect on hyperalgesia induced by stress per se or potentiated effect of moderate treadmill running in stressed mice.
- Harmane
- Restraint stress
- Treadmill running
- Pain
- Mice
How to Cite
References
Rommelspacher H, May T, Salewski B, Harman (1-methyl-beta-carboline) is a natural inhibitor of monoamine oxidase type A in rats. European journal of pharmacology. 1994; 252(1): 51-9.
Tilbrook AJ, Turner AI, Clarke IJ, Effects of stress on reproduction in non-rodent mammals: the role of glucocorticoids and sex differences. Reviews of reproduction. 2000; 5(2): 105-13.
Ward KS, Managing stress: an essential of leadership. SCI nursing. 2002; 19(2): 80-1.
Sheline YI, 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity. Biological psychiatry. 2000; 48(8): 791-800.
Parikh D, Hamid A, Friedman TC, Nguyen K, Tseng A, Marquez P, et al., Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration. European journal of pharmacology. 2011; 650(2-3): 563-7.
Amit Z, Galina ZH, Stress-induced analgesia: adaptive pain suppression. Physiological reviews. 1986; 66(4): 1091-120.
Ford GK, Finn DP, Clinical correlates of stress-induced analgesia: evidence from pharmacological studies. Pain. 2008; 140(1): 3-7.
Yilmaz P, Diers M, Diener S, Rance M, Wessa M, Flor H, Brain correlates of stress-induced analgesia. Pain. 2010; 151(2): 522-9.
Dai S, Ma Z, BDNF-trkB-KCC2-GABA pathway may be related to chronic stress-induced hyperalgesia at both the spinal and supraspinal level. Medical hypotheses. 2014; 83(6): 772-4.
Geva N, Defrin R, Enhanced pain modulation among triathletes: a possible explanation for their exceptional capabilities. Pain. 2013; 154(11): 2317-23.
Sherwood A, Smith PJ, Hinderliter AL, Georgiades A, Blumenthal JA, Effects of exercise and stress management training on nighttime blood pressure dipping in patients with coronary heart disease: A randomized, controlled trial. American heart journal. 2017; 183: 85-90.
Donohue B, Covassin T, Lancer K, Dickens Y, Miller A, Hash A, et al., Examination of psychiatric symptoms in student athletes. The Journal of general psychology. 2004; 131(1): 29-35.
Moore MJ, Werch C, Relationship between vigorous exercise frequency and substance use among first-year drinking college students. Journal of American college health. 2008; 56(6): 686-90.
Rommelspacher H, Meier-Henco M, Smolka M, Kloft C, The levels of norharman are high enough after smoking to affect monoamineoxidase B in platelets. Eur J Pharmacol. 2002; 441(1-2): 115-25.
Wronska AK, Bogus MI, Harman and norharman, metabolites of the entomopathogenic fungus Conidiobolus coronatus (Entomophthorales), affect the serotonin levels and phagocytic activity of hemocytes, insect immunocompetent cells, in Galleria mellonella (Lepidoptera). Cell Biosci. 2019; 9: 29.
Zheng W, Wang S, Barnes LF, Guan Y, Louis ED, Determination of harmane and harmine in human blood using reversed-phased high-performance liquid chromatography and fluorescence detection. Anal Biochem. 2000; 279(2): 125-9.
Taylor SC, Little HJ, Nutt DJ, Sellars N, A benzodiazepine agonist and contragonist have hypothermic effects in rodents. Neuropharmacology. 1985; 24(1): 69-73.
Callaway JC, Brito GS, Neves ES, Phytochemical analyses of Banisteriopsis caapi and Psychotria viridis. Journal of psychoactive drugs. 2005; 37(2): 145-50.
Kim DH, Jang YY, Han ES, Lee CS, Protective effect of harmaline and harmalol against dopamine- and 6-hydroxydopamine-induced oxidative damage of brain mitochondria and synaptosomes, and viability loss of PC12 cells. The European journal of neuroscience. 2001; 13(10): 1861-72.
Park TH, Kwon OS, Park SY, Han ES, Lee CS, N-methylated beta-carbolines protect PC12 cells from cytotoxic effect of MPP+ by attenuation of mitochondrial membrane permeability change. Neuroscience research. 2003; 46(3): 349-58.
Head GA, Mayorov DN, Imidazoline receptors, novel agents and therapeutic potential. Cardiovasc Hematol Agents Med Chem. 2006; 4(1): 17-32.
Rovati LC, Brambilla N, Blicharski T, Connell J, Vitalini C, Bonazzi A, et al., Efficacy and safety of the first-in-class imidazoline-2 receptor ligand CR4056 in pain from knee osteoarthritis and disease phenotypes: a randomized, double-blind, placebo-controlled phase 2 trial. Osteoarthritis Cartilage. 2019.
Nasehi M, Shahini F, Ebrahimi-Ghiri M, Azarbayjani M, Zarrindast MR, Effects of harmane during treadmill exercise on spatial memory of restraint-stressed mice. Physiology and behavior. 2018; 194: 239-45.
Javad-Moosavi BZ, Vaezi G, Nasehi M, Haeri-Rouhani SA, Zarrindast MR, Critical role of CA1 muscarinic receptors on memory acquisition deficit induced by total (TSD) and REM sleep deprivation (RSD). Prog Neuropsychopharmacol Biol Psychiatry. 2017; 79(Pt B): 128-35.
Eydipour Z, Vaezi G, Nasehi M, Haeri-Rouhani SA, Zarrindast MR, Different Role of CA1 5HT3 Serotonin Receptors on Memory Acquisition Deficit Induced by Total (TSD) and REM Sleep Deprivation (RSD). Arch Iran Med. 2017; 20(9): 581-88.
Nasehi M, Ghadimi F, Khakpai F, Zarrindast MR, Interaction between harmane, a class of beta-carboline alkaloids, and the CA1 serotonergic system in modulation of memory acquisition. Neuroscience research. 2017; 122: 17-24.
Ashkinazi I, Vershinina EA, Pain sensitivity in chronic psychoemotional stress in humans. Neuroscience and behavioral physiology. 1999; 29(3): 333-7.
Bardin L, Malfetes N, Newman-Tancredi A, Depoortere R, Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies. Behavioural brain research. 2009; 205(2): 360-6.
Marcinkiewcz CA, Green MK, Devine DP, Duarte P, Vierck CJ, Yezierski RP, Social defeat stress potentiates thermal sensitivity in operant models of pain processing. Brain research. 2009; 1251: 112-20.
Imbe H, Kimura A, Donishi T, Kaneoke Y, Repeated forced swim stress enhances CFA-evoked thermal hyperalgesia and affects the expressions of pCREB and c-Fos in the insular cortex. Neuroscience. 2014; 259: 1-11.
Spezia Adachi LN, Caumo W, Laste G, Fernandes Medeiros L, Ripoll Rozisky J, de Souza A, et al., Reversal of chronic stress-induced pain by transcranial direct current stimulation (tDCS) in an animal model. Brain Research. 2012; 1489: 17-26.
Norman GJ, Karelina K, Zhang N, Walton JC, Morris JS, Devries AC, Stress and IL-1beta contribute to the development of depressive-like behavior following peripheral nerve injury. Molecular psychiatry. 2010; 15(4): 404-14.
Sarkar J, Wakefield S, MacKenzie G, Moss SJ, Maguire J, Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. The Journal of neuroscience. 2011; 31(50): 18198-210.
Abu Ghazaleh H, Lalies MD, Nutt DJ, Hudson AL, The modulatory action of harmane on serotonergic neurotransmission in rat brain. Brain Res. 2015; 1597: 57-64.
Yanagita S, Amemiya S, Suzuki S, Kita I, Effects of spontaneous and forced running on activation of hypothalamic corticotropin-releasing hormone neurons in rats. Life sciences. 2007; 80(4): 356-63.
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