Review of the Effects of Vitamin C on Wound Healing
Journal of Otorhinolaryngology and Facial Plastic Surgery,
Vol. 10 No. 1 (2024),
13 March 2024
,
Page 1-5
https://doi.org/10.22037/orlfps.v10i1.47017
Abstract
Background: The healing process is one of the main issues for the medical and general population. Studies have shown that vitamin C can accelerate this process, in this study, we aimed to review the effects of vitamin C on wound healing.
Methods: We searched PubMed, MEDLINE, and Elsevier databases for studies with the keywords “vitamin C” OR “ascorbic acid” AND “wound healing” OR “wound repair.” Studies from the start of 2013 to the end of 2023 were reviewed.
Results: Few studies have evaluated the effects of Vitamin C on wound healing. Six studies were assessed, which found that vitamin C significantly improves wound healing, closure, post-healing appearance, decreased bacterial load, and inflammatory markers.
Conclusion: Given that only a few studies have confirmed the effects of Vitamin C on wound healing, further studies are required to appropriately confirm the association.
- Ascorbic Acid; Vitamin C; Wound; Wound healing.
How to Cite
References
Gupta S, Andersen C, Black J, de Leon J, Fife C, JC LI, et al. Management of Chronic Wounds: Diagnosis, Preparation, Treatment, and Follow-up. Wounds: a compendium of clinical research and practice. 2017;29(9):S19-S36.
Morton LM, Phillips TJ. Wound healing and treating wounds: Differential diagnosis and evaluation of chronic wounds. Journal of the American Academy of Dermatology. 2016;74(4):589-605.
Bryant R, Nix D. Acute and chronic wounds: current management concepts: Elsevier Health Sciences; 2015.
Moores J. Vitamin C: a wound healing perspective. British journal of community nursing. 2013;18(Sup12):S6-S11.
Fisher BJ, Seropian IM, Kraskauskas D, Thakkar JN, Voelkel NF, Natarajan R. Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury. Critical care medicine. 2011;39(6):1454-60.
Mohammed BM, Fisher BJ, Kraskauskas D, Farkas D, Brophy DF, Fowler III AA, et al. Vitamin C: a novel regulator of neutrophil extracellular trap formation. Nutrients. 2013;5(8):3131-50.
Mohammed BM, Fisher BJ, Huynh QK, Wijesinghe DS, Chalfant CE, Brophy DF, et al. Resolution of sterile inflammation: role for vitamin C. Mediators of inflammation. 2014;2014(1):173403.
Fisher BJ, Kraskauskas D, Martin EJ, Farkas D, Puri P, Massey HD, et al. Attenuation of sepsis‐induced organ injury in mice by vitamin C. Journal of Parenteral and Enteral Nutrition. 2014;38(7):825-39.
Chokesuwattanaskul S, Sukpat S, Duangpatra J, Buppajarntham S, Decharatanachart P, Mutirangura A, et al. High dose oral vitamin C and mesenchymal stem cells aid wound healing in a diabetic mouse model. Journal of Wound Care. 2018;27(5):334-9.
Yun IS, Yoo H-S, Kim YO, Rah DK. Improved scar appearance with combined use of silicone gel and vitamin C for Asian patients: A comparative case series. Aesthetic plastic surgery. 2013;37:1176-81.
Shojania HR, Momeni-Moghaddam M, Hossini S-e, Armin M, Omrani Bidi J. MicroRNA 155 Downregulation by Vitamin C–Loaded Human Serum Albumin Nanoparticles During Cutaneous Wound Healing in Mice. The international journal of lower extremity wounds. 2019;18(2):143-52.
Voss GT, Gularte MS, Vogt AG, Giongo JL, Vaucher RA, Echenique JV, et al. Polysaccharide-based film loaded with vitamin C and propolis: A promising device to accelerate diabetic wound healing. International journal of pharmaceutics. 2018;552(1-2):340-51.
Gunton JE, Girgis CM, Lau T, Vicaretti M, Begg L, Flood V. Vitamin C improves healing of foot ulcers: A randomised, double-blind, placebo-controlled trial. British Journal of Nutrition. 2021;126(10):1451-8.
Yarahmadi A, Saeed Modaghegh M-H, Mostafavi-Pour Z, Azarpira N, Mousavian A, Bonakdaran S, et al. The effect of platelet-rich plasma-fibrin glue dressing in combination with oral vitamin E and C for treatment of non-healing diabetic foot ulcers: a randomized, double-blind, parallel-group, clinical trial. Expert Opinion on Biological Therapy. 2021;21(5):687-96.
Hemilä H. Vitamin C and infections. Nutrients. 2017;9(4):339.
Carr AC, McCall C. The role of vitamin C in the treatment of pain: new insights. Journal of translational medicine. 2017;15(1):77.
Magiorkinis E, Beloukas A, Diamantis A. Scurvy: past, present and future. European journal of internal medicine. 2011;22(2):147-52.
Dresen E, Lee ZY, Hill A, Notz Q, Patel JJ, Stoppe C. History of scurvy and use of vitamin C in critical illness: A narrative review. Nutrition in Clinical Practice. 2023;38(1):46-54.
Hambidge KM. Micronutrient bioavailability: Dietary Reference Intakes and a future perspective. The American journal of clinical nutrition. 2010;91(5):1430S-2S.
Schleicher RL, Carroll MD, Ford ES, Lacher DA. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES). The American journal of clinical nutrition. 2009;90(5):1252-63.
Carr AC, Lykkesfeldt J. Factors affecting the vitamin C dose-concentration relationship: Implications for global vitamin C dietary recommendations. Nutrients. 2023;15(7):1657.
Carr AC, Rowe S. Factors affecting vitamin C status and prevalence of deficiency: A global health perspective. Nutrients. 2020;12(7):1963.
Marcos A. A review of micronutrients and the immune system—Working in harmony to reduce the risk of infection. MDPI; 2021. p. 4180.
Percival SS. Nutrition and immunity: balancing diet and immune function. Nutrition Today. 2011;46(1):12-7.
Oz HS. Nutrients, infectious and inflammatory diseases. MDPI; 2017. p. 1085.
Jiang Q. Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy. Free Radical Biology and Medicine. 2014;72:76-90.
Nazrun A, Norazlina M, Norliza M, Nirwana SI. The anti‐inflammatory role of vitamin e in prevention of osteoporosis. Advances in Pharmacological and Pharmaceutical Sciences. 2012;2012(1):142702.
Wallert M, Börmel L, Lorkowski S. Inflammatory diseases and vitamin E—what do we know and where do we go? Molecular Nutrition & Food Research. 2021;65(1):2000097.
- Abstract Viewed: 118 times
- PDF Downloaded: 101 times